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Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila
Leesa LaFever and
Daniela Drummond-Barbosa*
Stem cells reside in specialized niches that provide signalsrequired for their maintenance and division. Tissue-extrinsicsignals can also modify stem cell activity, although this ispoorly understood. Here, we report that neural-derived Drosophilainsulin-like peptides (DILPs) directly regulate germline stemcell division rate, demonstrating that signals mediating theovarian response to nutritional input can modify stem cell activityin a niche-independent manner. We also reveal a crucial directrole of DILPs in controlling germline cyst growth and vitellogenesis.
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232–8240, USA.
* To whom correspondence should be addressed. E-mail: daniela.drummond-barbosa{at}vanderbilt.edu
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