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Originally published in Science Express on 7 July 2005
Science 5 August 2005:
Vol. 309. no. 5736, pp. 897 - 903
DOI: 10.1126/science.1116269
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Research Articles

Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel

Stephen B. Long, Ernest B. Campbell, Roderick MacKinnon*

Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase ß subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and ß subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the ß subunit.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

* To whom correspondence should be addressed. E-mail: mackinn{at}rockefeller.edu

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   Abstract »    Full Text »    PDF »
Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel.
E. Sadovsky and O. Yifrach (2007)
PNAS 104, 19813-19818
   Abstract »    Full Text »    PDF »
The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels.
J. Eldstrom, Z. Wang, H. Xu, M. Pourrier, A. Ezrin, K. Gibson, and D. Fedida (2007)
Mol. Pharmacol. 72, 1522-1534
   Abstract »    Full Text »    PDF »
Role of the S6 C-terminus in KCNQ1 channel gating.
I. R. Boulet, A. J. Labro, A. L. Raes, and D. J. Snyders (2007)
J. Physiol. 585, 325-337
   Abstract »    Full Text »    PDF »
Topology of the selectivity filter of a TRPV channel: rapid accessibility of contiguous residues from the external medium.
Y. Dodier, F. Dionne, A. Raybaud, R. Sauve, and L. Parent (2007)
Am J Physiol Cell Physiol 293, C1962-C1970
   Abstract »    Full Text »    PDF »
Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.
H. Yang, L. Hu, J. Shi, K. Delaloye, F. T. Horrigan, and J. Cui (2007)
PNAS 104, 18270-18275
   Abstract »    Full Text »    PDF »


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