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Science 29 July 2005:
Vol. 309. no. 5735, pp. 764 - 767
DOI: 10.1126/science.1112699
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Reports

Pesticide Resistance via Transposition-Mediated Adaptive Gene Truncation in Drosophila

Yael T. Aminetzach, J. Michael Macpherson, Dmitri A. Petrov*

To study adaptation, it is essential to identify multiple adaptive mutations and to characterize their molecular, phenotypic, selective, and ecological consequences. Here we describe a genomic screen for adaptive insertions of transposable elements in Drosophila. Using a pilot application of this screen, we have identified an adaptive transposable element insertion, which truncates a gene and apparently generates a functional protein in the process. The insertion of this transposable element confers increased resistance to an organophosphate pesticide and has spread in D. melanogaster recently.

Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA.

* To whom correspondence should be addressed. E-mail: dpetrov{at}stanford.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonadaptive Explanations for Signatures of Partial Selective Sweeps in Drosophila.
J. M. Macpherson, J. Gonzalez, D. M. Witten, J. C. Davis, N. A. Rosenberg, A. E. Hirsh, and D. A. Petrov (2008)
Mol. Biol. Evol. 25, 1025-1042
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Selection on Major Components of Angiosperm Genomes.
B. S. Gaut and J. Ross-Ibarra (2008)
Science 320, 484-486
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Rapid R2 Retrotransposition Leads to the Loss of Previously Inserted Copies via Large Deletions of the rDNA Locus.
X. Zhang, J. Zhou, and T. H. Eickbush (2008)
Mol. Biol. Evol. 25, 229-237
   Abstract »    Full Text »    PDF »
Genomewide Spatial Correspondence Between Nonsynonymous Divergence and Neutral Polymorphism Reveals Extensive Adaptation in Drosophila.
J. M. Macpherson, G. Sella, J. C. Davis, and D. A. Petrov (2007)
Genetics 177, 2083-2099
   Abstract »    Full Text »    PDF »
Origins of New Male Germ-line Functions from X-Derived Autosomal Retrogenes in the Mouse.
M.-S. Shiao, P. Khil, R. D. Camerini-Otero, T. Shiroishi, K. Moriwaki, H.-T. Yu, and M. Long (2007)
Mol. Biol. Evol. 24, 2242-2253
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Cis-Regulatory Elements in the Accord Retrotransposon Result in Tissue-Specific Expression of the Drosophila melanogaster Insecticide Resistance Gene Cyp6g1.
H. Chung, M. R. Bogwitz, C. McCart, A. Andrianopoulos, R. H. ffrench-Constant, P. Batterham, and P. J. Daborn (2007)
Genetics 175, 1071-1077
   Abstract »    Full Text »    PDF »
How reliable are empirical genomic scans for selective sweeps?.
K. M. Teshima, G. Coop, and M. Przeworski (2006)
Genome Res. 16, 702-712
   Abstract »    Full Text »    PDF »
Remarkable Site Specificity of Local Transposition Into the Hsp70 Promoter of Drosophila melanogaster.
V. Y. Shilova, D. G. Garbuz, E. N. Myasyankina, B. Chen, M. B. Evgen'ev, M. E. Feder, and O. G. Zatsepina (2006)
Genetics 173, 809-820
   Abstract »    Full Text »    PDF »
Overexpression of the 14{alpha}-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii.
Z. Ma, T. J. Proffer, J. L. Jacobs, and G. W. Sundin (2006)
Appl. Envir. Microbiol. 72, 2581-2585
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)