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Science 29 July 2005:
Vol. 309. no. 5735, pp. 764 - 767
DOI: 10.1126/science.1112699
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Reports

Pesticide Resistance via Transposition-Mediated Adaptive Gene Truncation in Drosophila

Yael T. Aminetzach, J. Michael Macpherson, Dmitri A. Petrov*

To study adaptation, it is essential to identify multiple adaptive mutations and to characterize their molecular, phenotypic, selective, and ecological consequences. Here we describe a genomic screen for adaptive insertions of transposable elements in Drosophila. Using a pilot application of this screen, we have identified an adaptive transposable element insertion, which truncates a gene and apparently generates a functional protein in the process. The insertion of this transposable element confers increased resistance to an organophosphate pesticide and has spread in D. melanogaster recently.

Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA.

* To whom correspondence should be addressed. E-mail: dpetrov{at}stanford.edu

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