Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
IBC-DDT

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Originally published in Science Express on 2 June 2005
Science 8 July 2005:
Vol. 309. no. 5732, pp. 264 - 268
DOI: 10.1126/science.1110267
Prev | Table of Contents | Next

Research Articles

Professional Antigen-Presentation Function by Human {gamma}{delta} T Cells

Marlène Brandes, Katharina Willimann, Bernhard Moser*

Human {gamma}{delta} T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the V{gamma}2V{delta}2+–T cell receptor (V{delta}2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve {alpha}ß T cell proliferation and differentiation. We suggest that, upon microbial activation, V{delta}2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.

Institute of Cell Biology, University of Bern, CH-3012, Switzerland.

* To whom correspondence should be addressed. E-mail: bernhard.moser{at}izb.unibe.ch

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The probiotic Escherichia coli strain Nissle 1917 induces {gamma}{delta} T cell apoptosis via caspase- and FasL-dependent pathways.
C. Guzy, D. Paclik, A. Schirbel, U. Sonnenborn, B. Wiedenmann, and A. Sturm (2008)
Int. Immunol. 20, 829-840
   Abstract »    Full Text »    PDF »
CD4+CD25+ Treg cells inhibit human memory {gamma}{delta} T cells to produce IFN-{gamma} in response to M tuberculosis antigen ESAT-6.
L. Li and C.-Y. Wu (2008)
Blood 111, 5629-5636
   Abstract »    Full Text »    PDF »
Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via V{gamma}9{gamma}{delta} T cell activation.
M. Takahara, M. Miyai, M. Tomiyama, M. Mutou, A. J. Nicol, and M. Nieda (2008)
J. Leukoc. Biol. 83, 742-754
   Abstract »    Full Text »    PDF »
Activation of cytotoxic T-cell receptor {gamma}{delta} T lymphocytes in response to specific stimulation in myelodysplastic syndromes.
J.-J. Kiladjian, G. Visentin, E. Viey, S. Chevret, V. Eclache, J. Stirnemann, J. H. Bourhis, S. Chouaib, P. Fenaux, and A. Caignard (2008)
Haematologica 93, 381-389
   Abstract »    Full Text »    PDF »
Autoimmunity Stimulated by Adoptively Transferred Dendritic Cells Is Initiated by Both {alpha}beta and {gamma}{delta} T Cells but Does Not Require MyD88 Signaling.
D. A. Martin, K. Zhang, J. Kenkel, G. Hughes, E. Clark, A. Davidson, and K. B. Elkon (2007)
J. Immunol. 179, 5819-5828
   Abstract »    Full Text »    PDF »
Role of {alpha}/beta and {gamma}/{delta} T cells in renal ischemia-reperfusion injury.
K. Hochegger, T. Schatz, P. Eller, A. Tagwerker, D. Heininger, G. Mayer, and A. R. Rosenkranz (2007)
Am J Physiol Renal Physiol 293, F741-F747
   Abstract »    Full Text »    PDF »
Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid.
F. Fiore, B. Castella, B. Nuschak, R. Bertieri, S. Mariani, B. Bruno, F. Pantaleoni, M. Foglietta, M. Boccadoro, and M. Massaia (2007)
Blood 110, 921-927
   Abstract »    Full Text »    PDF »
The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia.
R. Chakraverty and M. Sykes (2007)
Blood 110, 9-17
   Abstract »    Full Text »    PDF »
The Graft Content of Donor T Cells Expressing {gamma}{delta}TCR+ and CD4+foxp3+ Predicts the Risk of Acute Graft versus Host Disease after Transplantation of Allogeneic Peripheral Blood Stem Cells from Unrelated Donors.
C. Pabst, H. Schirutschke, G. Ehninger, M. Bornhauser, and U. Platzbecker (2007)
Clin. Cancer Res. 13, 2916-2922
   Abstract »    Full Text »    PDF »
Human CD4+ T Cells Displaying Viral Epitopes Elicit a Functional Virus-Specific Memory CD8+ T Cell Response.
E. Adamopoulou, J. Diekmann, E. Tolosa, G. Kuntz, H. Einsele, H.-G. Rammensee, and M. S. Topp (2007)
J. Immunol. 178, 5465-5472
   Abstract »    Full Text »    PDF »
Massive, sustained {gamma}{delta} T cell migration from the bovine skin in vivo.
I. Van Rhijn, V. P. M. G. Rutten, B. Charleston, M. Smits, W. van Eden, and A. P. Koets (2007)
J. Leukoc. Biol. 81, 968-973
   Abstract »    Full Text »    PDF »
Distinct Cytokine-Driven Responses of Activated Blood {gamma}{delta} T Cells: Insights into Unconventional T Cell Pleiotropy.
D. Vermijlen, P. Ellis, C. Langford, A. Klein, R. Engel, K. Willimann, H. Jomaa, A. C. Hayday, and M. Eberl (2007)
J. Immunol. 178, 4304-4314
   Abstract »    Full Text »    PDF »
{gamma}{delta} T Cells Promote Anterior Chamber-Associated Immune Deviation and Immune Privilege through Their Production of IL-10.
H. M. Ashour and J. Y. Niederkorn (2006)
J. Immunol. 177, 8331-8337
   Abstract »    Full Text »    PDF »
CXCR5 Identifies a Subset of V{gamma}9V{delta}2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production.
N. Caccamo, L. Battistini, M. Bonneville, F. Poccia, J. J. Fournie, S. Meraviglia, G. Borsellino, R. A. Kroczek, C. La Mendola, E. Scotet, et al. (2006)
J. Immunol. 177, 5290-5295
   Abstract »    Full Text »    PDF »
Comparative gene expression by WC1+ {gamma}{delta} and CD4+ {alpha}{beta} T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ {gamma}{delta} T cells..
K. K. Lahmers, J. F. Hedges, M. A. Jutila, M. Deng, M. S. Abrahamsen, and W. C. Brown (2006)
J. Leukoc. Biol. 80, 939-952
   Abstract »    Full Text »    PDF »
IL-17 Production Is Dominated by {gamma}{delta} T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection.
E. Lockhart, A. M. Green, and J. L. Flynn (2006)
J. Immunol. 177, 4662-4669
   Abstract »    Full Text »    PDF »
CD8+ Cytotoxic T-APC Stimulate Central Memory CD8+ T Cell Responses via Acquired Peptide-MHC Class I Complexes and CD80 Costimulation, and IL-2 Secretion..
D. Xia, S. Hao, and J. Xiang (2006)
J. Immunol. 177, 2976-2984
   Abstract »    Full Text »    PDF »
{gamma}{delta} T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice.
T. Wang, Y. Gao, E. Scully, C. T. Davis, J. F. Anderson, T. Welte, M. Ledizet, R. Koski, J. A. Madri, A. Barrett, et al. (2006)
J. Immunol. 177, 1825-1832
   Abstract »    Full Text »    PDF »
A ticket to the gut for thymic T cells.
W Falk (2006)
Gut 55, 910-912
   Full Text »    PDF »
Topical Application of Escherichia coli-Vectored Vaccine as a Simple Method for Eliciting Protective Immunity..
J. Zhang, Z. Shi, F.-k. Kong, E. Jex, Z. Huang, J. M. Watt, K. R. Van Kampen, and D.-c. C. Tang (2006)
Infect. Immun. 74, 3607-3617
   Abstract »    Full Text »    PDF »
TCR{gamma}{delta} Intraepithelial Lymphocytes Are Required for Self-Tolerance..
N. R. Locke, S. Stankovic, D. P. Funda, and L. C. Harrison (2006)
J. Immunol. 176, 6553-6559
   Abstract »    Full Text »    PDF »
Sex-specific phenotypical and functional differences in peripheral human V{gamma}9/V{delta}2 T cells.
N. Caccamo, F. Dieli, D. Wesch, H. Jomaa, and M. Eberl (2006)
J. Leukoc. Biol. 79, 663-666
   Abstract »    Full Text »    PDF »
Homing and Function of Human Skin {gamma}{delta} T Cells and NK Cells: Relevance for Tumor Surveillance.
L. M. Ebert, S. Meuter, and B. Moser (2006)
J. Immunol. 176, 4331-4336
   Abstract »    Full Text »    PDF »
Direct Costimulatory Effect of TLR3 Ligand Poly(I:C) on Human {gamma}{delta} T Lymphocytes.
D. Wesch, S. Beetz, H.-H. Oberg, M. Marget, K. Krengel, and D. Kabelitz (2006)
J. Immunol. 176, 1348-1354
   Abstract »    Full Text »    PDF »
Potentiation of Antigen-Stimulated V{gamma}9V{delta}2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation.
M.-C. Devilder, S. Maillet, I. Bouyge-Moreau, E. Donnadieu, M. Bonneville, and E. Scotet (2006)
J. Immunol. 176, 1386-1393
   Abstract »    Full Text »    PDF »
Regulation of Acquired Immunity by {gamma}{delta} T-Cell/Dendritic-Cell Interactions.
N. SHRESTHA, J. A. IDA, A. S. LUBINSKI, M. PALLIN, G. KAPLAN, and P. A.J. HASLETT (2005)
Ann. N.Y. Acad. Sci. 1062, 79-94
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)