Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Policy Alerts

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 June 2005:
Vol. 308. no. 5730, pp. 1923 - 1927
DOI: 10.1126/science.1112103
Prev | Table of Contents | Next

Reports

Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling

Kwan L. Ng, Jia-Da Li, Michelle Y. Cheng, Frances M. Leslie, Alex G. Lee, Qun-Yong Zhou*

Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricular zone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within the OB, PK2 may also act as a detachment signal for chain-migrating progenitors arriving from the RMS. PK2 deficiency in mice leads to a marked reduction in OB size, loss of normal OB architecture, and the accumulation of neuronal progenitors in the RMS. These findings define an essential role for G protein–coupled PK2 signaling in postnatal and adult OB neurogenesis.

Department of Pharmacology, University of California–Irvine (UCI), Irvine, CA 92697, USA.

* To whom correspondence should be addressed. E-mail: qzhou{at}uci.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Homozygous mutation in the prokineticin-receptor2 gene (Val274Asp) presenting as reversible Kallmann syndrome and persistent oligozoospermia: Case Report.
A. A. Sinisi, R. Asci, G. Bellastella, L. Maione, D. Esposito, A. Elefante, A. De Bellis, A. Bellastella, and A. Iolascon (2008)
Hum. Reprod.
   Abstract »    Full Text »    PDF »
Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling.
D. Garzotto, P. Giacobini, T. Crepaldi, A. Fasolo, and S. De Marchis (2008)
J. Neurosci. 28, 5901-5909
   Abstract »    Full Text »    PDF »
Loss of prokineticin receptor 2 signaling predisposes mice to torpor.
P. H. Jethwa, H. I'Anson, A. Warner, H. M. Prosser, M. H. Hastings, E. S. Maywood, and F. J. P. Ebling (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R1968-R1979
   Abstract »    Full Text »    PDF »
Prokineticin Receptor-1 Induces Neovascularization and Epicardial-Derived Progenitor Cell Differentiation.
K. Urayama, C. Guilini, G. Turkeri, S. Takir, H. Kurose, N. Messaddeq, A. Dierich, and C. G. Nebigil (2008)
Arterioscler. Thromb. Vasc. Biol. 28, 841-849
   Abstract »    Full Text »    PDF »
Mitogenic functions of endocrine gland-derived vascular endothelial growth factor and Bombina variegata 8 on steroidogenic adrenocortical cells.
M. Keramidas, C. Faudot, A. Cibiel, J.-J. Feige, and M. Thomas (2008)
J. Endocrinol. 196, 473-482
   Abstract »    Full Text »    PDF »
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression.
F. Shojaei, M. Singh, J. D. Thompson, and N. Ferrara (2008)
PNAS 105, 2640-2645
   Abstract »    Full Text »    PDF »
Cyclin-Dependent Kinase 5 Is Required for Control of Neuroblast Migration in the Postnatal Subventricular Zone.
Y. Hirota, T. Ohshima, N. Kaneko, M. Ikeda, T. Iwasato, A. B. Kulkarni, K. Mikoshiba, H. Okano, and K. Sawamoto (2007)
J. Neurosci. 27, 12829-12838
   Abstract »    Full Text »    PDF »
From the Cover: Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
N. Pitteloud, C. Zhang, D. Pignatelli, J.-D. Li, T. Raivio, L. W. Cole, L. Plummer, E. E. Jacobson-Dickman, P. L. Mellon, Q.-Y. Zhou, et al. (2007)
PNAS 104, 17447-17452
   Abstract »    Full Text »    PDF »
The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.
K. Urayama, C. Guilini, N. Messaddeq, K. Hu, M. Steenman, H. Kurose, G. Ert, and C. G. Nebigil (2007)
FASEB J 21, 2980-2993
   Abstract »    Full Text »    PDF »
Blood Vessels Form a Scaffold for Neuroblast Migration in the Adult Olfactory Bulb.
S. Bovetti, Y.-C. Hsieh, P. Bovolin, I. Perroteau, T. Kazunori, and A. C. Puche (2007)
J. Neurosci. 27, 5976-5980
   Abstract »    Full Text »    PDF »
Dlx-Dependent and -Independent Regulation of Olfactory Bulb Interneuron Differentiation.
J. E. Long, S. Garel, M. Alvarez-Dolado, K. Yoshikawa, N. Osumi, A. Alvarez-Buylla, and J. L. R. Rubenstein (2007)
J. Neurosci. 27, 3230-3243
   Abstract »    Full Text »    PDF »
Prokineticin 2 Is a Target Gene of Proneural Basic Helix-Loop-Helix Factors for Olfactory Bulb Neurogenesis.
C. Zhang, K. L. Ng, J.-D. Li, F. He, D. J. Anderson, Y. E. Sun, and Q.-Y. Zhou (2007)
J. Biol. Chem. 282, 6917-6921
   Abstract »    Full Text »    PDF »
{beta}1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream.
R. Belvindrah, S. Hankel, J. Walker, B. L. Patton, and U. Muller (2007)
J. Neurosci. 27, 2704-2717
   Abstract »    Full Text »    PDF »
Implications of Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 Signaling in Human Neuroblastoma Progression.
E. S.W. Ngan, F. Y.L. Sit, K. L. Lee, X. Miao, Z. Yuan, W. Wang, J. M. Nicholls, K. K.Y. Wong, M. Garcia-Barcelo, V. C.H. Lui, et al. (2007)
Clin. Cancer Res. 13, 868-875
   Abstract »    Full Text »    PDF »
Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.
H. M. Prosser, A. Bradley, J. E. Chesham, F. J. P. Ebling, M. H. Hastings, and E. S. Maywood (2007)
PNAS 104, 648-653
   Abstract »    Full Text »    PDF »
The Prokineticins: A NOVEL PAIR OF REGULATORY PEPTIDES.
Q.-Y. Zhou (2006)
Mol. Interv. 6, 330-338
   Abstract »    Full Text »    PDF »
Attenuated Circadian Rhythms in Mice Lacking the Prokineticin 2 Gene..
J.-D. Li, W.-P. Hu, L. Boehmer, M. Y. Cheng, A. G. Lee, A. Jilek, J. M. Siegel, and Q.-Y. Zhou (2006)
J. Neurosci. 26, 11615-11623
   Abstract »    Full Text »    PDF »
Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2..
S.-i. Matsumoto, C. Yamazaki, K.-h. Masumoto, M. Nagano, M. Naito, T. Soga, H. Hiyama, M. Matsumoto, J. Takasaki, M. Kamohara, et al. (2006)
PNAS 103, 4140-4145
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)