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Science 3 June 2005:
Vol. 308. no. 5727, pp. 1463 - 1465
DOI: 10.1126/science.1108661
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Reports

Accelerated Intestinal Epithelial Cell Turnover: A New Mechanism of Parasite Expulsion

Laura J. Cliffe,1 Neil E Humphreys,1 Thomas E. Lane,2 Chris S. Potten,3 Cath Booth,3 Richard K. Grencis1*

The functional integrity of the intestinal epithelial barrier forms a major defense against invading pathogens, including gastrointestinal-dwelling nematodes, which are ubiquitous in their distribution worldwide. Here, we show that an increase in the rate of epithelial cell turnover in the large intestine acts like an "epithelial escalator" to expel Trichuris and that the rate of epithelial cell movement is under immune control by the cytokine interleukin-13 and the chemokine CXCL10. This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense.

1 Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
2 Department of Molecular Biology and Biochemistry, University of California Irvine, 3205 McGaugh Hall, Irvine, CA 92697, USA.
3 Epistem Limited, Incubator Building, Grafton Street, Manchester, M13 9XX, UK.

* To whom correspondence should be addressed. E-mail: Richard.K.Grencis{at}manchester.ac.uk

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