Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 20 May 2005:
Vol. 308. no. 5725, pp. 1181 - 1184
DOI: 10.1126/science.1109083

Reports

Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

Marieke A. G. Essers,1 Lydia M. M. de Vries-Smits,1 Nick Barker,2 Paulien E. Polderman,1 Boudewijn M. T. Burgering,1* Hendrik C. Korswagen2*

ß-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of the T cell factor (TCF) family of transcription factors. Here, we report an evolutionarily conserved interaction of ß-catenin with FOXO transcription factors, which are regulated by insulin and oxidative stress signaling. ß-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells. In Caenorhabditis elegans, loss of the ß-catenin BAR-1 reduces the activity of the FOXO ortholog DAF-16 in dauer formation and life span. Association of ß-catenin with FOXO was enhanced in cells exposed to oxidative stress. Furthermore, BAR-1 was required for the oxidative stress–induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage. These results demonstrate a role for ß-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress.

1 Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands.
2 Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

* To whom correspondence should be addressed. E-mail: b.m.t.burgering{at}med.uu.nl and rkors{at}niob.knaw.nl

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Terminal Region of {beta}-Catenin Promotes Stability by Shielding the Armadillo Repeats from the Axin-scaffold Destruction Complex.
R. Mo, T.-L. Chew, M. T. Maher, G. Bellipanni, E. S. Weinberg, and C. J. Gottardi (2009)
J. Biol. Chem. 284, 28222-28231
   Abstract »    Full Text »    PDF »
POU Homeodomain Protein Oct-1 Functions as a Sensor for Cyclic AMP.
P. Wang, Q. Wang, J. Sun, J. Wu, H. Li, N. Zhang, Y. Huang, B. Su, R.-k. Li, L. Liu, et al. (2009)
J. Biol. Chem. 284, 26456-26465
   Abstract »    Full Text »    PDF »
Progesterone Inhibition of Wnt/{beta}-Catenin Signaling in Normal Endometrium and Endometrial Cancer.
Y. Wang, P. Hanifi-Moghaddam, E. E. Hanekamp, H. J. Kloosterboer, P. Franken, J. Veldscholte, H. C. van Doorn, P. C. Ewing, J. J. Kim, J. A. Grootegoed, et al. (2009)
Clin. Cancer Res. 15, 5784-5793
   Abstract »    Full Text »    PDF »
Wnt Signaling from Development to Disease: Insights from Model Systems.
K. M. Cadigan and M. Peifer (2009)
Cold Spring Harb Perspect Biol 1, a002881
   Abstract »    Full Text »    PDF »
Maternal obesity downregulates myogenesis and {beta}-catenin signaling in fetal skeletal muscle.
J. F. Tong, X. Yan, M. J. Zhu, S. P. Ford, P. W. Nathanielsz, and M. Du (2009)
Am J Physiol Endocrinol Metab 296, E917-E924
   Abstract »    Full Text »    PDF »
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation.
Y. Mei, Y. Zhang, K. Yamamoto, W. Xie, T. W. Mak, and H. You (2009)
PNAS 106, 5153-5158
   Abstract »    Full Text »    PDF »
FOXO3a: a novel player in thyroid carcinogenesis?.
S. Karger, C. Weidinger, K. Krause, S.-Y. Sheu, T. Aigner, O. Gimm, K.-W. Schmid, H. Dralle, and D. Fuhrer (2009)
Endocr. Relat. Cancer 16, 189-199
   Abstract »    Full Text »    PDF »
A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer.
J.-Y. Yang and M.-C. Hung (2009)
Clin. Cancer Res. 15, 752-757
   Abstract »    Full Text »    PDF »
Forkhead box-O transcription factor: critical conductors of cancer's fate.
C. Weidinger, K. Krause, A. Klagge, S. Karger, and D. Fuhrer (2008)
Endocr. Relat. Cancer 15, 917-929
   Abstract »    Full Text »    PDF »
Role for {beta}-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
J. E. Irazoqui, A. Ng, R. J. Xavier, and F. M. Ausubel (2008)
PNAS 105, 17469-17474
   Abstract »    Full Text »    PDF »
The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression.
R. C.-Y. Hui, A. R. Gomes, D. Constantinidou, J. R. Costa, C. T. Karadedou, S. Fernandez de Mattos, M. P. Wymann, J. J. Brosens, A. Schulze, and E. W.-F. Lam (2008)
Mol. Cell. Biol. 28, 5886-5898
   Abstract »    Full Text »    PDF »
N-Glycans in cancer progression.
K. S Lau and J. W Dennis (2008)
Glycobiology 18, 750-760
   Abstract »    Full Text »    PDF »
FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells.
S. Fernandez de Mattos, P. Villalonga, J. Clardy, and E. W-F. Lam (2008)
Mol. Cancer Ther. 7, 3237-3246
   Abstract »    Full Text »    PDF »
Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the {beta}-Catenin-TCF4 Complex.
L.-N. Song and E. P. Gelmann (2008)
J. Biol. Chem. 283, 25988-25999
   Abstract »    Full Text »    PDF »
C. elegans dauer formation and the molecular basis of plasticity.
N. Fielenbach and A. Antebi (2008)
Genes & Dev. 22, 2149-2165
   Abstract »    Full Text »    PDF »
Elongation and Desaturation of Fatty Acids are Critical in Growth, Lipid Metabolism and Ontogeny of Caenorhabditis elegans.
M. Horikawa, T. Nomura, T. Hashimoto, and K. Sakamoto (2008)
J. Biochem. 144, 149-158
   Abstract »    Full Text »    PDF »
Wnt Signaling Inhibits Forkhead Box O3a-induced Transcription and Apoptosis through Up-regulation of Serum- and Glucocorticoid-inducible Kinase 1.
M. Dehner, M. Hadjihannas, J. Weiske, O. Huber, and J. Behrens (2008)
J. Biol. Chem. 283, 19201-19210
   Abstract »    Full Text »    PDF »
Welcoming {beta}-Catenin to the Gonadotropin-Releasing Hormone Transcriptional Network in Gonadotropes.
T. B. Salisbury, A. K. Binder, and J. H. Nilson (2008)
Mol. Endocrinol. 22, 1295-1303
   Abstract »    Full Text »    PDF »
Superoxide Destabilization of {beta}-Catenin Augments Apoptosis of High-Glucose-Stressed Mesangial Cells.
C.-L. Lin, J.-Y. Wang, J.-Y. Ko, K. Surendran, Y.-T. Huang, Y.-H. Kuo, and F.-S. Wang (2008)
Endocrinology 149, 2934-2942
   Abstract »    Full Text »    PDF »
Interaction of FOXO with {beta}-Catenin Inhibits {beta}-Catenin/T Cell Factor Activity.
D. Hoogeboom, M. A. G. Essers, P. E. Polderman, E. Voets, L. M. M. Smits, and B. M. Th. Burgering (2008)
J. Biol. Chem. 283, 9224-9230
   Abstract »    Full Text »    PDF »
Forkhead Transcription Factors and Cardiovascular Biology.
K. N. Papanicolaou, Y. Izumiya, and K. Walsh (2008)
Circ. Res. 102, 16-31
   Abstract »    Full Text »    PDF »
Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.
M. Dixit, E. Bess, B. Fisslthaler, F. V. Hartel, T. Noll, R. Busse, and I. Fleming (2008)
Cardiovasc Res 77, 160-168
   Abstract »    Full Text »    PDF »
Differential Control of Wnt Target Genes Involves Epigenetic Mechanisms and Selective Promoter Occupancy by T-Cell Factors.
S. Wohrle, B. Wallmen, and A. Hecht (2007)
Mol. Cell. Biol. 27, 8164-8177
   Abstract »    Full Text »    PDF »
A food's-eye view of the transition from basal metazoans to bilaterians.
N. W. Blackstone (2007)
Integr. Comp. Biol. 47, 724-733
   Abstract »    Full Text »    PDF »
Gone with the Wnts: {beta}-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism.
S. C. Manolagas and M. Almeida (2007)
Mol. Endocrinol. 21, 2605-2614
   Abstract »    Full Text »    PDF »
Complex N-Glycan and Metabolic Control in Tumor Cells.
R. Mendelsohn, P. Cheung, L. Berger, E. Partridge, K. Lau, A. Datti, J. Pawling, and J. W. Dennis (2007)
Cancer Res. 67, 9771-9780
   Abstract »    Full Text »    PDF »
Transcriptional Cross Talk between the Forkhead Transcription Factor Forkhead Box O1A and the Progesterone Receptor Coordinates Cell Cycle Regulation and Differentiation in Human Endometrial Stromal Cells.
M. Takano, Z. Lu, T. Goto, L. Fusi, J. Higham, J. Francis, A. Withey, J. Hardt, B. Cloke, A. V. Stavropoulou, et al. (2007)
Mol. Endocrinol. 21, 2334-2349
   Abstract »    Full Text »    PDF »
Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting beta-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription.
M. Almeida, L. Han, M. Martin-Millan, C. A. O'Brien, and S. C. Manolagas (2007)
J. Biol. Chem. 282, 27298-27305
   Abstract »    Full Text »    PDF »
Dynamic FoxO transcription factors.
H. Huang and D. J. Tindall (2007)
J. Cell Sci. 120, 2479-2487
   Abstract »    Full Text »    PDF »
Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity.
M. D Rudd, I. Gonzalez-Robayna, I. Hernandez-Gonzalez, N. L Weigel, W. E Bingman III, and J. S Richards (2007)
J. Mol. Endocrinol. 38, 673-690
   Abstract »    Full Text »    PDF »
FOXO Transcription Factors in the Regulatory Networks of Longevity.
H. Daitoku and A. Fukamizu (2007)
J. Biochem. 141, 769-774
   Abstract »    Full Text »    PDF »
Differential Regulation of Foxo3a Target Genes in Erythropoiesis.
W. J. Bakker, T. B. van Dijk, M. Parren-van Amelsvoort, A. Kolbus, K. Yamamoto, P. Steinlein, R. G. W. Verhaak, T. W. Mak, H. Beug, B. Lowenberg, et al. (2007)
Mol. Cell. Biol. 27, 3839-3854
   Abstract »    Full Text »    PDF »
The emerging role of FOXO transcription factors in pancreatic {beta} cells.
D. A Glauser and W. Schlegel (2007)
J. Endocrinol. 193, 195-207
   Abstract »    Full Text »    PDF »
Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells.
G. S. Yochum, S. McWeeney, V. Rajaraman, R. Cleland, S. Peters, and R. H. Goodman (2007)
PNAS 104, 3324-3329
   Abstract »    Full Text »    PDF »
The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling.
A. Bosque, J. I. Aguilo, M. A. Alava, E. Paz-Artal, J. Naval, L. M. Allende, and A. Anel (2007)
Blood 109, 1627-1635
   Abstract »    Full Text »    PDF »
Down-regulation of Manganese-Superoxide Dismutase through Phosphorylation of FOXO3a by Akt in Explanted Vascular Smooth Muscle Cells from Old Rats.
M. Li, J.-F. Chiu, B. T. Mossman, and N. K. Fukagawa (2006)
J. Biol. Chem. 281, 40429-40439
   Abstract »    Full Text »    PDF »
Chronic Protein Kinase B (PKB/c-akt) Activation Leads to Apoptosis Induced by Oxidative Stress-Mediated Foxo3a Transcriptional Up-regulation..
A. G.M. van Gorp, K. M. Pomeranz, K. U. Birkenkamp, R. C-Y. Hui, E. W-F. Lam, and P. J. Coffer (2006)
Cancer Res. 66, 10760-10769
   Abstract »    Full Text »    PDF »
Endocrine signaling in Caenorhabditis elegans controls stress response and longevity..
R. Baumeister, E. Schaffitzel, and M. Hertweck (2006)
J. Endocrinol. 190, 191-202
   Abstract »    Full Text »    PDF »
G1/S Arrest Induced by Histone Deacetylase Inhibitor Sodium Butyrate in E1A + Ras-transformed Cells Is Mediated through Down-regulation of E2F Activity and Stabilization of beta-Catenin.
M. V. Abramova, T. V. Pospelova, F. P. Nikulenkov, C. M. Hollander, A. J. Fornace Jr., and V. A. Pospelov (2006)
J. Biol. Chem. 281, 21040-21051
   Abstract »    Full Text »    PDF »
Regulation of Human Nitric Oxide Synthase 2 Expression by Wnt {beta}-Catenin Signaling..
Q. Du, K. S. Park, Z. Guo, P. He, M. Nagashima, L. Shao, R. Sahai, D. A. Geller, and S. P. Hussain (2006)
Cancer Res. 66, 7024-7031
   Abstract »    Full Text »    PDF »
The Heat-Shock Protein Apg-2 Binds to the Tight Junction Protein ZO-1 and Regulates Transcriptional Activity of ZONAB.
A. Tsapara, K. Matter, and M. S. Balda (2006)
Mol. Biol. Cell 17, 1322-1330
   Abstract »    Full Text »    PDF »
RUNX3 Cooperates with FoxO3a to Induce Apoptosis in Gastric Cancer Cells.
Y. Yamamura, W. L. Lee, K.-i. Inoue, H. Ida, and Y. Ito (2006)
J. Biol. Chem. 281, 5267-5276
   Abstract »    Full Text »    PDF »
Soluble IGF2 Receptor Rescues ApcMin/+ Intestinal Adenoma Progression Induced by Igf2 Loss of Imprinting.
J. Harper, J. L. Burns, E. J. Foulstone, M. Pignatelli, S. Zaina, and A. B. Hassan (2006)
Cancer Res. 66, 1940-1948
   Abstract »    Full Text »    PDF »
Regulation of Oxidative Stress by the Anti-aging Hormone Klotho.
M. Yamamoto, J. D. Clark, J. V. Pastor, P. Gurnani, A. Nandi, H. Kurosu, M. Miyoshi, Y. Ogawa, D. H. Castrillon, K. P. Rosenblatt, et al. (2005)
J. Biol. Chem. 280, 38029-38034
   Abstract »    Full Text »    PDF »
Dietary Components Modify Gene Expression: Implications for Carcinogenesis.
K. Yang, W. Yang, J. Mariadason, A. Velcich, M. Lipkin, and L. Augenlicht (2005)
J. Nutr. 135, 2710-2714
   Abstract »    Full Text »    PDF »
{beta}-Catenin, Cancer, and G Proteins: Not Just for Frizzleds Anymore.
C. C. Malbon (2005)
Sci. STKE 2005, pe35
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)