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Salmonella enterica causes a variety of diseases, includinggastroenteritis and typhoid fever. The success of this pathogendepends on its capacity to proliferate within host cells ina membrane-bound compartment. We found that the Salmonella-containingvacuole recruited the plus-end–directed motor kinesin.Bacterial effector proteins translocated into the host cellby a type III secretion system antagonistically regulated thisevent. Among these effectors, SifA targeted SKIP, a host proteinthat down-regulated the recruitment of kinesin on the bacterialvacuole and, in turn, controlled vacuolar membrane dynamics.
1 Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906-13288 Marseille Cedex 9, France. 2 Molecular Pharmacology, UMR 599 INSERM, and Institut Paoli-Calmettes, 27 Boulevard Leï Roure, 13009 Marseille, France.
* To whom correspondence should be addressed. E-mail: meresse{at}ciml.univ-mrs.fr
Role for Myosin II in Regulating Positioning of Salmonella-Containing Vacuoles and Intracellular Replication.
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76, 2722-2735
|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
Type III Secretion Systems and Disease.
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20, 535-549
|Abstract »|Full Text »|PDF »
Rapid Escape of the dot/icm Mutants of Legionella pneumophila into the Cytosol of Mammalian and Protozoan Cells.
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Infect. Immun.
75, 3290-3304
|Abstract »|Full Text »|PDF »
Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infection.
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PNAS
104, 11038-11043
|Abstract »|Full Text »|PDF »
The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication Niche.
J. Deiwick, S. P. Salcedo, E. Boucrot, S. M. Gilliland, T. Henry, N. Petermann, S. R. Waterman, J.-P. Gorvel, D. W. Holden, and S. Meresse (2006)
Infect. Immun.
74, 6965-6972
|Abstract »|Full Text »|PDF »
The Salmonella effector protein PipB2 is a linker for kinesin-1.
T. Henry, C. Couillault, P. Rockenfeller, E. Boucrot, A. Dumont, N. Schroeder, A. Hermant, L. A. Knodler, P. Lecine, O. Steele-Mortimer, et al. (2006)
PNAS
103, 13497-13502
|Abstract »|Full Text »|PDF »
Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function..
N. F. Brown, J. Szeto, X. Jiang, B. K. Coombes, B. B. Finlay, and J. H. Brumell (2006)
Microbiology
152, 2323-2343
|Abstract »|Full Text »|PDF »
Towards an understanding of kinesin-1 dependent transport pathways through the study of protein-protein interactions.
