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Induction of Protein Secretory Pathway Is Required for Systemic Acquired Resistance
Dong Wang,Natalie D. Weaver,Meenu Kesarwani,*Xinnian Dong
In plants, systemic acquired resistance (SAR) is establishedas a result of NPR1-regulated expression of pathogenesis-related(PR) genes. Using gene expression profiling in Arabidopsis,we found that in addition to controlling the expression of PRgenes, NPR1 also directly controls the expression of the proteinsecretory pathway genes. Up-regulation of these genes is essentialfor SAR, because mutations in some of them diminished the secretionof PR proteins (for example, PR1), resulting in reduced resistance.We provide evidence that NPR1 coordinately regulates these secretion-relatedgenes through a previously undescribed cis-element. Activationof this cis-element is controlled by a transcription factorthat is translocated into the nucleus upon SAR induction.
Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA.
* Present address: Massachusetts General Hospital, Departmentof Surgery, Boston, MA 02114, USA.
To whom correspondence should be addressed. E-mail: xdong{at}duke.edu
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