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Science 13 May 2005:
Vol. 308. no. 5724, pp. 1036 - 1040
DOI: 10.1126/science.1108791
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Reports

Induction of Protein Secretory Pathway Is Required for Systemic Acquired Resistance

Dong Wang, Natalie D. Weaver, Meenu Kesarwani,* Xinnian Dong{dagger}

In plants, systemic acquired resistance (SAR) is established as a result of NPR1-regulated expression of pathogenesis-related (PR) genes. Using gene expression profiling in Arabidopsis, we found that in addition to controlling the expression of PR genes, NPR1 also directly controls the expression of the protein secretory pathway genes. Up-regulation of these genes is essential for SAR, because mutations in some of them diminished the secretion of PR proteins (for example, PR1), resulting in reduced resistance. We provide evidence that NPR1 coordinately regulates these secretion-related genes through a previously undescribed cis-element. Activation of this cis-element is controlled by a transcription factor that is translocated into the nucleus upon SAR induction.

Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA.

* Present address: Massachusetts General Hospital, Department of Surgery, Boston, MA 02114, USA.

{dagger} To whom correspondence should be addressed. E-mail: xdong{at}duke.edu

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