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Originally published in Science Express on 17 March 2005
Science 6 May 2005:
Vol. 308. no. 5723, pp. 833 - 838
DOI: 10.1126/science.1109020

Research Articles

MicroRNAs Regulate Brain Morphogenesis in Zebrafish

Antonio J. Giraldez,1* Ryan M. Cinalli,1 Margaret E. Glasner,2{dagger} Anton J. Enright,3 J. Michael Thomson,4 Scott Baskerville,2 Scott M. Hammond,4 David P. Bartel,2 Alexander F. Schier1*

MicroRNAs (miRNAs) are small RNAs that regulate gene expression posttranscriptionally. To block all miRNA formation in zebrafish, we generated maternal-zygotic dicer (MZdicer) mutants that disrupt the Dicer ribonuclease III and double-stranded RNA-binding domains. Mutant embryos do not process precursor miRNAs into mature miRNAs, but injection of preprocessed miRNAs restores gene silencing, indicating that the disrupted domains are dispensable for later steps in silencing. MZdicer mutants undergo axis formation and differentiate multiple cell types but display abnormal morphogenesis during gastrulation, brain formation, somitogenesis, and heart development. Injection of miR-430 miRNAs rescues the brain defects in MZdicer mutants, revealing essential roles for miRNAs during morphogenesis.

1 Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
2 Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.
3 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
4 Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Published online 17 March 2005

Include this information when citing this paper.

{dagger} Present address: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, Box 2240, San Francisco, CA 94143-2240, USA.

* To whom correspondence should be addressed. E-mail: schier{at}saturn.med.nyu.edu (A.F.S.); giraldez{at}saturn.med.nyu.edu (A.J.G.)

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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. W. Padgett and M. Reiss (2007)
Development 134, 3565-3569
   Abstract »    Full Text »    PDF »
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W.-Y. Choi, A. J. Giraldez, and A. F. Schier (2007)
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   Abstract »    Full Text »    PDF »
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T. Thum, P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, L. W. van Laake, P. A. Doevendans, C. L. Mummery, J. Borlak, A. Haverich, et al. (2007)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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P. B. Antin, S. Kaur, S. Stanislaw, S. Davey, J. H. Konieczka, T. A. Yatskievych, and D. K. Darnell (2007)
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   Abstract »    Full Text »    PDF »
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P. Laneve, L. Di Marcotullio, U. Gioia, M. E. Fiori, E. Ferretti, A. Gulino, I. Bozzoni, and E. Caffarelli (2007)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Exp. Biol. 210, 1526-1547
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Distance constraints between microRNA target sites dictate efficacy and cooperativity.
P. Saetrom, B. S.E. Heale, O. Snove Jr, L. Aagaard, J. Alluin, and J. J. Rossi (2007)
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   Abstract »    Full Text »    PDF »
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F. Tang, M. Kaneda, D. O'Carroll, P. Hajkova, S. C. Barton, Y. A. Sun, C. Lee, A. Tarakhovsky, K. Lao, and M. A. Surani (2007)
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   Abstract »    Full Text »    PDF »
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E. P. Murchison, P. Stein, Z. Xuan, H. Pan, M. Q. Zhang, R. M. Schultz, and G. J. Hannon (2007)
Genes & Dev. 21, 682-693
   Abstract »    Full Text »    PDF »
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L. L. Coutinho, L. K. Matukumalli, T. S. Sonstegard, C. P. Van Tassell, L. C. Gasbarre, A. V. Capuco, and T. P. L. Smith (2007)
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   Abstract »    Full Text »    PDF »
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X. Cao, S. L. Pfaff, and F. H. Gage (2007)
Genes & Dev. 21, 531-536
   Abstract »    Full Text »    PDF »
RNAi pathway is functional in peripheral nerve axons.
A. K. Murashov, V. Chintalgattu, R. R. Islamov, T. E. Lever, E. S. Pak, P. L. Sierpinski, L. C. Katwa, and M. R. Van Scott (2007)
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   Abstract »    Full Text »    PDF »
Post-transcriptional regulation of the let-7 microRNA during neural cell specification.
F. G. Wulczyn, L. Smirnova, A. Rybak, C. Brandt, E. Kwidzinski, O. Ninnemann, M. Strehle, A. Seiler, S. Schumacher, and R. Nitsch (2007)
FASEB J 21, 415-426
   Abstract »    Full Text »    PDF »
Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos.
Z. Yu, Z. Jian, S.-H. Shen, E. Purisima, and E. Wang (2007)
Nucleic Acids Res. 35, 152-164
   Abstract »    Full Text »    PDF »
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development.
P. L. Boutz, G. Chawla, P. Stoilov, and D. L. Black (2007)
Genes & Dev. 21, 71-84
   Abstract »    Full Text »    PDF »
A Restricted Role for Sperm-Borne MicroRNAs in Mammalian Fertilization.
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Biol Reprod 75, 877-884
   Abstract »    Full Text »    PDF »
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M. Arteaga-Vazquez, J. Caballero-Perez, and J.-P. Vielle-Calzada (2006)
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   Abstract »    Full Text »    PDF »
MicroRNAs: regulators of gene expression and cell differentiation.
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Blood 108, 3646-3653
   Abstract »    Full Text »    PDF »
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A. Hossain, M. T. Kuo, and G. F. Saunders (2006)
Mol. Cell. Biol. 26, 8191-8201
   Abstract »    Full Text »    PDF »
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B. S. Cobb, A. Hertweck, J. Smith, E. O'Connor, D. Graf, T. Cook, S. T. Smale, S. Sakaguchi, F. J. Livesey, A. G. Fisher, et al. (2006)
J. Exp. Med. 203, 2519-2527
   Abstract »    Full Text »    PDF »
MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila.
Y. Li, F. Wang, J.-A Lee, and F.-B. Gao (2006)
Genes & Dev. 20, 2793-2805
   Abstract »    Full Text »    PDF »
Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development.
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Development 133, 3461-3471
   Abstract »    Full Text »    PDF »
Non-coding RNAs in the nervous system.
M. F. Mehler and J. S. Mattick (2006)
J. Physiol. 575, 333-341
   Abstract »    Full Text »    PDF »
The regulated expression of chimeric tyrosine hydroxylase-insulin transcripts during early development.
C. Hernandez-Sanchez, O. Bartulos, A. I. Valenciano, A. Mansilla, and F. de Pablo (2006)
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   Abstract »    Full Text »    PDF »
Myogenic factors that regulate expression of muscle-specific microRNAs.
P. K. Rao, R. M. Kumar, M. Farkhondeh, S. Baskerville, and H. F. Lodish (2006)
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 26, 5727-5732
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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