Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 April 2005:
Vol. 308. no. 5720, pp. 381 - 385
DOI: 10.1126/science.1107573
Prev | Table of Contents | Next

Research Articles

An Epidermal Barrier Wound Repair Pathway in Drosophila Is Mediated by grainy head

Kimberly A. Mace,* Joseph C. Pearson, William McGinnis{dagger}

We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier.

Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA.

* Present address: Surgical Research Laboratory, University of California, San Francisco, CA 94143-1302, USA.

{dagger} To whom correspondence should be addressed. E-mail: wmcginnis{at}ucsd.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Scab formation and wound healing of plant tissue by soldier aphid.
M. Kutsukake, H. Shibao, K. Uematsu, and T. Fukatsu (2009)
Proc R Soc B 276, 1555-1563
   Abstract »    Full Text »    PDF »
Multiple transcription factor codes activate epidermal wound-response genes in Drosophila.
J. C. Pearson, M. T. Juarez, M. Kim, O. Drivenes, and W. McGinnis (2009)
PNAS 106, 2224-2229
   Abstract »    Full Text »    PDF »
Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.
A. Tong, G. Lynn, V. Ngo, D. Wong, S. L. Moseley, J. J. Ewbank, A. Goncharov, Y.-C. Wu, N. Pujol, and A. D. Chisholm (2009)
PNAS 106, 1457-1461
   Abstract »    Full Text »    PDF »
A Member of the p38 Mitogen-Activated Protein Kinase Family Is Responsible for Transcriptional Induction of Dopa decarboxylase in the Epidermis of Drosophila melanogaster during the Innate Immune Response.
M. M. Davis, D. A. Primrose, and R. B. Hodgetts (2008)
Mol. Cell. Biol. 28, 4883-4895
   Abstract »    Full Text »    PDF »
Genomic Survey of Candidate Stress-Response Genes in the Estuarine Anemone Nematostella vectensis.
A. M. Reitzel, J. C. Sullivan, N. Traylor-knowles, and J. R. Finnerty (2008)
Biol. Bull. 214, 233-254
   Abstract »    Full Text »    PDF »
Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis.
M. Narasimha, A. Uv, A. Krejci, N. H. Brown, and S. J. Bray (2008)
J. Cell Sci. 121, 747-752
   Abstract »    Full Text »    PDF »
A Cysteine-rich Protein from an Arthropod Stabilizes Clotting Mesh and Immobilizes Bacteria at Injury Sites.
Y. Matsuda, T. Osaki, T. Hashii, T. Koshiba, and S.-i. Kawabata (2007)
J. Biol. Chem. 282, 33545-33552
   Abstract »    Full Text »    PDF »
Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.
Y. Yamaguchi, S. Yonemura, and S. Takada (2006)
Development 133, 4737-4748
   Abstract »    Full Text »    PDF »
Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism.
L.-C. Yao, I. L. Blitz, D. A. Peiffer, S. Phin, Y. Wang, S. Ogata, K. W. Y. Cho, K. Arora, and R. Warrior (2006)
Development 133, 4025-4034
   Abstract »    Full Text »    PDF »
A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice.
S. B. Ting, J. Caddy, N. Hislop, T. Wilanowski, A. Auden, L.-l. Zhao, S. Ellis, P. Kaur, Y. Uchida, W. M. Holleran, et al. (2005)
Science 308, 411-413
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)