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Postsynaptic Receptor Trafficking Underlying a Form of Associative Learning
Simon Rumpel,1Joseph LeDoux,2Anthony Zador,1Roberto Malinow1*
To elucidate molecular, cellular, and circuit changes that occurin the brain during learning, we investigated the role of aglutamate receptor subtype in fear conditioning. In this formof learning, animals associate two stimuli, such as a tone anda shock. Here we report that fear conditioning drives AMPA-typeglutamate receptors into the synapse of a large fraction ofpostsynaptic neurons in the lateral amygdala, a brain structureessential for this learning process. Furthermore, memory wasreduced if AMPA receptor synaptic incorporation was blockedin as few as 10 to 20% of lateral amygdala neurons. Thus, theencoding of memories in the lateral amygdala is mediated byAMPA receptor trafficking, is widely distributed, and displayslittle redundancy.
1 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. 2 New York University, New York, NY 10003, USA.
* To whom correspondence should be addressed. E-mail: malinow{at}cshl.edu
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