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Extrusion of Cells with Inappropriate Dpp Signaling from Drosophila Wing Disc Epithelia
Jie Shen and
Christian Dahmann*
Decapentaplegic (Dpp) is a signaling molecule that controlsgrowth and patterning of the developing Drosophila wing. Mutantcells lacking Dpp signal transduction have been shown to activatec-Jun amino-terminal kinase (JNK)–dependent apoptosisand to be lost from the wing disc epithelium. These observationshave led to the hypothesis that Dpp promotes cell survival bypreventing apoptosis. Here, we show that in the absence of JNK-dependentapoptosis, mutant cells lacking Dpp signal transduction cansurvive; however, they are still lost from the wing disc epithelium.This loss correlates with extensive cytoskeletal changes followedby basal epithelial extrusion. We propose that Dpp promotescell survival within disc epithelia by affecting cytoskeletalorganization.
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
* To whom correspondence should be addressed. E-mail: dahmann{at}mpi-cbg.de
Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.
D. C. Goldman, R. Hackenmiller, T. Nakayama, S. Sopory, C. Wong, H. Kulessa, and J. L. Christian (2006)
Development
133, 1933-1942
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