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Fat tissue produces a variety of secreted proteins (adipocytokines)with important roles in metabolism. We isolated a newly identifiedadipocytokine, visfatin, that is highly enriched in the visceralfat of both humans and mice and whose expression level in plasmaincreases during the development of obesity. Visfatin correspondsto a protein identified previously as pre–B cell colony-enhancingfactor (PBEF), a 52-kilodalton cytokine expressed in lymphocytes.Visfatin exerted insulin-mimetic effects in cultured cells andlowered plasma glucose levels in mice. Mice heterozygous fora targeted mutation in the visfatin gene had modestly higherlevels of plasma glucose relative to wild-type littermates.Surprisingly, visfatin binds to and activates the insulin receptor.Further study of visfatin's physiological role may lead to newinsights into glucose homeostasis and/or new therapies for metabolicdisorders such as diabetes.
1 Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. 2 Japan Society for the Promotion of Science, Ichibancho, Chiyoda-ku, Tokyo 102-8471, Japan. 3 Genomic Science Laboratories, Sumitomo Pharmaceuticals Co. Ltd., 2-1, Takatsukasa 4-Chome, Takarazuka, Hyogo 665-0051, Japan. 4 CREST, JST, Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan. 5 Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. 6 Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-Ku, Osaka, 530-0005, Japan. 7 PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: ichi{at}imed2.med.osaka-u.ac.jp
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases.
R. Gomez, F. Lago, J. Gomez-Reino, C. Dieguez, and O. Gualillo (2009)
J. Mol. Endocrinol.
43, 11-18
|Abstract »|Full Text »|PDF »
Visfatin: The Link Between Inflammation and Childhood Obesity.
G. V.Z. Dedoussis, A. Kapiri, A. Samara, D. Dimitriadis, D. Lambert, M. Pfister, G. Siest, and S. Visvikis-Siest (2009)
Diabetes Care
32, e71
|Full Text »|PDF »
Getting the message across: mechanisms of physiological cross talk by adipose tissue.
D.-E. Lee, S. Kehlenbrink, H. Lee, M. Hawkins, and J. S. Yudkin (2009)
Am J Physiol Endocrinol Metab
296, E1210-E1229
|Abstract »|Full Text »|PDF »
Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis.
F. Lovren, Y. Pan, P. C. Shukla, A. Quan, H. Teoh, P. E. Szmitko, M. D. Peterson, M. Gupta, M. Al-Omran, and S. Verma (2009)
Am J Physiol Endocrinol Metab
296, E1440-E1449
|Abstract »|Full Text »|PDF »
Active visfatin is elevated in serum of maintenance haemodialysis patients and correlates inversely with circulating HDL cholesterol.
K.-D. Nusken, M. Petrasch, M. Rauh, W. Stohr, E. Nusken, H. Schneider, and J. Dotsch (2009)
Nephrol. Dial. Transplant.
|Abstract »|Full Text »|PDF »
Adipokines and the clinical laboratory: what to measure, when and how?.
Relationship Between Cerebrospinal Fluid Visfatin (PBEF/Nampt) Levels and Adiposity in Humans.
M. Hallschmid, H. Randeva, B. K. Tan, W. Kern, and H. Lehnert (2009)
Diabetes
58, 637-640
|Abstract »|Full Text »|PDF »
Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis.
J. F. de Boer, M. J. Bahr, K. H. W. Boker, M. P. Manns, and U. J. F. Tietge (2009)
Am J Physiol Gastrointest Liver Physiol
296, G196-G201
|Abstract »|Full Text »|PDF »
Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.
S. C. Gunawardana, R. K. P. Benninger, and D. W. Piston (2009)
Am J Physiol Endocrinol Metab
296, E323-E332
|Abstract »|Full Text »|PDF »
Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism.
Y. Li, Y. Zhang, B. Dorweiler, D. Cui, T. Wang, C. W. Woo, C. S. Brunkan, C. Wolberger, S.-i. Imai, and I. Tabas (2008)
J. Biol. Chem.
283, 34833-34843
|Abstract »|Full Text »|PDF »
The Metabolic Syndrome.
M.-A. Cornier, D. Dabelea, T. L. Hernandez, R. C. Lindstrom, A. J. Steig, N. R. Stob, R. E. Van Pelt, H. Wang, and R. H. Eckel (2008)
Endocr. Rev.
29, 777-822
|Abstract »|Full Text »|PDF »
Fasting regulates the expression of adiponectin receptors in young growing pigs.
B. H. Liu, P. H. Wang, Y. C. Wang, W. M. Cheng, H. J. Mersmann, and S. T. Ding (2008)
J Anim Sci
86, 3377-3384
|Abstract »|Full Text »|PDF »
Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease.
A. Shah, N. Mehta, and M. P. Reilly (2008)
JPEN J Parenter Enteral Nutr
32, 638-644
|Abstract »|Full Text »|PDF »
Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control.
S. M. Dupre, D. W. Burt, R. Talbot, A. Downing, D. Mouzaki, D. Waddington, B. Malpaux, J. R. E. Davis, G. A. Lincoln, and A. S. I. Loudon (2008)
Endocrinology
149, 5527-5539
|Abstract »|Full Text »|PDF »
Visfatin: a new player in mesangial cell physiology and diabetic nephropathy.
H. K. Song, M. H. Lee, B. K. Kim, Y. G. Park, G. J. Ko, Y. S. Kang, J. Y. Han, S. Y. Han, K. H. Han, H. K. Kim, et al. (2008)
Am J Physiol Renal Physiol
295, F1485-F1494
|Abstract »|Full Text »|PDF »
Adipocytokines and the Metabolic Complications of Obesity.
HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options.
J. E. Mallewa, E. Wilkins, J. Vilar, M. Mallewa, D. Doran, D. Back, and M. Pirmohamed (2008)
J. Antimicrob. Chemother.
62, 648-660
|Abstract »|Full Text »|PDF »
The emerging biology of adipose tissue in chronic kidney disease: from fat to facts.
J. Axelsson (2008)
Nephrol. Dial. Transplant.
23, 3041-3046
|Full Text »|PDF »
Essential Role of Pre-B-Cell Colony Enhancing Factor in Ventilator-induced Lung Injury.
S.-B. Hong, Y. Huang, L. Moreno-Vinasco, S. Sammani, J. Moitra, J. W. Barnard, S.-F. Ma, T. Mirzapoiazova, C. Evenoski, R. R. Reeves, et al. (2008)
Am. J. Respir. Crit. Care Med.
178, 605-617
|Abstract »|Full Text »|PDF »
Adaptation and Maladaptation of the Heart in Obesity.
R. Harmancey, C. R. Wilson, and H. Taegtmeyer (2008)
Hypertension
52, 181-187
|Full Text »|PDF »
Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin.
M. I. Yilmaz, M. Saglam, A. R. Qureshi, J. J. Carrero, K. Caglar, T. Eyileten, A. Sonmez, E. Cakir, Y. Oguz, A. Vural, et al. (2008)
Nephrol. Dial. Transplant.
23, 1621-1627
|Abstract »|Full Text »|PDF »
Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity.
Visfatin (pre-B cell colony-enhancing factor) gene expression in patients with rheumatoid arthritis.
H Matsui, A Tsutsumi, M Sugihara, T Suzuki, K Iwanami, M Kohno, D Goto, I Matsumoto, S Ito, and T Sumida (2008)
Ann Rheum Dis
67, 571-572
|Full Text »|PDF »
Serum visfatin concentration and endothelial dysfunction in chronic kidney disease.
M. I. Yilmaz, M. Saglam, J. J. Carrero, A. R. Qureshi, K. Caglar, T. Eyileten, A. Sonmez, E. Cakir, M. Yenicesu, B. Lindholm, et al. (2008)
Nephrol. Dial. Transplant.
23, 959-965
|Abstract »|Full Text »|PDF »
Endothelial dysfunction in CKD: a new player in town?.
C. Zoccali (2008)
Nephrol. Dial. Transplant.
23, 783-785
|Full Text »|PDF »
Uteroplacental Insufficiency after Bilateral Uterine Artery Ligation in the Rat: Impact on Postnatal Glucose and Lipid Metabolism and Evidence for Metabolic Programming of the Offspring by Sham Operation.
K.-D. Nusken, J. Dotsch, M. Rauh, W. Rascher, and H. Schneider (2008)
Endocrinology
149, 1056-1063
|Abstract »|Full Text »|PDF »
Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease.
K M Choi, J S Lee, E J Kim, S H Baik, H S Seo, D S Choi, D J Oh, and C G Park (2008)
Eur. J. Endocrinol.
158, 203-207
|Abstract »|Full Text »|PDF »
Obesity, Inflammation, and the Potential Application of Pharmaconutrition.
M. C. Cave, R. T. Hurt, T. H. Frazier, P. J. Matheson, R. N. Garrison, C. J. McClain, and S. A. McClave (2008)
Nutr Clin Pract
23, 16-34
|Abstract »|Full Text »|PDF »
Molecular Characteristics of Serum Visfatin and Differential Detection by Immunoassays.
A. Korner, A. Garten, M. Bluher, R. Tauscher, J. Kratzsch, and W. Kiess (2007)
J. Clin. Endocrinol. Metab.
92, 4783-4791
|Abstract »|Full Text »|PDF »
Stretching, Mechanotransduction, and Proinflammatory Cytokines in the Fetal Membranes.
C. E. Kendal-Wright (2007)
Reproductive Sciences
14, 35-41
|Abstract »|PDF »
Effect of exercise training on plasma visfatin and eotaxin levels.
K M Choi, J H Kim, G J Cho, S H Baik, H S Park, and S M Kim (2007)
Eur. J. Endocrinol.
157, 437-442
|Abstract »|Full Text »|PDF »
The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance.
Q.-W. Yan, Q. Yang, N. Mody, T. E. Graham, C.-H. Hsu, Z. Xu, N. E. Houstis, B. B. Kahn, and E. D. Rosen (2007)
Diabetes
56, 2533-2540
|Abstract »|Full Text »|PDF »
Subcutaneous Fat Accumulation Shows a Beneficial Correlation with Serum Cholesterol in Postmenopausal Japanese Women.
M. Tanaka, R. Koga, H. Tsuda, K. Imai, S. Abe, T. Masuda, M. Iwamoto, E. Nakazono, T. Kamohara, N. Kinukawa, et al. (2007)
Experimental Biology and Medicine
232, 1064-1070
|Abstract »|Full Text »|PDF »
Coculture with Primary Visceral Rat Adipocytes from Control But Not Streptozotocin-Induced Diabetic Animals Increases Glucose Uptake in Rat Skeletal Muscle Cells: Role of Adiponectin.
V. Vu, W. Kim, X. Fang, Y.-T. Liu, A. Xu, and G. Sweeney (2007)
Endocrinology
148, 4411-4419
|Abstract »|Full Text »|PDF »
Local adipose tissue depots as cardiovascular risk factors.
Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells.
N. Hara, K. Yamada, T. Shibata, H. Osago, T. Hashimoto, and M. Tsuchiya (2007)
J. Biol. Chem.
282, 24574-24582
|Abstract »|Full Text »|PDF »
Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat.
T. Josephs, H. Waugh, I. Kokay, D. Grattan, and M. Thompson (2007)
J. Endocrinol.
194, 305-312
|Abstract »|Full Text »|PDF »
Association of Serum Retinol-Binding Protein 4 and Visceral Adiposity in Chinese Subjects with and without Type 2 Diabetes.
W. Jia, H. Wu, Y. Bao, C. Wang, J. Lu, J. Zhu, and K. Xiang (2007)
J. Clin. Endocrinol. Metab.
92, 3224-3229
|Abstract »|Full Text »|PDF »
The Role of Adipocytokines in Insulin Resistance in Normal Pregnancy: Visfatin Concentrations in Early Pregnancy Predict Insulin Sensitivity.
G. Mastorakos, G. Valsamakis, D. C. Papatheodorou, I. Barlas, A. Margeli, A. Boutsiadis, E. Kouskouni, N. Vitoratos, A. Papadimitriou, I. Papassotiriou, et al. (2007)
Clin. Chem.
53, 1477-1483
|Abstract »|Full Text »|PDF »
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study.
C. S. Fox, J. M. Massaro, U. Hoffmann, K. M. Pou, P. Maurovich-Horvat, C.-Y. Liu, R. S. Vasan, J. M. Murabito, J. B. Meigs, L. A. Cupples, et al. (2007)
Circulation
116, 39-48
|Abstract »|Full Text »|PDF »
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome.
I. Kowalska, M. Straczkowski, A. Nikolajuk, A. Adamska, M. Karczewska-Kupczewska, E. Otziomek, S. Wolczynski, and M. Gorska (2007)
Hum. Reprod.
22, 1824-1829
|Abstract »|Full Text »|PDF »
Visfatin Response to Glucose Is Reduced in Women With Gestational Diabetes Mellitus.
D. G. Haider, A. Handisurya, A. Storka, E. Vojtassakova, A. Luger, G. Pacini, A. Tura, M. Wolzt, and A. Kautzky-Willer (2007)
Diabetes Care
30, 1889-1891
|Full Text »|PDF »
Perinatal Circulating Visfatin Levels in Intrauterine Growth Restriction.
A. Malamitsi-Puchner, D. D. Briana, M. Boutsikou, E. Kouskouni, D. Hassiakos, and D. Gourgiotis (2007)
Pediatrics
119, e1314-e1318
|Abstract »|Full Text »|PDF »
Obesity, Inflammation, and Periodontal Disease.
N. Pischon, N. Heng, J.-P. Bernimoulin, B.-M. Kleber, S.N. Willich, and T. Pischon (2007)
Journal of Dental Research
86, 400-409
|Abstract »|Full Text »|PDF »
Clinical Correlates of Circulating Visfatin Levels in a Community-Based Sample.
E. Ingelsson, M. G. Larson, C. S. Fox, X. Yin, T. J. Wang, I. Lipinska, K. M. Pou, U. Hoffmann, E. J. Benjamin, J. F. Keaney Jr., et al. (2007)
Diabetes Care
30, 1278-1280
|Full Text »|PDF »
Exogenous Insulin Use and Hypertension.
J. Oh, J. H. Chung, and Y. Jang (2007)
Arch Intern Med
167, 857-858
|Full Text »|PDF »
It Is Time We Ended the Myth of Insulin as an Atherogenic Hormone--Reply.
Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase.
E. van der Veer, C. Ho, C. O'Neil, N. Barbosa, R. Scott, S. P. Cregan, and J. G. Pickering (2007)
J. Biol. Chem.
282, 10841-10845
|Abstract »|Full Text »|PDF »
Defective Mitochondrial Biogenesis: A Hallmark of the High Cardiovascular Risk in the Metabolic Syndrome?.
E. Nisoli, E. Clementi, M. O. Carruba, and S. Moncada (2007)
Circ. Res.
100, 795-806
|Abstract »|Full Text »|PDF »
Circulating Visfatin Is Associated With Parameters of Iron Metabolism in Subjects With Altered Glucose Tolerance.
J. M. Fernandez-Real, J. M. Moreno, B. Chico, A. Lopez-Bermejo, and W. Ricart (2007)
Diabetes Care
30, 616-621
|Abstract »|Full Text »|PDF »
Adipocyte, Adipose Tissue, and Infectious Disease.
M. S. Desruisseaux, Nagajyothi, M. E. Trujillo, H. B. Tanowitz, and P. E. Scherer (2007)
Infect. Immun.
75, 1066-1078
|Full Text »|PDF »
Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization.
T. B. Dahl, A. Yndestad, M. Skjelland, E. Oie, A. Dahl, A. Michelsen, J. K. Damas, S. H. Tunheim, T. Ueland, C. Smith, et al. (2007)
Circulation
115, 972-980
|Abstract »|Full Text »|PDF »
Human Visfatin Expression: Relationship to Insulin Sensitivity, Intramyocellular Lipids, and Inflammation.
V. Varma, A. Yao-Borengasser, N. Rasouli, A. M. Bodles, B. Phanavanh, M.-J. Lee, T. Starks, L. M. Kern, H. J. Spencer III, R. E. McGehee Jr., et al. (2007)
J. Clin. Endocrinol. Metab.
92, 666-672
|Abstract »|Full Text »|PDF »
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties.
A. R. Moschen, A. Kaser, B. Enrich, B. Mosheimer, M. Theurl, H. Niederegger, and H. Tilg (2007)
J. Immunol.
178, 1748-1758
|Abstract »|Full Text »|PDF »
Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans.
Y. Wang, K. S. L. Lam, E. W. Kraegen, G. Sweeney, J. Zhang, A. W.K. Tso, W.-S. Chow, N. M.S. Wat, J. Y. Xu, R. L.C. Hoo, et al. (2007)
Clin. Chem.
53, 34-41
|Abstract »|Full Text »|PDF »
Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise.
L. Frydelund-Larsen, T. Akerstrom, S. Nielsen, P. Keller, C. Keller, and B. K. Pedersen (2007)
Am J Physiol Endocrinol Metab
292, E24-E31
|Abstract »|Full Text »|PDF »
Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells.
S. Ghosh, Y. Lu, A. Katz, Y. Hu, and R. Li (2007)
Am J Physiol Endocrinol Metab
292, E246-E252
|Abstract »|Full Text »|PDF »
Adipose Tissue-Derived Factors: Impact on Health and Disease.
Increased Visfatin Messenger Ribonucleic Acid and Protein Levels in Adipose Tissue and Adipocytes in Women with Polycystic Ovary Syndrome: Parallel Increase in Plasma Visfatin.
B. K. Tan, J. Chen, J. E. Digby, S. D. Keay, C. R. Kennedy, and H. S. Randeva (2006)
J. Clin. Endocrinol. Metab.
91, 5022-5028
|Abstract »|Full Text »|PDF »
Exercise Training Lowers Plasma Visfatin Concentrations in Patients with Type 1 Diabetes.
D. G. Haider, J. Pleiner, M. Francesconi, G. F. Wiesinger, M. Muller, and M. Wolzt (2006)
J. Clin. Endocrinol. Metab.
91, 4702-4704
|Abstract »|Full Text »|PDF »
Free fatty acids normalize a rosiglitazone-induced visfatin release.
D. G. Haider, F. Mittermayer, G. Schaller, M. Artwohl, S. M. Baumgartner-Parzer, G. Prager, M. Roden, and M. Wolzt (2006)
Am J Physiol Endocrinol Metab
291, E885-E890
|Abstract »|Full Text »|PDF »
Genetics of obesity and the prediction of risk for health.
A. J. Walley, A. I.F. Blakemore, and P. Froguel (2006)
Hum. Mol. Genet.
15, R124-R130
|Abstract »|Full Text »|PDF »
Hormonal activity of AIMP1/p43 for glucose homeostasis.
S. G. Park, Y. S. Kang, J. Y. Kim, C. S. Lee, Y. G. Ko, W. J. Lee, K.-U. Lee, Y. I. Yeom, and S. Kim (2006)
PNAS
103, 14913-14918
|Abstract »|Full Text »|PDF »
Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies.
J. L. Turgeon, M. C. Carr, P. M. Maki, M. E. Mendelsohn, and P. M. Wise (2006)
Endocr. Rev.
27, 575-605
|Abstract »|Full Text »|PDF »
Retinol-binding protein 4 in human obesity..
J. Janke, S. Engeli, M. Boschmann, F. Adams, J. Bohnke, F. C. Luft, A. M. Sharma, and J. Jordan (2006)
Diabetes
55, 2805-2810
|Abstract »|Full Text »|PDF »
Serum Visfatin Increases With Progressive {beta}-Cell Deterioration..
A. Lopez-Bermejo, B. Chico-Julia, M. Fernandez-Balsells, M. Recasens, E. Esteve, R. Casamitjana, W. Ricart, and J.-M. Fernandez-Real (2006)
Diabetes
55, 2871-2875
|Abstract »|Full Text »|PDF »
Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population..
S. D. Bailey, J C. Loredo-Osti, P. Lepage, J. Faith, J. Fontaine, K. M. Desbiens, T. J. Hudson, C. Bouchard, D. Gaudet, L. Perusse, et al. (2006)
Diabetes
55, 2896-2902
|Abstract »|Full Text »|PDF »
Obesity and Sepsis.
V. Vachharajani and S. Vital (2006)
J Intensive Care Med
21, 287-295
|Abstract »|PDF »
Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes.
Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.
M Otero, R Lago, R Gomez, F Lago, C Dieguez, J J Gomez-Reino, and O Gualillo (2006)
Ann Rheum Dis
65, 1198-1201
|Abstract »|Full Text »|PDF »
Role of Adipose Tissue as an Inflammatory Organ in Human Diseases.
A. Schaffler, U. Muller-Ladner, J. Scholmerich, and C. Buchler (2006)
Endocr. Rev.
27, 449-467
|Abstract »|Full Text »|PDF »
Reduced Plasma Visfatin/Pre-B Cell Colony-Enhancing Factor in Obesity Is Not Related to Insulin Resistance in Humans.
C. Pagano, C. Pilon, M. Olivieri, P. Mason, R. Fabris, R. Serra, G. Milan, M. Rossato, G. Federspil, and R. Vettor (2006)
J. Clin. Endocrinol. Metab.
91, 3165-3170
|Abstract »|Full Text »|PDF »
Decreased Plsma Visfatin Concentrations in Women With Gestational Diabetes Mellitus.
Genetic Variation in the Visfatin Gene (PBEF1) and Its Relation to Glucose Metabolism and Fat-Depot-Specific Messenger Ribonucleic Acid Expression in Humans.
Y. Bottcher, D. Teupser, B. Enigk, J. Berndt, N. Kloting, M. R. Schon, J. Thiery, M. Bluher, M. Stumvoll, and P. Kovacs (2006)
J. Clin. Endocrinol. Metab.
91, 2725-2731
|Abstract »|Full Text »|PDF »
Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ.
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
R.-Z. Yang, M.-J. Lee, H. Hu, J. Pray, H.-B. Wu, B. C. Hansen, A. R. Shuldiner, S. K. Fried, J. C. McLenithan, and D.-W. Gong (2006)
Am J Physiol Endocrinol Metab
290, E1253-E1261
|Abstract »|Full Text »|PDF »
Sex-Discordant Associations With Adiponectin Levels and Lipid Profiles in Children..
K. K. Ong, J. Frystyk, A. Flyvbjerg, C. J. Petry, the Avon Longitudinal Study of Parents and Childre, A. Ness, and D. B. Dunger (2006)
Diabetes
55, 1337-1341
|Abstract »|Full Text »|PDF »
The expression of genes related to adipocyte differentiation in pigs.
H. C. Wang, Y. H. Ko, H. J. Mersmann, C. L. Chen, and S. T. Ding (2006)
J Anim Sci
84, 1059-1066
|Abstract »|Full Text »|PDF »
Cytokines Promote Wnt Signaling and Inflammation and Impair the Normal Differentiation and Lipid Accumulation in 3T3-L1 Preadipocytes.
Increased Plasma Visfatin Concentrations in Morbidly Obese Subjects Are Reduced after Gastric Banding.
D. G. Haider, K. Schindler, G. Schaller, G. Prager, M. Wolzt, and B. Ludvik (2006)
J. Clin. Endocrinol. Metab.
91, 1578-1581
|Abstract »|Full Text »|PDF »
Visfatin Is an Adipokine, But It Is Not Regulated by Thiazolidinediones.
A. Hammarstedt, J. Pihlajamaki, V. Rotter Sopasakis, S. Gogg, P.-A. Jansson, M. Laakso, and U. Smith (2006)
J. Clin. Endocrinol. Metab.
91, 1181-1184
|Abstract »|Full Text »|PDF »
Editorial: Visfatin--A True Or False Trail To Type 2 Diabetes Mellitus.
P. Arner (2006)
J. Clin. Endocrinol. Metab.
91, 28-30
|Full Text »|PDF »
Elevated Plasma Level of Visfatin/Pre-B Cell Colony-Enhancing Factor in Patients with Type 2 Diabetes Mellitus.
M.-P. Chen, F.-M. Chung, D.-M. Chang, J. C.-R. Tsai, H.-F. Huang, S.-J. Shin, and Y.-J. Lee (2006)
J. Clin. Endocrinol. Metab.
91, 295-299
|Abstract »|Full Text »|PDF »
Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes.
F. Blaschke, Y. Takata, E. Caglayan, R. E. Law, and W. A. Hsueh (2006)
Arterioscler. Thromb. Vasc. Biol.
26, 28-40
|Abstract »|Full Text »|PDF »
Endothelial Cell IL-8, a New Target for Adiponectin: Implications in Vascular Protection.
Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity.
A. E Malavazos, E. Cereda, L. Morricone, C. Coman, M. M Corsi, and B. Ambrosi (2005)
Eur. J. Endocrinol.
153, 871-877
|Abstract »|Full Text »|PDF »
Rhythmic Messenger Ribonucleic Acid Expression of Clock Genes and Adipocytokines in Mouse Visceral Adipose Tissue.
H. Ando, H. Yanagihara, Y. Hayashi, Y. Obi, S. Tsuruoka, T. Takamura, S. Kaneko, and A. Fujimura (2005)
Endocrinology
146, 5631-5636
|Abstract »|Full Text »|PDF »
Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity.
C. Barandier, J.-P. Montani, and Z. Yang (2005)
Am J Physiol Heart Circ Physiol
289, H1807-H1813
|Abstract »|Full Text »|PDF »
Does visceral fat produce insulin?.
J. Dotsch, W. Rascher, and U. Meissner (2005)
Eur. J. Endocrinol.
153, 475-476
|Full Text »|PDF »
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