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Science 17 December 2004:
Vol. 306. no. 5704, pp. 2111 - 2115
DOI: 10.1126/science.1103709
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Reports

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Heather A. Arnett,1*{dagger} Stephen P. J. Fancy,2* John A. Alberta,1 Chao Zhao,2 Sheila R. Plant,3 Sovann Kaing,1 Cedric S. Raine,4 David H. Rowitch,1 Robin J. M. Franklin,2{ddagger} Charles D. Stiles1{ddagger}

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

1 Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
2 Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
3 Lineberger Comprehensive Cancer Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
4 Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.



* These authors contributed equally to this work.

{dagger} Present address: Amgen Corporation, 1201 Amgen Court West, Seattle, WA 98119, USA.

{ddagger} To whom correspondence should be addressed. E-mail: charles_stiles{at}dfci.harvard.edu (C.D.S.); rjf1000{at}cam.ac.uk (R.J.M.F.)

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