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This article has been retracted

Science 17 December 2004:
Vol. 306. no. 5704, pp. 2081 - 2084
DOI: 10.1126/science.1103776
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Reports

Darwinian Selection on a Selfing Locus

Kentaro K. Shimizu,1,2 Jennifer M. Cork,1 Ana L. Caicedo,1 Charlotte A. Mays,1 Richard C. Moore,1 Kenneth M. Olsen,1 Stephanie Ruzsa,1 Graham Coop,3* Carlos D. Bustamante,4 Philip Awadalla,1 Michael D. Purugganan1{dagger}

The shift to self-pollination is one of the most prevalent evolutionary transitions in flowering plants. In the selfing plant Arabidopsis thaliana, pseudogenes at the SCR and SRK self-incompatibility loci are believed to underlie the evolution of self-fertilization. Positive directional selection has driven the evolutionary fixation of pseudogene alleles of SCR, leading to substantially reduced nucleotide variation. Coalescent simulations indicate that this adaptive event may have occurred very recently and is possibly associated with the post-Pleistocene expansion of A. thaliana from glacial refugia. This suggests that ancillary morphological innovations associated with self-pollination can evolve rapidly after the inactivation of the self-incompatibility response.

1 Department of Genetics, North Carolina State University, Box 7614, Raleigh, NC 27695, USA.
2 Department of Botany, Graduate School of Science, Kyoto University, Kitashirakawa-oiwake, Sakyo, Kyoto 606–8502, Japan.
3 Department of Statistics, University of Oxford, Oxford, OX1 3TG, UK.
4 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA.



* Present address: Human Genetics Department, University of Chicago, Chicago, IL 60637, USA.

{dagger} To whom correspondence should be addressed. E-mail: michaelp{at}unity.ncsu.edu

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