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Science 17 December 2004:
Vol. 306. no. 5704, pp. 2072 - 2074
DOI: 10.1126/science.1104299
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Reports

Translation of DNA Signals into Polymer Assembly Instructions

Shiping Liao and Nadrian C. Seeman*

We developed a DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device. This machine emulates the translational capabilities of the ribosome. The device has been prototyped to make specific DNA sequences. The state of the device is established by the addition of DNA set strands. There is no transcriptional relationship between the set strands and the product strands. The device has potential applications that include designer polymer synthesis, encryption of information, and use as a variable-input device for DNA-based computation.

Department of Chemistry, New York University, New York, NY 10003, USA.

* To whom correspondence should be addressed. E-mail: ned.seeman{at}nyu.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Noncovalent Immobilization of Streptavidin on In Vitro- and In Vivo-Biotinylated Bacterial Magnetic Particles.
Y. Maeda, T. Yoshino, M. Takahashi, H. Ginya, J. Asahina, H. Tajima, and T. Matsunaga (2008)
Appl. Envir. Microbiol. 74, 5139-5145
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Heat-resistant DNA tile arrays constructed by template-directed photoligation through 5-carboxyvinyl-2'-deoxyuridine.
M. Tagawa, K.-i. Shohda, K. Fujimoto, T. Sugawara, and A. Suyama (2007)
Nucleic Acids Res. 35, e140
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Intravesicular and intervesicular interaction by orthogonal multivalent host guest and metal ligand complexation.
C. W. Lim, O. Crespo-Biel, M. C. A. Stuart, D. N. Reinhoudt, J. Huskens, and B. J. Ravoo (2007)
PNAS 104, 6986-6991
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Operation of a DNA Robot Arm Inserted into a 2D DNA Crystalline Substrate.
B. Ding and N. C. Seeman (2006)
Science 314, 1583-1585
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Science. ISSN 0036-8075 (print), 1095-9203 (online)