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Arkadiusz Chworos,1Isil Severcan,1Alexey Y. Koyfman,1,2Patrick Weinkam,1,4Emin Oroudjev,3Helen G. Hansma,3Luc Jaeger1,2*
One challenge in supramolecular chemistry is the design of versatile,self-assembling building blocks to attain total control of arrangementof matter at a molecular level. We have achieved reliable predictionand design of the three-dimensional structure of artificialRNA building blocks to generate molecular jigsaw puzzle unitscalled tectosquares. They can be programmed with control overtheir geometry, topology, directionality, and addressabilityto algorithmically self-assemble into a variety of complex nanoscopicfabrics with predefined periodic and aperiodic patterns andfinite dimensions. This work emphasizes the modular and hierarchicalcharacteristics of RNA by showing that small RNA structuralmotifs can code the precise topology of large molecular architectures.It demonstrates that fully addressable materials based on RNAcan be synthesized and provides insights into self-assemblyprocesses involving large populations of RNA molecules.
1 Department of Chemistry and Biochemistry, 2 Biomolecular Science and Engineering Program, 3 Department of Physics, University of California, Santa Barbara, CA 93106–9510, USA. 4 Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093, USA.
* To whom correspondence should be addressed. E-mail: jaeger{at}chem.ucsb.edu
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