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Science 26 November 2004:
Vol. 306. no. 5701, pp. 1509 - 1511
DOI: 10.1126/science.1104677
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Jekyll and Hyde in the Microbial World

Dagmar M. Truckses, Lindsay S. Garrenton, Jeremy Thorner*

Fungi are nonmotile organisms that obtain carbon from compounds in their immediate surroundings. Confronted with nutrient limitation, the yeast Saccharomyces cerevisiae undergoes a dimorphic transition, switching from spherical cells to filaments of adherent, elongated cells that can invade the substratum. A complex web of sensing mechanisms and cooperation among signaling networks (including a mitogen-activated protein kinase cascade, cyclic adenosine monophosphate–dependent protein kinase, and 5'–adenosine monophosphate–activated protein kinase) elicits the appropriate changes in physiology, cell cycle progression, cell polarity, and gene expression to achieve this differentiation. Highly related signaling processes control filamentation and virulence of many human fungal pathogens.

Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720–3202, USA.

* To whom correspondence should be addressed. E-mail: jeremy{at}socrates.berkeley.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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The RA Domain of Ste50 Adaptor Protein Is Required for Delivery of Ste11 to the Plasma Membrane in the Filamentous Growth Signaling Pathway of the Yeast Saccharomyces cerevisiae.
D. M. Truckses, J. E. Bloomekatz, and J. Thorner (2006)
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Pheromone Signaling Mechanisms in Yeast: A Prototypical Sex Machine.
Y. Wang and H. G. Dohlman (2004)
Science 306, 1508-1509
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