Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Cambridge Healthtech Institute

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 November 2004:
Vol. 306. no. 5701, pp. 1508 - 1509
DOI: 10.1126/science.1104568
Prev | Table of Contents | Next

Viewpoint

Pheromone Signaling Mechanisms in Yeast: A Prototypical Sex Machine

Yuqi Wang and Henrik G. Dohlman*

The actions of many extracellular stimuli are elicited by complexes of cell surface receptors, heterotrimeric guanine nucleotide–binding proteins (G proteins), and mitogen-activated protein (MAP) kinase complexes. Analysis of haploid yeast cells and their response to peptide mating pheromones has produced important advances in our understanding of G protein and MAP kinase signaling mechanisms. Many of the components, their interrelationships, and their regulators were first identified in yeast. Current analysis of the pheromone response pathway (see the Connections Maps at Science's Signal Transduction Knowledge Environment) will benefit from new and powerful genomic, proteomic, and computational approaches that will likely reveal additional general principles that are applicable to more complex organisms.

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599–7260, USA.

* To whom correspondence should be addressed. E-mail: hdohlman{at}med.unc.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Down-regulation of Pkc1-mediated Signaling by the Deubiquitinating Enzyme Ubp3.
Y. Wang, M. Zhu, M. Ayalew, and J. A. Ruff (2008)
J. Biol. Chem. 283, 1954-1961
   Abstract »    Full Text »    PDF »
Detection of eQTL modules mediated by activity levels of transcription factors.
W. Sun, T. Yu, and K.-C. Li (2007)
Bioinformatics 23, 2290-2297
   Abstract »    Full Text »    PDF »
Mathematical Models of Specificity in Cell Signaling.
L. Bardwell, X. Zou, Q. Nie, and N. L. Komarova (2007)
Biophys. J. 92, 3425-3441
   Abstract »    Full Text »    PDF »
A role for a complex between activated G protein-coupled receptors in yeast cellular mating.
C. Shi, S. Kaminskyj, S. Caldwell, and M. C. Loewen (2007)
PNAS 104, 5395-5400
   Abstract »    Full Text »    PDF »
Regulation of G Protein and Mitogen-Activated Protein Kinase Signaling by Ubiquitination: Insights From Model Organisms.
Y. Wang and H. G. Dohlman (2006)
Circ. Res. 99, 1305-1314
   Abstract »    Full Text »    PDF »
Pheromone Signaling Pathways in Yeast.
H. G. Dohlman and J. E. Slessareva (2006)
Sci. STKE 2006, cm6
   Abstract »    Full Text »    PDF »
G Protein Signaling in Yeast: New Components, New Connections, New Compartments.
J. E. Slessareva and H. G. Dohlman (2006)
Science 314, 1412-1413
   Abstract »    Full Text »    PDF »
Dynamic Studies of Scaffold-Dependent Mating Pathway in Yeast.
D. Shao, W. Zheng, W. Qiu, Q. Ouyang, and C. Tang (2006)
Biophys. J. 91, 3986-4001
   Abstract »    Full Text »    PDF »
Analysis of Mitogen-Activated Protein Kinase Signaling Specificity in Response to Hyperosmotic Stress: Use of an Analog-Sensitive HOG1 Allele..
P. J. Westfall and J. Thorner (2006)
Eukaryot. Cell 5, 1215-1228
   Abstract »    Full Text »    PDF »
Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.
L. S. Garrenton, S. L. Young, and J. Thorner (2006)
Genes & Dev. 20, 1946-1958
   Abstract »    Full Text »    PDF »
Bistability, Stochasticity, and Oscillations in the Mitogen-Activated Protein Kinase Cascade.
X. Wang, N. Hao, H. G. Dohlman, and T. C. Elston (2006)
Biophys. J. 90, 1961-1978
   Abstract »    Full Text »    PDF »
The RA Domain of Ste50 Adaptor Protein Is Required for Delivery of Ste11 to the Plasma Membrane in the Filamentous Growth Signaling Pathway of the Yeast Saccharomyces cerevisiae.
D. M. Truckses, J. E. Bloomekatz, and J. Thorner (2006)
Mol. Cell. Biol. 26, 912-928
   Abstract »    Full Text »    PDF »
Quantitative Phosphoproteomics Applied to the Yeast Pheromone Signaling Pathway.
A. Gruhler, J. V. Olsen, S. Mohammed, P. Mortensen, N. J. Faergeman, M. Mann, and O. N. Jensen (2005)
Mol. Cell. Proteomics 4, 310-327
   Abstract »    Full Text »    PDF »
Jekyll and Hyde in the Microbial World.
D. M. Truckses, L. S. Garrenton, and J. Thorner (2004)
Science 306, 1509-1511
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)