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ReportsProspects for Building the Tree of Life from Large Sequence Databases 
We assess the phylogenetic potential of
1 Section of Evolution and Ecology, University of California, One Shields Avenue, Davis, CA 95616, USA.
* To whom correspondence should be addressed. E-mail: acdriskell{at}ucdavis.edu
The editors suggest the following Related Resources on Science sites:In Science Magazine
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300,000 protein sequences sampled from Swiss-Prot and GenBank. Although only a small subset of these data was potentially phylogenetically informative, this subset retained a substantial fraction of the original taxonomic diversity. Sampling biases in the databases necessitate building phylogenetic data sets that have large numbers of missing entries. However, an analysis of two "supermatrices" suggests that even data sets with as much as 92% missing data can provide insights into broad sections of the tree of life. 
These authors contributed equally to this work. 
Present address: Department of Statistics, University of Wisconsin, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA. 
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