Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Originally published in Science Express on 2 September 2004
Science 8 October 2004:
Vol. 306. no. 5694, p. 241
DOI: 10.1126/science.1102287
Prev | Table of Contents | Next

Brevia

Avian H5N1 Influenza in Cats

Thijs Kuiken,* Guus Rimmelzwaan, Debby van Riel, Geert van Amerongen, Marianne Baars, Ron Fouchier, Albert Osterhaus

During the 2003 to 2004 outbreak of avian influenza A (H5N1) virus in Asia, there were anecdotal reports of fatal infection in domestic cats, although this species is considered resistant to influenza. We experimentally inoculated cats with H5N1 virus intratracheally and by feeding them virus-infected chickens. The cats excreted virus, developed severe diffuse alveolar damage, and transmitted virus to sentinel cats. These results show that domestic cats are at risk of disease or death from H5N1 virus, can be infected by horizontal transmission, and may play a role in the epidemiology of this virus.

Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.

* To whom correspondence should be addressed. E-mail: t.kuiken{at}erasmusmc.nl

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Association of Increased Pathogenicity of Asian H5N1 Highly Pathogenic Avian Influenza Viruses in Chickens with Highly Efficient Viral Replication Accompanied by Early Destruction of Innate Immune Responses.
K. Suzuki, H. Okada, T. Itoh, T. Tada, M. Mase, K. Nakamura, M. Kubo, and K. Tsukamoto (2009)
J. Virol. 83, 7475-7486
   Abstract »    Full Text »    PDF »
Infectious and lethal doses of H5N1 highly pathogenic Avian influenza virus for house sparrows (Passer domesticus) and rock pigeons (Columbia livia).
J. D. Brown, D. E. Stallknecht, R. D. Berghaus, and D. E. Swayne (2009)
J Vet Diagn Invest 21, 437-445
   Abstract »    Full Text »    PDF »
Protection of cats against lethal influenza H5N1 challenge infection.
T. W. Vahlenkamp, T. C. Harder, M. Giese, F. Lin, J. P. Teifke, R. Klopfleisch, R. Hoffmann, I. Tarpey, M. Beer, and T. C. Mettenleiter (2008)
J. Gen. Virol. 89, 968-974
   Abstract »    Full Text »    PDF »
Initial sequence and comparative analysis of the cat genome.
J. U. Pontius, J. C. Mullikin, D. R. Smith, Agencourt Sequencing Team, K. Lindblad-Toh, S. Gnerre, M. Clamp, J. Chang, R. Stephens, B. Neelam, et al. (2007)
Genome Res. 17, 1675-1689
   Abstract »    Full Text »    PDF »
A framework for evaluating animals as sentinels for infectious disease surveillance.
J. E.B Halliday, A. L Meredith, D. L Knobel, D. J Shaw, B. M. d. C Bronsvoort, and S. Cleaveland (2007)
J R Soc Interface 4, 973-984
   Abstract »    Full Text »    PDF »
Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals.
D. van Riel, V. J. Munster, E. de Wit, G. F. Rimmelzwaan, R. A.M. Fouchier, A. D.M.E. Osterhaus, and T. Kuiken (2007)
Am. J. Pathol. 171, 1215-1223
   Abstract »    Full Text »    PDF »
Viral Tropism and the Pathogenesis of Influenza in the Mammalian Host.
K. G. Mansfield (2007)
Am. J. Pathol. 171, 1089-1092
   Full Text »    PDF »
Current Status of Veterinary Vaccines.
E. N. T. Meeusen, J. Walker, A. Peters, P.-P. Pastoret, and G. Jungersen (2007)
Clin. Microbiol. Rev. 20, 489-510
   Abstract »    Full Text »    PDF »
Inefficient Transmission of H5N1 Influenza Viruses in a Ferret Contact Model.
H.-L. Yen, A. S. Lipatov, N. A. Ilyushina, E. A. Govorkova, J. Franks, N. Yilmaz, A. Douglas, A. Hay, S. Krauss, J. E. Rehg, et al. (2007)
J. Virol. 81, 6890-6898
   Abstract »    Full Text »    PDF »
EVOLUTION OF INFLUENZA A VIRUSES IN WILD BIRDS.
R. G. Webster, S. Krauss, D. Hulse-Post, and K. Sturm-Ramirez (2007)
J. Wildl. Dis. 43, S1-S6
   Abstract »    Full Text »    PDF »
Distribution of Lesions and Antigen of Highly Pathogenic Avian Influenza Virus A/Swan/Germany/R65/06 (H5N1) in Domestic Cats after Presumptive Infection by Wild Birds.
R. Klopfleisch, P. U. Wolf, W. Uhl, S. Gerst, T. Harder, E. Starick, T. W. Vahlenkamp, T. C. Mettenleiter, and J. P. Teifke (2007)
Vet. Pathol. 44, 261-268
   Abstract »    Full Text »    PDF »
Avian influenza: A review.
J. K. Thomas and J. Noppenberger (2007)
Am. J. Health Syst. Pharm. 64, 149-165
   Abstract »    Full Text »    PDF »
Key strategies for reducing spread of avian influenza among commercial poultry holdings: lessons for transmission to humans.
A. Le Menach, E. Vergu, R. F Grais, D. L Smith, and A. Flahault (2006)
Proc R Soc B 273, 2467-2475
   Abstract »    Full Text »    PDF »
Avian influenza H5N1 in viverrids: implications for wildlife health and conservation.
S.I Roberton, D.J Bell, G.J.D Smith, J.M Nicholls, K.H Chan, D.T Nguyen, P.Q Tran, U Streicher, L.L.M Poon, H Chen, et al. (2006)
Proc R Soc B 273, 1729-1732
   Abstract »    Full Text »    PDF »
Pathology of Fatal Highly Pathogenic H5N1 Avian Influenza Virus Infection in Large-billed Crows (Corvus macrorhynchos) during the 2004 Outbreak in Japan..
N. Tanimura, K. Tsukamoto, M. Okamatsu, M. Mase, T. Imada, K. Nakamura, M. Kubo, S. Yamaguchi, W. Irishio, M. Hayashi, et al. (2006)
Vet. Pathol. 43, 500-509
   Abstract »    Full Text »    PDF »
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04.
R. Salomon, J. Franks, E. A. Govorkova, N. A. Ilyushina, H.-L. Yen, D. J. Hulse-Post, J. Humberd, M. Trichet, J. E. Rehg, R. J. Webby, et al. (2006)
J. Exp. Med. 203, 689-697
   Abstract »    Full Text »    PDF »
Avian influenza in birds and mammals..
A. A. Cunningham and D. Bell (2006)
Vet Rec. 158, 279
   Full Text »    PDF »
Avian Influenza Virus Infections in Humans.
S. S. Y. Wong and K.-y. Yuen (2006)
Chest 129, 156-168
   Abstract »    Full Text »    PDF »
Influenza A Virus (H5N1) Infection in Cats Causes Systemic Disease with Potential Novel Routes of Virus Spread within and between Hosts.
G. F. Rimmelzwaan, D. van Riel, M. Baars, T. M. Bestebroer, G. van Amerongen, R. A.M. Fouchier, A. D.M.E. Osterhaus, and T. Kuiken (2006)
Am. J. Pathol. 168, 176-183
   Abstract »    Full Text »    PDF »
Avian H5N1 Influenza--Are We Inching Closer to a Global Pandemic?.
P. Sampathkumar and D. G. Maki (2005)
Mayo Clin. Proc. 80, 1552-1555
   PDF »
Immunogenicity of Fowlpox Virus Expressing the Avian Influenza Virus H5 Gene (TROVAC AIV-H5) in Cats.
K. Karaca, D. E. Swayne, D. Grosenbaugh, M. Bublot, A. Robles, E. Spackman, and R. Nordgren (2005)
Clin. Vaccine Immunol. 12, 1340-1342
   Abstract »    Full Text »    PDF »
Avian influenza A (H5N1) infection in humans..
J. H. Beigel (2005)
N. Engl. J. Med. 353, 1374-1385
   Full Text »    PDF »
Avian Influenza (H5N1) Viruses Isolated from Humans in Asia in 2004 Exhibit Increased Virulence in Mammals.
T. R. Maines, X. H. Lu, S. M. Erb, L. Edwards, J. Guarner, P. W. Greer, D. C. Nguyen, K. J. Szretter, L.-M. Chen, P. Thawatsupha, et al. (2005)
J. Virol. 79, 11788-11800
   Abstract »    Full Text »    PDF »
Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines.
E. Hoffmann, A. S. Lipatov, R. J. Webby, E. A. Govorkova, and R. G. Webster (2005)
PNAS 102, 12915-12920
   Abstract »    Full Text »    PDF »
Studies of H5N1 Influenza Virus Infection of Pigs by Using Viruses Isolated in Vietnam and Thailand in 2004.
Y. K. Choi, T. D. Nguyen, H. Ozaki, R. J. Webby, P. Puthavathana, C. Buranathal, A. Chaisingh, P. Auewarakul, N. T. H. Hanh, S. K. Ma, et al. (2005)
J. Virol. 79, 10821-10825
   Abstract »    Full Text »    PDF »
Probable Person-to-Person Transmission of Avian Influenza A (H5N1).
K. Ungchusak, P. Auewarakul, S. F. Dowell, R. Kitphati, W. Auwanit, P. Puthavathana, M. Uiprasertkul, K. Boonnak, C. Pittayawonganon, N. J. Cox, et al. (2005)
N. Engl. J. Med. 352, 333-340
   Abstract »    Full Text »    PDF »
Avian Influenza -- A Challenge to Global Health Care Structures.
T. T. Hien, M. de Jong, and J. Farrar (2004)
N. Engl. J. Med. 351, 2363-2365
   Full Text »    PDF »
Cats Are Susceptible to Avian Influenza.
(2004)
Journal Watch Infectious Diseases 2004, 3
   Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)