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Science 24 September 2004:
Vol. 305. no. 5692, pp. 1972 - 1975
DOI: 10.1126/science.1102026
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Reports

Recycling Endosomes Supply AMPA Receptors for LTP

Mikyoung Park,1* Esther C. Penick,3* Jeffrey G. Edwards,3 Julie A. Kauer,3 Michael D. Ehlers1,2{ddagger}

Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

1 Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
2 Department of Cell Biology, Department of Pharmacology and Cancer Biology, Department of Pathology, and Neuroproteomics Laboratory; Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
3 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.



* These authors contributed equally to this work.

{ddagger} To whom correspondence should be addressed. E-mail: ehlers{at}neuro.duke.edu

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