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Science 17 September 2004:
Vol. 305. no. 5691, pp. 1733 - 1736
DOI: 10.1126/science.1095292
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Review

Living with the Past: Evolution, Development, and Patterns of Disease

Peter D. Gluckman1* and Mark A. Hanson2

Epidemiological observations have led to the hypothesis that the risk of developing some chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult life-style factors but also by environmental factors acting in early life. Research in evolutionary biology, developmental biology, and animal and human physiology provides support for this idea and suggests that environmental processes influencing the propensity to disease in adulthood operate during the periconceptual, fetal, and infant phases of life. This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications.

1 Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2-6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand.
2 Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F (887), Coxford Road, Southampton S016 5YA, UK.

* To whom correspondence should be addressed. E-mail: pd.gluckman{at}auckland.ac.nz

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   Abstract »    Full Text »    PDF »
Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring.
K. A. Lillycrop, E. S. Phillips, A. A. Jackson, M. A. Hanson, and G. C. Burdge (2005)
J. Nutr. 135, 1382-1386
   Abstract »    Full Text »    PDF »
Back to Basics: Attachment, Affect Regulation, and the Developing Right Brain: Linking Developmental Neuroscience to Pediatrics.
A. N. Schore (2005)
Pediatr. Rev. 26, 204-217
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Experimental models of developmental programming: consequences of exposure to an energy rich diet during development.
J. A. Armitage, P. D. Taylor, and L. Poston (2005)
J. Physiol. 565, 3-8
   Abstract »    Full Text »    PDF »
Developmental processes and the induction of cardiovascular function: conceptual aspects.
M. A. Hanson and P. D. Gluckman (2005)
J. Physiol. 565, 27-34
   Abstract »    Full Text »    PDF »
The effects of anaemia as a programming agent in the fetal heart.
L. Davis, K. L. Thornburg, and G. D. Giraud (2005)
J. Physiol. 565, 35-41
   Abstract »    Full Text »    PDF »
Placental angiogenesis in sheep models of compromised pregnancy.
L. P. Reynolds, P. P. Borowicz, K. A. Vonnahme, M. L. Johnson, A. T. Grazul-Bilska, D. A. Redmer, and J. S. Caton (2005)
J. Physiol. 565, 43-58
   Abstract »    Full Text »    PDF »


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