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Science 3 September 2004:
Vol. 305. no. 5689, pp. 1426 - 1431
DOI: 10.1126/science.1102587
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What Can Progeroid Syndromes Tell Us About Human Aging?

David Kipling,1 Terence Davis,1 Elizabeth L. Ostler,2 Richard G. A. Faragher2*

Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.

1 Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2 School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Brighton BN2 4GJ, UK.

* To whom correspondence should be addressed. E-mail: rgaf{at}brighton.ac.uk

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