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Here we present molecular evidence demonstrating that malariaparasites bearing high-level pyrimethamine resistance originallyarrived in Africa from southeast Asia. The resistance allelescarried by these migrants are now spreading across Africa atan alarming rate, signaling the end of affordable malaria treatmentand presenting sub-Saharan Africa with a public health crisis.
1 London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. 2 Southwest Foundation for Biomedical Research, San Antonio, TX, USA. 3 Medical Research Council, Durban, South Africa. 4 Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.
* To whom correspondence should be addressed. E-mail: cally.roper{at}lshtm.ac.uk
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Iruka N. Okeke;, Cally Roper, Richard Pearce, Shalini Nair, Brian Sharp, Richard Pearce, Shalini Nair, Brian Sharp, François Nosten, and Tim Anderson (17 December 2004) Science306 (5704), 2039c.
[DOI: 10.1126/science.306.5704.2039c] |Full Text »|PDF »
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