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Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
Haim Y. Cohen,1Christine Miller,1Kevin J. Bitterman,1Nathan R. Wall,1Brian Hekking,1Benedikt Kessler,1Konrad T. Howitz,2Myriam Gorospe,3Rafael de Cabo,4David A. Sinclair1*
A major cause of aging is thought to result from the cumulativeeffects of cell loss over time. In yeast, caloric restriction(CR) delays aging by activating the Sir2 deacetylase. Here weshow that expression of mammalian Sir2 (SIRT1) is induced inCR rats as well as in human cells that are treated with serumfrom these animals. Insulin and insulin-like growth factor 1(IGF-1) attenuated this response. SIRT1 deacetylates the DNArepair factor Ku70, causing it to sequester the proapoptoticfactor Bax away from mitochondria, thereby inhibiting stress-inducedapoptotic cell death. Thus, CR could extend life-span by inducingSIRT1 expression and promoting the long-term survival of irreplaceablecells.
1 Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. 2 BIOMOL Research Laboratories, 5120 Butler Pike, Plymouth Meeting, PA 19462, USA. 3 Laboratory of Cellular and Molecular Biology, Post Office Box 12, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. 4 Laboratory of Experimental Gerontology, Post Office Box 12, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
* To whom correspondence should be addressed. E-mail: david_sinclair{at}hms.harvard.edu
SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer.
N. Kabra, Z. Li, L. Chen, B. Li, X. Zhang, C. Wang, T. Yeatman, D. Coppola, and J. Chen (2009)
J. Biol. Chem.
284, 18210-18217
|Abstract »|Full Text »|PDF »
Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age.
L. Sun, A. A. Sadighi Akha, R. A. Miller, and J. M. Harper (2009)
J Gerontol A Biol Sci Med Sci
64A, 711-722
|Abstract »|Full Text »|PDF »
Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys.
Z. Q. Wang, Z. E. Floyd, J. Qin, X. Liu, Y. Yu, X. H. Zhang, J. D. Wagner, and W. T. Cefalu (2009)
Diabetes
58, 1488-1498
|Abstract »|Full Text »|PDF »
Regulation of Hypoxia-Inducible Factor 2{alpha} Signaling by the Stress-Responsive Deacetylase Sirtuin 1.
E. M. Dioum, R. Chen, M. S. Alexander, Q. Zhang, R. T. Hogg, R. D. Gerard, and J. A. Garcia (2009)
Science
324, 1289-1293
|Abstract »|Full Text »|PDF »
Protective Role of SIRT1 in Diabetic Vascular Dysfunction.
M. Orimo, T. Minamino, H. Miyauchi, K. Tateno, S. Okada, J. Moriya, and I. Komuro (2009)
Arterioscler. Thromb. Vasc. Biol.
29, 889-894
|Abstract »|Full Text »|PDF »
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation.
K. E. Wellen, G. Hatzivassiliou, U. M. Sachdeva, T. V. Bui, J. R. Cross, and C. B. Thompson (2009)
Science
324, 1076-1080
|Abstract »|Full Text »|PDF »
p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions.
H. Yamaguchi, N. T. Woods, L. G. Piluso, H.-H. Lee, J. Chen, K. N. Bhalla, A. Monteiro, X. Liu, M.-C. Hung, and H.-G. Wang (2009)
J. Biol. Chem.
284, 11171-11183
|Abstract »|Full Text »|PDF »
Inhibition of SUV39H1 Methyltransferase Activity by DBC1.
Z. Li, L. Chen, N. Kabra, C. Wang, J. Fang, and J. Chen (2009)
J. Biol. Chem.
284, 10361-10366
|Abstract »|Full Text »|PDF »
hSirT1-Dependent Regulation of the PCAF-E2F1-p73 Apoptotic Pathway in Response to DNA Damage.
N. Pediconi, F. Guerrieri, S. Vossio, T. Bruno, L. Belloni, V. Schinzari, C. Scisciani, M. Fanciulli, and M. Levrero (2009)
Mol. Cell. Biol.
29, 1989-1998
|Abstract »|Full Text »|PDF »
Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction.
Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice.
J. H. Hwang, D. W. Kim, E. J. Jo, Y. K. Kim, Y. S. Jo, J. H. Park, S. K. Yoo, M. K. Park, T. H. Kwak, Y. L. Kho, et al. (2009)
Diabetes
58, 965-974
|Abstract »|Full Text »|PDF »
SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes.
T. Yoshizaki, J. C. Milne, T. Imamura, S. Schenk, N. Sonoda, J. L. Babendure, J.-C. Lu, J. J. Smith, M. R. Jirousek, and J. M. Olefsky (2009)
Mol. Cell. Biol.
29, 1363-1374
|Abstract »|Full Text »|PDF »
Porcine sirtuin 1 gene clone, expression pattern, and regulation by resveratrol.
T. Shan, Y. Wang, T. Wu, C. Liu, J. Guo, Y. Zhang, J. Liu, and Z. Xu (2009)
J Anim Sci
87, 895-904
|Abstract »|Full Text »|PDF »
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis.
A. Grob, P. Roussel, J. E. Wright, B. McStay, D. Hernandez-Verdun, and V. Sirri (2009)
J. Cell Sci.
122, 489-498
|Abstract »|Full Text »|PDF »
Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.
D. Pons, F. R. de Vries, P. J. van den Elsen, B. T. Heijmans, P. H.A. Quax, and J. W. Jukema (2009)
Eur. Heart J.
30, 266-277
|Abstract »|Full Text »|PDF »
Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification in Escherichia Coli.
J. Zhang, R. Sprung, J. Pei, X. Tan, S. Kim, H. Zhu, C.-F. Liu, N. V. Grishin, and Y. Zhao (2009)
Mol. Cell. Proteomics
8, 215-225
|Abstract »|Full Text »|PDF »
Overexpression of SIRT1 Protects Pancreatic {beta}-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-{kappa}B Signaling Pathway.
J.-H. Lee, M.-Y. Song, E.-K. Song, E.-K. Kim, W. S. Moon, M.-K. Han, J.-W. Park, K.-B. Kwon, and B.-H. Park (2009)
Diabetes
58, 344-351
|Abstract »|Full Text »|PDF »
The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling.
U. Kolthur-Seetharam, K. Teerds, D. G. d. Rooij, O. Wendling, M. McBurney, P. Sassone-Corsi, and I. Davidson (2009)
Biol Reprod
80, 384-391
|Abstract »|Full Text »|PDF »
SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPAR{gamma}.
PCAF Acetylates {beta}-Catenin and Improves Its Stability.
X. Ge, Q. Jin, F. Zhang, T. Yan, and Q. Zhai (2009)
Mol. Biol. Cell
20, 419-427
|Abstract »|Full Text »|PDF »
Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1.
K. Shinmura, K. Tamaki, and R. Bolli (2008)
Am J Physiol Heart Circ Physiol
295, H2348-H2355
|Abstract »|Full Text »|PDF »
Endurance Exercise as a Countermeasure for Aging.
I. R. Lanza, D. K. Short, K. R. Short, S. Raghavakaimal, R. Basu, M. J. Joyner, J. P. McConnell, and K. S. Nair (2008)
Diabetes
57, 2933-2942
|Abstract »|Full Text »|PDF »
SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70.
N. R. Sundaresan, S. A. Samant, V. B. Pillai, S. B. Rajamohan, and M. P. Gupta (2008)
Mol. Cell. Biol.
28, 6384-6401
|Abstract »|Full Text »|PDF »
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis.
S. Greiss, J. Hall, S. Ahmed, and A. Gartner (2008)
Genes & Dev.
22, 2831-2842
|Abstract »|Full Text »|PDF »
Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability.
G. Ramadori, C. E. Lee, A. L. Bookout, S. Lee, K. W. Williams, J. Anderson, J. K. Elmquist, and R. Coppari (2008)
J. Neurosci.
28, 9989-9996
|Abstract »|Full Text »|PDF »
Inflammation and endothelial dysfunction during aging: role of NF-{kappa}B.
A. Csiszar, M. Wang, E. G. Lakatta, and Z. Ungvari (2008)
J Appl Physiol
105, 1333-1341
|Abstract »|Full Text »|PDF »
Resveratrol alleviates alcoholic fatty liver in mice.
J. M. Ajmo, X. Liang, C. Q. Rogers, B. Pennock, and M. You (2008)
Am J Physiol Gastrointest Liver Physiol
295, G833-G842
|Abstract »|Full Text »|PDF »
Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B.
B. Venkatesan, N. Ghosh-Choudhury, F. Das, L. Mahimainathan, A. Kamat, B. S. Kasinath, H. E. Abboud, and G. G. Choudhury (2008)
FASEB J
22, 3469-3482
|Abstract »|Full Text »|PDF »
Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.
S. Dey, V. Bakthavatchalu, M. T. Tseng, P. Wu, R. L. Florence, E. A. Grulke, R. A. Yokel, S. K. Dhar, H.-S. Yang, Y. Chen, et al. (2008)
Carcinogenesis
29, 1920-1929
|Abstract »|Full Text »|PDF »
SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism.
X.-J. Liang, T. Finkel, D.-W. Shen, J.-J. Yin, A. Aszalos, and M. M. Gottesman (2008)
Mol. Cancer Res.
6, 1499-1506
|Abstract »|Full Text »|PDF »
Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons.
SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells.
R. Miyazaki, T. Ichiki, T. Hashimoto, K. Inanaga, I. Imayama, J. Sadoshima, and K. Sunagawa (2008)
Arterioscler. Thromb. Vasc. Biol.
28, 1263-1269
|Abstract »|Full Text »|PDF »
Tissue-specific regulation of SIRT1 by calorie restriction.
D. Chen, J. Bruno, E. Easlon, S.-J. Lin, H.-L. Cheng, F. W. Alt, and L. Guarente (2008)
Genes & Dev.
22, 1753-1757
|Abstract »|Full Text »|PDF »
Isoflavones Promote Mitochondrial Biogenesis.
K. A. Rasbach and R. G. Schnellmann (2008)
J. Pharmacol. Exp. Ther.
325, 536-543
|Abstract »|Full Text »|PDF »
Effect of exercise and calorie restriction on biomarkers of aging in mice.
D. M. Huffman, D. R. Moellering, W. E. Grizzle, C. R. Stockard, M. S. Johnson, and T. R. Nagy (2008)
Am J Physiol Regulatory Integrative Comp Physiol
294, R1618-R1627
|Abstract »|Full Text »|PDF »
Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation.
A. D. Amsel, M. Rathaus, N. Kronman, and H. Y. Cohen (2008)
PNAS
105, 5117-5122
|Abstract »|Full Text »|PDF »
Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation.
K. Li, A. Casta, R. Wang, E. Lozada, W. Fan, S. Kane, Q. Ge, W. Gu, D. Orren, and J. Luo (2008)
J. Biol. Chem.
283, 7590-7598
|Abstract »|Full Text »|PDF »
Mechanisms Underlying Caloric Restriction and Lifespan Regulation: Implications for Vascular Aging.
Z. Ungvari, C. Parrado-Fernandez, A. Csiszar, and R. de Cabo (2008)
Circ. Res.
102, 519-528
|Abstract »|Full Text »|PDF »
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
I. H. Lee, L. Cao, R. Mostoslavsky, D. B. Lombard, J. Liu, N. E. Bruns, M. Tsokos, F. W. Alt, and T. Finkel (2008)
PNAS
105, 3374-3379
|Abstract »|Full Text »|PDF »
Cells From Long-Lived Mutant Mice Exhibit Enhanced Repair of Ultraviolet Lesions.
A. B. Salmon, M. Ljungman, and R. A. Miller (2008)
J. Gerontol. A Biol. Sci. Med. Sci.
63, 219-231
|Abstract »|Full Text »|PDF »
SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity.
S. R. Narala, R. C. Allsopp, T. B. Wells, G. Zhang, P. Prasad, M. J. Coussens, D. J. Rossi, I. L. Weissman, and H. Vaziri (2008)
Mol. Biol. Cell
19, 1210-1219
|Abstract »|Full Text »|PDF »
Acetylation-dependent ADP-ribosylation by Trypanosoma brucei Sir2.
T. M. Kowieski, S. Lee, and J. M. Denu (2008)
J. Biol. Chem.
283, 5317-5326
|Abstract »|Full Text »|PDF »
Role of Mitochondrial Dysfunction in Insulin Resistance.
I. Mattagajasingh, C.-S. Kim, A. Naqvi, T. Yamamori, T. A. Hoffman, S.-B. Jung, J. DeRicco, K. Kasuno, and K. Irani (2007)
PNAS
104, 14855-14860
|Abstract »|Full Text »|PDF »
SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study.
M. Kuningas, M. Putters, R. G. J. Westendorp, P. E. Slagboom, and D. van Heemst (2007)
J. Gerontol. A Biol. Sci. Med. Sci.
62, 960-965
|Abstract »|Full Text »|PDF »
SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer.
D. M. Huffman, W. E. Grizzle, M. M. Bamman, J.-s. Kim, I. A. Eltoum, A. Elgavish, and T. R. Nagy (2007)
Cancer Res.
67, 6612-6618
|Abstract »|Full Text »|PDF »
Histone Deacetylase Inhibitors Sensitize Prostate Cancer Cells to Agents that Produce DNA Double-Strand Breaks by Targeting Ku70 Acetylation.
C.-S. Chen, Y.-C. Wang, H.-C. Yang, P.-H. Huang, S. K. Kulp, C.-C. Yang, Y.-S. Lu, S. Matsuyama, C.-Y. Chen, and C.-S. Chen (2007)
Cancer Res.
67, 5318-5327
|Abstract »|Full Text »|PDF »
Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart.
R. R. Alcendor, S. Gao, P. Zhai, D. Zablocki, E. Holle, X. Yu, B. Tian, T. Wagner, S. F. Vatner, and J. Sadoshima (2007)
Circ. Res.
100, 1512-1521
|Abstract »|Full Text »|PDF »
The Effect of {beta}-Adrenergic and Peroxisome Proliferator-Activated Receptor-{gamma} Stimulation on Target Genes Related to Lipid Metabolism in Human Subcutaneous Adipose Tissue.
I. Bogacka, T. W. Gettys, L. de Jonge, T. Nguyen, J. M. Smith, H. Xie, F. Greenway, and S. R. Smith (2007)
Diabetes Care
30, 1179-1186
|Abstract »|Full Text »|PDF »
Different Gene Expression of Skin Tissues Between Mice with Weight Controlled by Either Calorie Restriction or Physical Exercise.
J. Lu, L. Xie, J. Sylvester, J. Wang, J. Bai, R. Baybutt, and W. Wang (2007)
Experimental Biology and Medicine
232, 473-480
|Abstract »|Full Text »|PDF »
High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO.
B. Gershman, O. Puig, L. Hang, R. M. Peitzsch, M. Tatar, and R. S. Garofalo (2007)
Physiol Genomics
29, 24-34
|Abstract »|Full Text »|PDF »
Sirtuin 2, a Mammalian Homolog of Yeast Silent Information Regulator-2 Longevity Regulator, Is an Oligodendroglial Protein That Decelerates Cell Differentiation through Deacetylating {alpha}-Tubulin.
W. Li, B. Zhang, J. Tang, Q. Cao, Y. Wu, C. Wu, J. Guo, E.-A. Ling, and F. Liang (2007)
J. Neurosci.
27, 2606-2616
|Abstract »|Full Text »|PDF »
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1.
M. Tanno, J. Sakamoto, T. Miura, K. Shimamoto, and Y. Horio (2007)
J. Biol. Chem.
282, 6823-6832
|Abstract »|Full Text »|PDF »
The mitochondrial energy transduction system and the aging process.
Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.
Q. Zhang, S.-Y. Wang, C. Fleuriel, D. Leprince, J. V. Rocheleau, D. W. Piston, and R. H. Goodman (2007)
PNAS
104, 829-833
|Abstract »|Full Text »|PDF »
SIRT1 Inhibits Transforming Growth Factor beta-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation.
S. Kume, M. Haneda, K. Kanasaki, T. Sugimoto, S.-i. Araki, K. Isshiki, M. Isono, T. Uzu, L. Guarente, A. Kashiwagi, et al. (2007)
J. Biol. Chem.
282, 151-158
|Abstract »|Full Text »|PDF »
Sirtuins in Aging and Disease.
L. Guarente (2007)
Cold Spring Harb Symp Quant Biol
72, 483-488
|Abstract »|PDF »
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction..
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy.
J. B. Pillai, M. Gupta, S. B. Rajamohan, R. Lang, J. Raman, and M. P. Gupta (2006)
Am J Physiol Heart Circ Physiol
291, H1545-H1553
|Abstract »|Full Text »|PDF »
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?.
P. O. Hassa, S. S. Haenni, M. Elser, and M. O. Hottiger (2006)
Microbiol. Mol. Biol. Rev.
70, 789-829
|Abstract »|Full Text »|PDF »
Histone H2A.z Is Essential for Cardiac Myocyte Hypertrophy but Opposed by Silent Information Regulator 2{alpha}.
I.-Y. Chen, J. Lypowy, J. Pain, D. Sayed, S. Grinberg, R. R. Alcendor, J. Sadoshima, and M. Abdellatif (2006)
J. Biol. Chem.
281, 19369-19377
|Abstract »|Full Text »|PDF »
Metabolite of SIR2 Reaction Modulates TRPM2 Ion Channel.
O. Grubisha, L. A. Rafty, C. L. Takanishi, X. Xu, L. Tong, A.-L. Perraud, A. M. Scharenberg, and J. M. Denu (2006)
J. Biol. Chem.
281, 14057-14065
|Abstract »|Full Text »|PDF »
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes..
B. Heltweg, T. Gatbonton, A. D. Schuler, J. Posakony, H. Li, S. Goehle, R. Kollipara, R. A. DePinho, Y. Gu, J. A. Simon, et al. (2006)
Cancer Res.
66, 4368-4377
|Abstract »|Full Text »|PDF »
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency.
G. López-Lluch, N. Hunt, B. Jones, M. Zhu, H. Jamieson, S. Hilmer, M. V. Cascajo, J. Allard, D. K. Ingram, P. Navas, et al. (2006)
PNAS
103, 1768-1773
|Abstract »|Full Text »|PDF »
MCH-/- Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance.
J. Y. Jeon, R. L. Bradley, E. G. Kokkotou, F. E. Marino, X. Wang, P. Pissios, and E. Maratos-Flier (2006)
Diabetes
55, 428-434
|Abstract »|Full Text »|PDF »
Nuclear-Mitochondrial Epistasis and Drosophila Aging: Introgression of Drosophila simulans mtDNA Modifies Longevity in D. melanogaster Nuclear Backgrounds.
Poly(ADP-ribose) Polymerase-1-dependent Cardiac Myocyte Cell Death during Heart Failure Is Mediated by NAD+ Depletion and Reduced Sir2{alpha} Deacetylase Activity.
J. B. Pillai, A. Isbatan, S.-i. Imai, and M. P. Gupta (2005)
J. Biol. Chem.
280, 43121-43130
|Abstract »|Full Text »|PDF »
Ecto-ADP-ribose Transferases: Cell-Surface Response to Local Tissue Injury.
Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS.
E. Nisoli, C. Tonello, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, E. Clementi, et al. (2005)
Science
310, 314-317
|Abstract »|Full Text »|PDF »
Diabesity: A Polygenic Model of Dietary-Induced Obesity from Ad Libitum Overfeeding of Sprague-Dawley Rats and Its Modulation by Moderate and Marked Dietary Restriction.
K. P. Keenan, C.-M. Hoe, L. Mixson, C. L. Mccoy, J. B. Coleman, B. A. Mattson, G. A. Ballam, L. A. Gumprecht, and K. A. Soper (2005)
Toxicol Pathol
33, 650-674
|Abstract »|Full Text »|PDF »
Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins.
E. Michishita, J. Y. Park, J. M. Burneskis, J. C. Barrett, and I. Horikawa (2005)
Mol. Biol. Cell
16, 4623-4635
|Abstract »|Full Text »|PDF »
Gene expression profiling reveals a signaling role of glutathione in redox regulation.
M. Fratelli, L. O. Goodwin, U. A. Orom, S. Lombardi, R. Tonelli, M. Mengozzi, and P. Ghezzi (2005)
PNAS
102, 13998-14003
|Abstract »|Full Text »|PDF »
Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria.
L. Bevilacqua, J. J. Ramsey, K. Hagopian, R. Weindruch, and M.-E. Harper (2005)
Am J Physiol Endocrinol Metab
289, E429-E438
|Abstract »|Full Text »|PDF »
2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on Mammary Carcinogenesis and on Mammary Tumor Cell Growth In vitro.
Z. Zhu, W. Jiang, J. N. McGinley, and H. J. Thompson (2005)
Cancer Res.
65, 7023-7030
|Abstract »|Full Text »|PDF »
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging.
G. C. Kujoth, A. Hiona, T. D. Pugh, S. Someya, K. Panzer, S. E. Wohlgemuth, T. Hofer, A. Y. Seo, R. Sullivan, W. A. Jobling, et al. (2005)
Science
309, 481-484
|Abstract »|Full Text »|PDF »
Differential Regulation of Amino Acid Transporter SNAT3 by Insulin in Hepatocytes.
S. Gu, C. J. Villegas, and J. X. Jiang (2005)
J. Biol. Chem.
280, 26055-26062
|Abstract »|Full Text »|PDF »
Pre-B-Cell Colony-Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation.
E. van der Veer, Z. Nong, C. O'Neil, B. Urquhart, D. Freeman, and J. G. Pickering (2005)
Circ. Res.
97, 25-34
|Abstract »|Full Text »|PDF »
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1{alpha}.
S. Nemoto, M. M. Fergusson, and T. Finkel (2005)
J. Biol. Chem.
280, 16456-16460
|Abstract »|Full Text »|PDF »
SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes.
T. Shi, F. Wang, E. Stieren, and Q. Tong (2005)
J. Biol. Chem.
280, 13560-13567
|Abstract »|Full Text »|PDF »
Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells.
N. Matsushita, Y. Takami, M. Kimura, S. Tachiiri, M. Ishiai, T. Nakayama, and M. Takata (2005)
Genes Cells
10, 321-332
|Abstract »|Full Text »|PDF »
Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors.
C. Subramanian, A. W. Opipari Jr., X. Bian, V. P. Castle, and R. P. S. Kwok (2005)
PNAS
102, 4842-4847
|Abstract »|Full Text »|PDF »
SIRT1 Shows No Substrate Specificity in Vitro.
G. Blander, J. Olejnik, E. Krzymanska-Olejnik, T. McDonagh, M. Haigis, M. B. Yaffe, and L. Guarente (2005)
J. Biol. Chem.
280, 9780-9785
|Abstract »|Full Text »|PDF »
Histone acetylation and deacetylation: importance in inflammatory lung diseases.
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells.
J. R. Revollo, A. A. Grimm, and S.-i. Imai (2004)
J. Biol. Chem.
279, 50754-50763
|Abstract »|Full Text »|PDF »
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice.
V. K. Yechoor, M.-E. Patti, K. Ueki, P. G. Laustsen, R. Saccone, R. Rauniyar, and C. R. Kahn (2004)
PNAS
101, 16525-16530
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Sirviving Cardiac Stress: Cardioprotection Mediated by a Longevity Gene.
