Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 July 2004:
Vol. 305. no. 5681, pp. 258 - 262
DOI: 10.1126/science.1097938
Prev | Table of Contents | Next

Reports

Cognitive Control Signals for Neural Prosthetics

S. Musallam, B. D. Corneil,* B. Greger, H. Scherberger,{dagger} R. A. Andersen{ddagger}

Recent development of neural prosthetics for assisting paralyzed patients has focused on decoding intended hand trajectories from motor cortical neurons and using this signal to control external devices. In this study, higher level signals related to the goals of movements were decoded from three monkeys and used to position cursors on a computer screen without the animals emitting any behavior. Their performance in this task improved over a period of weeks. Expected value signals related to fluid preference, the expected magnitude, or probability of reward were decoded simultaneously with the intended goal. For neural prosthetic applications, the goal signals can be used to operate computers, robots, and vehicles, whereas the expected value signals can be used to continuously monitor a paralyzed patient's preferences and motivation.

Division of Biology, California Institute of Technology, Mail Code 216-76, Pasadena, CA 91125, USA.



* Present address: Department of Physiology, Pharmacology, and Psychology, University of Western Ontario, London, ON N6A 5K8, Canada.

{dagger} Present address: Institute of Neuroinformatics, University/Eidgenössische Technische Hochschule (ETH) Zurich, 8057 Zurich, Switzerland.

{ddagger} To whom correspondence should be addressed. E-mail: andersen{at}vis.caltech.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Explicit neural signals reflecting reward uncertainty.
W. Schultz, K. Preuschoff, C. Camerer, M. Hsu, C. D Fiorillo, P. N Tobler, and P. Bossaerts (2008)
Phil Trans R Soc B 363, 3801-3811
   Abstract »    Full Text »    PDF »
Functional network reorganization during learning in a brain-computer interface paradigm.
B. Jarosiewicz, S. M. Chase, G. W. Fraser, M. Velliste, R. E. Kass, and A. B. Schwartz (2008)
PNAS 105, 19486-19491
   Abstract »    Full Text »    PDF »
Toward Optimal Target Placement for Neural Prosthetic Devices.
J. P. Cunningham, B. M. Yu, V. Gilja, S. I. Ryu, and K. V. Shenoy (2008)
J Neurophysiol 100, 3445-3457
   Abstract »    Full Text »    PDF »
Decoding Trajectories from Posterior Parietal Cortex Ensembles.
G. H. Mulliken, S. Musallam, and R. A. Andersen (2008)
J. Neurosci. 28, 12913-12926
   Abstract »    Full Text »    PDF »
Advanced Neurotechnologies for Chronic Neural Interfaces: New Horizons and Clinical Opportunities.
D. R. Kipke, W. Shain, G. Buzsaki, E. Fetz, J. M. Henderson, J. F. Hetke, and G. Schalk (2008)
J. Neurosci. 28, 11830-11838
   Full Text »    PDF »
Selectivity for Grasp in Local Field Potential and Single Neuron Activity Recorded Simultaneously from M1 and F5 in the Awake Macaque Monkey.
R. L. Spinks, A. Kraskov, T. Brochier, M. A. Umilta, and R. N. Lemon (2008)
J. Neurosci. 28, 10961-10971
   Abstract »    Full Text »    PDF »
Detecting Neural-State Transitions Using Hidden Markov Models for Motor Cortical Prostheses.
C. Kemere, G. Santhanam, B. M. Yu, A. Afshar, S. I. Ryu, T. H. Meng, and K. V. Shenoy (2008)
J Neurophysiol 100, 2441-2452
   Abstract »    Full Text »    PDF »
Probability-Based Prediction of Activity in Multiple Arm Muscles: Implications for Functional Electrical Stimulation.
C. V. Anderson and A. J. Fuglevand (2008)
J Neurophysiol 100, 482-494
   Abstract »    Full Text »    PDF »
Decoding of Temporal Intervals From Cortical Ensemble Activity.
M. A. Lebedev, J. E. O'Doherty, and M. A. L. Nicolelis (2008)
J Neurophysiol 99, 166-186
   Abstract »    Full Text »    PDF »
Single-Neuron Stability during Repeated Reaching in Macaque Premotor Cortex.
C. A. Chestek, A. P. Batista, G. Santhanam, B. M. Yu, A. Afshar, J. P. Cunningham, V. Gilja, S. I. Ryu, M. M. Churchland, and K. V. Shenoy (2007)
J. Neurosci. 27, 10742-10750
   Abstract »    Full Text »    PDF »
General-Purpose Filter Design for Neural Prosthetic Devices.
L. Srinivasan, U. T. Eden, S. K. Mitter, and E. N. Brown (2007)
J Neurophysiol 98, 2456-2475
   Abstract »    Full Text »    PDF »
Decoding Visual Inputs From Multiple Neurons in the Human Temporal Lobe.
R. Q. Quiroga, L. Reddy, C. Koch, and I. Fried (2007)
J Neurophysiol 98, 1997-2007
   Abstract »    Full Text »    PDF »
Human Parietal "Reach Region" Primarily Encodes Intrinsic Visual Direction, Not Extrinsic Movement Direction, in a Visual Motor Dissociation Task.
J. Fernandez-Ruiz, H. C. Goltz, J. F. X. DeSouza, T. Vilis, and J. D. Crawford (2007)
Cereb Cortex 17, 2283-2292
   Abstract »    Full Text »    PDF »
Predicting Movement from Multiunit Activity.
E. Stark and M. Abeles (2007)
J. Neurosci. 27, 8387-8394
   Abstract »    Full Text »    PDF »
Direct Instrumental Conditioning of Neural Activity Using Functional Magnetic Resonance Imaging-Derived Reward Feedback.
S. Bray, S. Shimojo, and J. P. O'Doherty (2007)
J. Neurosci. 27, 7498-7507
   Abstract »    Full Text »    PDF »
Mixture of Trajectory Models for Neural Decoding of Goal-Directed Movements.
B. M. Yu, C. Kemere, G. Santhanam, A. Afshar, S. I. Ryu, T. H. Meng, M. Sahani, and K. V. Shenoy (2007)
J Neurophysiol 97, 3763-3780
   Abstract »    Full Text »    PDF »
Volitional control of neural activity: implications for brain-computer interfaces.
E. E. Fetz (2007)
J. Physiol. 579, 571-579
   Abstract »    Full Text »    PDF »
Brain-computer interfaces as new brain output pathways.
J. R. Wolpaw (2007)
J. Physiol. 579, 613-619
   Abstract »    Full Text »    PDF »
Target Selection Signals for Arm Reaching in the Posterior Parietal Cortex.
H. Scherberger and R. A. Andersen (2007)
J. Neurosci. 27, 2001-2012
   Abstract »    Full Text »    PDF »
Preparatory Activity in Premotor and Motor Cortex Reflects the Speed of the Upcoming Reach.
M. M. Churchland, G. Santhanam, and K. V. Shenoy (2006)
J Neurophysiol 96, 3130-3146
   Abstract »    Full Text »    PDF »
Effects of Noise Correlations on Information Encoding and Decoding.
B. B. Averbeck and D. Lee (2006)
J Neurophysiol 95, 3633-3644
   Abstract »    Full Text »    PDF »
Stable Ensemble Performance with Single-Neuron Variability during Reaching Movements in Primates.
J. M. Carmena, M. A. Lebedev, C. S. Henriquez, and M. A. L. Nicolelis (2005)
J. Neurosci. 25, 10712-10716
   Abstract »    Full Text »    PDF »
Motor Cortex Neural Correlates of Output Kinematics and Kinetics During Isometric-Force and Arm-Reaching Tasks.
L. E. Sergio, C. Hamel-Paquet, and J. F. Kalaska (2005)
J Neurophysiol 94, 2353-2378
   Abstract »    Full Text »    PDF »
Supplementary Motor Area Encodes Reward Expectancy in Eye-Movement Tasks.
M. Campos, B. Breznen, K. Bernheim, and R. A. Andersen (2005)
J Neurophysiol 94, 1325-1335
   Abstract »    Full Text »    PDF »
Cortical Ensemble Adaptation to Represent Velocity of an Artificial Actuator Controlled by a Brain-Machine Interface.
M. A. Lebedev, J. M. Carmena, J. E. O'Doherty, M. Zacksenhouse, C. S. Henriquez, J. C. Principe, and M. A. L. Nicolelis (2005)
J. Neurosci. 25, 4681-4693
   Abstract »    Full Text »    PDF »
Doctoral Preparation of Scientifically Based Education Researchers.
M. Eisenhart and R. L. DeHaan (2005)
Educational Researcher 34, 3-13
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)