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Science 2 July 2004:
Vol. 305. no. 5680, pp. 96 - 99
DOI: 10.1126/science.1098180
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Reports

Sites of Neocortical Reorganization Critical for Remote Spatial Memory

Thibault Maviel, Thomas P. Durkin, Frédérique Menzaghi, Bruno Bontempi*

The hippocampus is crucial for spatial memory formation, yet it does not store long-lasting memories. By combining functional brain imaging and region-specific neuronal inactivation in mice, we identified prefrontal and anterior cingulate cortex as critical for storage and retrieval of remote spatial memories. Imaging of activity-dependent genes also revealed an involvement of parietal and retrosplenial cortices during consolidation of remote memory. Long-term memory storage within some of these neocortical regions was accompanied by structural changes including synaptogenesis and laminar reorganization, concomitant with a functional disengagement of the hippocampus and posterior cingulate cortices. Thus, consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently.

Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Université de Bordeaux 1, Avenue des Facultés, 33405 Talence, France.

* To whom correspondence should be addressed. E-mail: b.bontempi{at}lnc.u-bordeaux1.fr

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