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Originally published in Science Express on 1 April 2004
Science 28 May 2004:
Vol. 304. no. 5675, pp. 1338 - 1340
DOI: 10.1126/science.1095505
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Reports

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

Qin Shen,1 Susan K. Goderie,1 Li Jin,1 Nithin Karanth,1 Yu Sun,1 Natalia Abramova,1 Peter Vincent,2 Kevin Pumiglia,3 Sally Temple1*

Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.

1 Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA.
2 Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA.
3 Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA.

* To whom correspondence should be addressed. E-mail: TempleS{at}mail.amc.edu

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T. Nagase, M. Nagase, K. Yoshimura, T. Fujita, and I. Koshima (2005)
Genes Cells 10, 595-604
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Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells.
A. Kortesidis, A. Zannettino, S. Isenmann, S. Shi, T. Lapidot, and S. Gronthos (2005)
Blood 105, 3793-3801
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Nestin-Immunoreactive Cells in Rat Pituitary Are neither Hormonal nor Typical Folliculo-Stellate Cells.
O. Krylyshkina, J. Chen, L. Mebis, C. Denef, and H. Vankelecom (2005)
Endocrinology 146, 2376-2387
   Abstract »    Full Text »    PDF »
Essential Role of Endothelial Notch1 in Angiogenesis.
F. P. Limbourg, K. Takeshita, F. Radtke, R. T. Bronson, M. T. Chin, and J. K. Liao (2005)
Circulation 111, 1826-1832
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The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment.
J. E. Trosko and B. L. Upham (2005)
Mutagenesis 20, 81-92
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Signaling in stem cell niches: lessons from the Drosophila germline.
Y. M. Yamashita, M. T. Fuller, and D. L. Jones (2005)
J. Cell Sci. 118, 665-672
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Signals Regulating Neurogenesis in the Adult Olfactory Bulb.
H. G. Kuhn, C. Cooper-Kuhn, P. Eriksson, and M. Nilsson (2005)
Chem Senses 30, i109-i110
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