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Science 14 May 2004:
Vol. 304. no. 5673, pp. 1024 - 1027
DOI: 10.1126/science.1094932
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Reports

Exclusive Consolidated Memory Phases in Drosophila

Guillaume Isabel,* Alberto Pascual,*{dagger} Thomas Preat{ddagger}

Two types of consolidated memory have been described in Drosophila, anesthesia-resistant memory (ARM), a shorter-lived form, and stabilized long-term memory (LTM). Until now, it has been thought that ARM and LTM coexist. On the contrary, we show that LTM formation leads to the extinction of ARM. Flies devoid of mushroom body vertical lobes cannot form LTM, but spaced conditioning can still erase their ARM, resulting in a remarkable situation: The more these flies are trained, the less they remember. We propose that ARM acts as a gating mechanism that ensures that LTM is formed only after repetitive and spaced training.

Développement, Evolution, Plasticité du Système Nerveux, CNRS, 1 Avenue de la Terrasse, 91190 Gifsur-Yvette, France.



* These authors contributed equally to this work.

{dagger} Present address: Laboratorio de Investigaciones Biomédicas, Hospitales Universitarios Virgen del Rocío, Avenida Manuel Siurot (s/n, no number), Edificio de Laboratorios, Planta 2, 41013 Sevilla, Spain.

{ddagger} To whom correspondence should be addressed. E-mail: preat{at}iaf.cnrs-gif.fr.

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