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Science 9 April 2004:
Vol. 304. no. 5668, pp. 242 - 248
DOI: 10.1126/science.1090124
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Review

Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens

Pascale Cossart1* and Philippe J. Sansonetti2*

Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate from cell to cell by means of an actin-based motility process. The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection.

1 Unité des Interactions Bactéries-Cellules, INSERM Unité 604, Département de Biologie Cellulaire et Infection, Institut Pasteur, 28 Rue du Docteur Roux, Paris 75015, France.
2 Unité de Pathogénie Microbienne Moleculaire, INSERM Unité 389, Département de Biologie Cellulaire et Infection, Institut Pasteur, 28 Rue du Docteur Roux, Paris 75015, France.

* To whom correspondence should be addressed. E-mail: pcossart{at}pasteur.fr (P.C.); psan.son{at}pasteur.fr (P.J.S.)

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