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Science 9 April 2004:
Vol. 304. no. 5668, pp. 237 - 242
DOI: 10.1126/science.1094823

Review

How Viruses Enter Animal Cells

Alicia E. Smith and Ari Helenius*

Viruses replicate within living cells and use the cellular machinery for the synthesis of their genome and other components. To gain access, they have evolved a variety of elegant mechanisms to deliver their genes and accessory proteins into the host cell. Many animal viruses take advantage of endocytic pathways and rely on the cell to guide them through a complex entry and uncoating program. In the dialogue between the cell and the intruder, the cell provides critical cues that allow the virus to undergo molecular transformations that lead to successful internalization, intra-cellular transport, and uncoating.

Institute of Biochemistry, Swiss Federal Institute of Technology–Zurich, CH-8093 Zurich, Switzerland.

* To whom correspondence should be addressed. E-mail: ari.helenius{at}bc.biol.ethz.ch

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Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus.
L. Guillot, R. Le Goffic, S. Bloch, N. Escriou, S. Akira, M. Chignard, and M. Si-Tahar (2005)
J. Biol. Chem. 280, 5571-5580
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Enhanced Cytotoxicity without Internuclear Spread of Adenovirus upon Cell Fusion by Measles Virus Glycoproteins.
G. P. Horn, S. Vongpunsawad, E. Kornmann, B. Fritz, D. P. Dittmer, R. Cattaneo, and M. Dobbelstein (2005)
J. Virol. 79, 1911-1917
   Abstract »    Full Text »    PDF »
Sperm-egg fusion: events at the plasma membrane.
K. K. Stein, P. Primakoff, and D. Myles (2004)
J. Cell Sci. 117, 6269-6274
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CXCR4-Tropic HIV-1 Envelope Glycoprotein Functions as a Viral Chemokine in Unstimulated Primary CD4+ T Lymphocytes.
K. Balabanian, J. Harriague, C. Decrion, B. Lagane, S. Shorte, F. Baleux, J.-L. Virelizier, F. Arenzana-Seisdedos, and L. A. Chakrabarti (2004)
J. Immunol. 173, 7150-7160
   Abstract »    Full Text »    PDF »
Video Views and Reviews: Creating a Thread with Respect to the Invasion of Animal Viruses.
C. Watters (2004)
CBE Life Sci Educ 3, 218-222
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