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Science 26 March 2004:
Vol. 303. no. 5666, pp. 2019 - 2022
DOI: 10.1126/science.1093137
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Reports

Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

Cynthia A. Derdeyn,1,7 Julie M. Decker,3 Frederic Bibollet-Ruche,2,7 John L. Mokili,4 Mark Muldoon,5 Scott A. Denham,1 Marintha L. Heil,1 Francis Kasolo,8 Rosemary Musonda,9 Beatrice H. Hahn,1,2,7 George M. Shaw,1,2,3,7 Bette T. Korber,4,10 Susan Allen,6,7 Eric Hunter1,7*

Heterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

1 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
2 Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
3 Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
4 HIV Sequence Database, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
5 Department of Mathematics, University of Manchester Institute of Science and Technology, Manchester, UK.
6 Department of Epidemiology and International Health, School of Public Health; University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7 University of Alabama at Birmingham Center for AIDS Research; University of Alabama at Birmingham, Birmingham, AL 35294, USA.
8 Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia.
9 Tropical Disease Research Center, Ndola, Zambia.
10 Santa Fe Institute, Santa Fe, NM 87501, USA.

* To whom correspondence should be addressed. E-mail: ehunter{at}uab.edu

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