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Science 19 March 2004:
Vol. 303. no. 5665, pp. 1818 - 1822
DOI: 10.1126/science.1095833
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Drug Delivery Systems: Entering the Mainstream

Theresa M. Allen1* and Pieter R. Cullis2,3

Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.

1 Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada.
2 Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada.
3 Inex Pharmaceuticals Corporation, Burnaby, British Columbia V5J 5J8, Canada.

* To whom correspondence should be addressed. E-mail: terry.allen{at}ualberta.ca

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