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Science 12 March 2004:
Vol. 303. no. 5664, pp. 1626 - 1632
DOI: 10.1126/science.1089670
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Review

Mobile Elements: Drivers of Genome Evolution

Haig H. Kazazian, Jr.*

Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to constitute a large fraction of the genome and have shaped both genes and the entire genome. Although the host can often control their numbers, massive expansions of retrotransposons have been tolerated during evolution. Now mobile elements are becoming useful tools for learning more about genome evolution and gene function.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

* E-mail: kazazian{at}mail.med.upenn.edu

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