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Science 5 March 2004:
Vol. 303. no. 5663, pp. 1512 - 1514
DOI: 10.1126/science.1092550
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Reports

Ethanol Augments GABAergic Transmission in the Central Amygdala via CRF1 Receptors

Zhiguo Nie,1 Paul Schweitzer,1 Amanda J. Roberts,1 Samuel G. Madamba,1 Scott D. Moore,2 George Robert Siggins1*

The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced {gamma}-aminobutyric acid–mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects.

1 Department of Neuropharmacology and Alcohol Research Center, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
2 Department of Psychiatry, Duke University, Durham, NC 27710, USA.

* To whom correspondence should be addressed. E-mail: geobob{at}scripps.edu

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