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Science 5 March 2004: Vol. 303. no. 5663, pp. 1483 - 1487 DOI: 10.1126/science.1094291
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Review
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
W. James Nelson1* and
Roel Nusse2,3
The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, ß-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, ß-catenin functions, and cadherin-mediated adhesion.
1 Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
3 Department of Developmental Biology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
* To whom correspondence should be addressed. E-mail: wjnelson{at}stanford.edu
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- J.-S. Park, M. T. Valerius, and A. P. McMahon (2007)
Development
134, 2533-2539
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- Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.
- Y. Su, F. A. Simmen, R. Xiao, and R. C. M. Simmen (2007)
Physiol Genomics
30, 8-16
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- Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers.
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PNAS
104, 10069-10074
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- Phosphorylation of p68 RNA Helicase Plays a Role in Platelet-derived Growth Factor-induced Cell Proliferation by Up-regulating Cyclin D1 and c-Myc Expression.
- L. Yang, C. Lin, S. Zhao, H. Wang, and Z.-R. Liu (2007)
J. Biol. Chem.
282, 16811-16819
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- Inhibition of Tumor Growth and Metastasis by Depletion of Vesicular Sorting Protein Hrs: Its Regulatory Role on E-Cadherin and {beta}-Catenin.
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Cancer Res.
67, 5162-5171
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- Platelet-Derived Growth Factor Receptor {beta}-Mediated Phosphorylation of MUC1 Enhances Invasiveness in Pancreatic Adenocarcinoma Cells.
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Cancer Res.
67, 5201-5210
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- Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration.
- K. E. Harris and S. K. Beckendorf (2007)
Development
134, 2017-2025
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- Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and {gamma}-secretase-dependent E-cadherin cleavage.
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J. Cell Sci.
120, 1944-1952
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- Par1b Promotes Hepatic-type Lumen Polarity in Madin Darby Canine Kidney Cells via Myosin II- and E-Cadherin-dependent Signaling.
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Mol. Biol. Cell
18, 2203-2215
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- A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3beta-mediated Phosphorylation Regulates the Interaction with beta-Catenin and Its Nuclear Signaling.
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282, 14083-14093
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- In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis.
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Carcinogenesis
28, 1046-1051
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- Wnt Signaling in Polycystic Kidney Disease.
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J. Am. Soc. Nephrol.
18, 1389-1398
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- Adult Mouse Myometrial Label-Retaining Cells Divide in Response to Gonadotropin Stimulation.
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Stem Cells
25, 1317-1325
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- Oxygen sensing and redox signaling: the role of thioredoxin in embryonic development and cardiac diseases.
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Am J Physiol Heart Circ Physiol
292, H2040-H2050
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- Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.
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J. Endocrinol.
193, 93-106
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- Presenilin/{gamma}-Secretase-mediated Cleavage Regulates Association of Leukocyte-Common Antigen-related (LAR) Receptor Tyrosine Phosphatase with beta-Catenin.
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J. Biol. Chem.
282, 9063-9072
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- Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3.
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J. Cell Sci.
120, 1050-1060
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- On the mechanism of wing size determination in fly development.
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PNAS
104, 3835-3840
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