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Science 5 March 2004:
Vol. 303. no. 5663, pp. 1483 - 1487
DOI: 10.1126/science.1094291
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Review

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

W. James Nelson1* and Roel Nusse2,3

The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, ß-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, ß-catenin functions, and cadherin-mediated adhesion.

1 Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
3 Department of Developmental Biology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

* To whom correspondence should be addressed. E-mail: wjnelson{at}stanford.edu

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Platelet-Derived Growth Factor Receptor {beta}-Mediated Phosphorylation of MUC1 Enhances Invasiveness in Pancreatic Adenocarcinoma Cells.
P. K. Singh, Y. Wen, B. J. Swanson, K. Shanmugam, A. Kazlauskas, R. L. Cerny, S. J. Gendler, and M. A. Hollingsworth (2007)
Cancer Res. 67, 5201-5210
   Abstract »    Full Text »    PDF »
Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration.
K. E. Harris and S. K. Beckendorf (2007)
Development 134, 2017-2025
   Abstract »    Full Text »    PDF »
Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and {gamma}-secretase-dependent E-cadherin cleavage.
S. Wu, K.-J. Rhee, M. Zhang, A. Franco, and C. L. Sears (2007)
J. Cell Sci. 120, 1944-1952
   Abstract »    Full Text »    PDF »
Par1b Promotes Hepatic-type Lumen Polarity in Madin Darby Canine Kidney Cells via Myosin II- and E-Cadherin-dependent Signaling.
D. Cohen, Y. Tian, and A. Musch (2007)
Mol. Biol. Cell 18, 2203-2215
   Abstract »    Full Text »    PDF »
A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3beta-mediated Phosphorylation Regulates the Interaction with beta-Catenin and Its Nuclear Signaling.
K. Prager, L. Wang-Eckhardt, R. Fluhrer, R. Killick, E. Barth, H. Hampel, C. Haass, and J. Walter (2007)
J. Biol. Chem. 282, 14083-14093
   Abstract »    Full Text »    PDF »
In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis.
Y. Su, R. R. Eason, Y. Geng, S. Till, T. M. Badger, and R. C.M. Simmen (2007)
Carcinogenesis 28, 1046-1051
   Abstract »    Full Text »    PDF »
Wnt Signaling in Polycystic Kidney Disease.
T. Benzing, M. Simons, and G. Walz (2007)
J. Am. Soc. Nephrol. 18, 1389-1398
   Abstract »    Full Text »    PDF »
Adult Mouse Myometrial Label-Retaining Cells Divide in Response to Gonadotropin Stimulation.
P. P. Szotek, H. L. Chang, L. Zhang, F. Preffer, D. Dombkowski, P. K. Donahoe, and J. Teixeira (2007)
Stem Cells 25, 1317-1325
   Abstract »    Full Text »    PDF »
Oxygen sensing and redox signaling: the role of thioredoxin in embryonic development and cardiac diseases.
M. Kobayashi-Miura, K. Shioji, Y. Hoshino, H. Masutani, H. Nakamura, and J. Yodoi (2007)
Am J Physiol Heart Circ Physiol 292, H2040-H2050
   Abstract »    Full Text »    PDF »
Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.
W. B. Kim, C. J Lewis, K. D McCall, R. Malgor, A. D Kohn, R. T Moon, and L. D Kohn (2007)
J. Endocrinol. 193, 93-106
   Abstract »    Full Text »    PDF »
Presenilin/{gamma}-Secretase-mediated Cleavage Regulates Association of Leukocyte-Common Antigen-related (LAR) Receptor Tyrosine Phosphatase with beta-Catenin.
A. Haapasalo, D. Y. Kim, B. W. Carey, M. K. Turunen, W. H. Pettingell, and D. M. Kovacs (2007)
J. Biol. Chem. 282, 9063-9072
   Abstract »    Full Text »    PDF »
Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3.
C. V. Hojilla, I. Kim, Z. Kassiri, J. E. Fata, H. Fang, and R. Khokha (2007)
J. Cell Sci. 120, 1050-1060
   Abstract »    Full Text »    PDF »
On the mechanism of wing size determination in fly development.
L. Hufnagel, A. A. Teleman, H. Rouault, S. M. Cohen, and B. I. Shraiman (2007)
PNAS 104, 3835-3840
   Abstract »    Full Text »    PDF »


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