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Science 5 March 2004:
Vol. 303. no. 5663, pp. 1483 - 1487
DOI: 10.1126/science.1094291

Review

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

W. James Nelson1* and Roel Nusse2,3

The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, ß-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, ß-catenin functions, and cadherin-mediated adhesion.

1 Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
3 Department of Developmental Biology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

* To whom correspondence should be addressed. E-mail: wjnelson{at}stanford.edu

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Cell-Autonomous beta-Catenin Signaling Regulates Cortical Precursor Proliferation.
G. J. Woodhead, C. A. Mutch, E. C. Olson, and A. Chenn (2006)
J. Neurosci. 26, 12620-12630
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E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion..
K. Strumane, A. Bonnomet, C. Stove, R. Vandenbroucke, B. Nawrocki-Raby, E. Bruyneel, M. Mareel, P. Birembaut, G. Berx, and F. van Roy (2006)
Cancer Res. 66, 10007-10015
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The Hair Follicle as an Estrogen Target and Source.
U. Ohnemus, M. Uenalan, J. Inzunza, J.-A. Gustafsson, and R. Paus (2006)
Endocr. Rev. 27, 677-706
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The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with G{alpha}12