Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Ronadip R. Banerjee,1*Shamina M. Rangwala,1*Jennifer S. Shapiro,1A. Sophie Rich,1Ben Rhoades,1Yong Qi,1Juan Wang,1Michael W. Rajala,2Alessandro Pocai,2Phillipp E. Scherer,2Claire M. Steppan,1Rexford S. Ahima,1Silvana Obici,2Luciano Rossetti,2Mitchell A. Lazar1
The association between obesity and diabetes supports an endocrinerole for the adipocyte in maintaining glucose homeostasis. Herewe report that mice lacking the adipocyte hormone resistin exhibitlow blood glucose levels after fasting, due to reduced hepaticglucose production. This is partly mediated by activation ofadenosine monophosphate–activated protein kinase and decreasedexpression of gluconeogenic enzymes in the liver. The data thussupport a physiological function for resistin in the maintenanceof blood glucose during fasting. Remarkably, lack of resistindiminishes the increase in post-fast blood glucose normallyassociated with increased weight, suggesting a role for resistinin mediating hyperglycemia associated with obesity.
1 Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. 2 Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
* These authors contributed equally to this work.
To whom correspondence should be addressed: E-mail: lazar{at}mail.med.upenn.edu
Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.
S. B. Jorgensen, J. Honeyman, J. S. Oakhill, D. Fazakerley, J. Stockli, B. E. Kemp, and G. R. Steinberg (2009)
Am J Physiol Endocrinol Metab
297, E57-E66
|Abstract »|Full Text »|PDF »
Effects of a high-fat, low- versus high-glycemic index diet: retardation of insulin resistance involves adipose tissue modulation.
E. M. van Schothorst, A. Bunschoten, P. Schrauwen, R. P. Mensink, and J. Keijer (2009)
FASEB J
23, 1092-1101
|Abstract »|Full Text »|PDF »
Adipocyte-specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-activated Receptor {gamma} and CCAAT/Enhancer-binding Proteins.
T. Tomaru, D. J. Steger, M. I. Lefterova, M. Schupp, and M. A. Lazar (2009)
J. Biol. Chem.
284, 6116-6125
|Abstract »|Full Text »|PDF »
Resistin-Like Molecule {alpha} Decreases Glucose Tolerance during Intestinal Inflammation.
A. Munitz, L. Seidu, E. T. Cole, R. Ahrens, S. P. Hogan, and M. E. Rothenberg (2009)
J. Immunol.
182, 2357-2363
|Abstract »|Full Text »|PDF »
Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results From Two Prospective Cohorts.
B. H. Chen, Y. Song, E. L. Ding, C. K. Roberts, J. E. Manson, N. Rifai, J. E. Buring, J. M. Gaziano, and S. Liu (2009)
Diabetes Care
32, 329-334
|Abstract »|Full Text »|PDF »
Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese.
Q. Qi, J. Wang, H. Li, Z. Yu, X. Ye, F. B Hu, O. H Franco, A. Pan, Y. Liu, and X. Lin (2008)
Eur. J. Endocrinol.
159, 585-593
|Abstract »|Full Text »|PDF »
Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c.
B. G. Han, C.-M. Hao, E. E. Tchekneva, Y.-Y. Wang, C. A. Lee, B. Ebrahim, R. C. Harris, T. S. Kern, D. H. Wasserman, M. D. Breyer, et al. (2008)
Am J Physiol Endocrinol Metab
295, E981-E986
|Abstract »|Full Text »|PDF »
Central Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent Fashion.
M. J. Vazquez, C. R. Gonzalez, L. Varela, R. Lage, S. Tovar, S. Sangiao-Alvarellos, L. M. Williams, A. Vidal-Puig, R. Nogueiras, M. Lopez, et al. (2008)
Endocrinology
149, 4534-4543
|Abstract »|Full Text »|PDF »
Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice.
N. S. Singhal, R. T. Patel, Y. Qi, Y.-S. Lee, and R. S. Ahima (2008)
Am J Physiol Endocrinol Metab
295, E331-E338
|Abstract »|Full Text »|PDF »
Early fetal hypoxia leads to growth restriction and myocardial thinning.
M. Ream, A. M. Ray, R. Chandra, and D. M. Chikaraishi (2008)
Am J Physiol Regulatory Integrative Comp Physiol
295, R583-R595
|Abstract »|Full Text »|PDF »
New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice.
J. I. Beier, L. Guo, C. von Montfort, J. P. Kaiser, S. Joshi-Barve, and G. E. Arteel (2008)
J. Pharmacol. Exp. Ther.
325, 801-808
|Abstract »|Full Text »|PDF »
Hypermetabolic Syndrome as a Consequence of Repeated Psychological Stress in Mice.
M. Depke, G. Fusch, G. Domanska, R. Geffers, U. Volker, C. Schuett, and C. Kiank (2008)
Endocrinology
149, 2714-2723
|Abstract »|Full Text »|PDF »
Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring.
X.-H. Yao and B. L. G. Nyomba (2008)
Am J Physiol Regulatory Integrative Comp Physiol
294, R1797-R1806
|Abstract »|Full Text »|PDF »
Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.
M.-J. Lee, H. Lin, C.-W. Liu, M.-H. Wu, W.-J. Liao, H.-H. Chang, H.-C. Ku, Y.-S. Chien, W.-H. Ding, and Y.-H. Kao (2008)
Am J Physiol Cell Physiol
294, C1542-C1551
|Abstract »|Full Text »|PDF »
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
S. Kajimura, P. Seale, T. Tomaru, H. Erdjument-Bromage, M. P. Cooper, J. L. Ruas, S. Chin, P. Tempst, M. A. Lazar, and B. M. Spiegelman (2008)
Genes & Dev.
22, 1397-1409
|Abstract »|Full Text »|PDF »
Adipokines and the Peripheral and Neural Control of Energy Balance.
Long-Term Effects of Central Leptin and Resistin on Body Weight, Insulin Resistance, and {beta}-Cell Function and Mass by the Modulation of Hypothalamic Leptin and Insulin Signaling.
S. Park, S. M. Hong, S. R. Sung, and H. K. Jung (2008)
Endocrinology
149, 445-454
|Abstract »|Full Text »|PDF »
Resistin Is a Key Mediator of Glucose-dependent Insulinotropic Polypeptide (GIP) Stimulation of Lipoprotein Lipase (LPL) Activity in Adipocytes.
S.-J. Kim, C. Nian, and C. H. S. McIntosh (2007)
J. Biol. Chem.
282, 34139-34147
|Abstract »|Full Text »|PDF »
Central Resistin Induces Hepatic Insulin Resistance via Neuropeptide Y.
N. S. Singhal, M. A. Lazar, and R. S. Ahima (2007)
J. Neurosci.
27, 12924-12932
|Abstract »|Full Text »|PDF »
Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at 420 Appears to Be Increased in Younger-Onset Type 2 Diabetes.
M. Ochi, H. Osawa, Y. Hirota, K. Hara, Y. Tabara, Y. Tokuyama, I. Shimizu, A. Kanatsuka, Y. Fujii, J. Ohashi, et al. (2007)
Diabetes
56, 2834-2838
|Abstract »|Full Text »|PDF »
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.
D. Zhang, Z.-X. Liu, C. S. Choi, L. Tian, R. Kibbey, J. Dong, G. W. Cline, P. A. Wood, and G. I. Shulman (2007)
PNAS
104, 17075-17080
|Abstract »|Full Text »|PDF »
Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-{alpha}.
B.-W. Wang, H.-F. Hung, H. Chang, P. Kuan, and K.-G. Shyu (2007)
Am J Physiol Heart Circ Physiol
293, H2305-H2312
|Abstract »|Full Text »|PDF »
The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
E. N. Hampton, M. W. Knuth, J. Li, J. L. Harris, S. A. Lesley, and G. Spraggon (2007)
PNAS
104, 14604-14609
|Abstract »|Full Text »|PDF »
Effects of TNF-{alpha} neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome.
J. Lo, L. E. Bernstein, B. Canavan, M. Torriani, M. B. Jackson, R. S. Ahima, and S. K. Grinspoon (2007)
Am J Physiol Endocrinol Metab
293, E102-E109
|Abstract »|Full Text »|PDF »
Mechanisms of obesity-associated insulin resistance: many choices on the menu.
P. D. Anderson, N. N. Mehta, M. L. Wolfe, C. C. Hinkle, L. Pruscino, L. L. Comiskey, J. Tabita-Martinez, K. F. Sellers, M. R. Rickels, R. S. Ahima, et al. (2007)
J. Clin. Endocrinol. Metab.
92, 2272-2279
|Abstract »|Full Text »|PDF »
Plasma Resistin, Associated With Single Nucleotide Polymorphism -420, Is Correlated With Insulin Resistance, Lower HDL Cholesterol, and High-Sensitivity C-Reactive Protein in the Japanese General Population.
H. Osawa, Y. Tabara, R. Kawamoto, J. Ohashi, M. Ochi, H. Onuma, W. Nishida, K. Yamada, J. Nakura, K. Kohara, et al. (2007)
Diabetes Care
30, 1501-1506
|Abstract »|Full Text »|PDF »
ADIPOKINES AND GUT HORMONES IN END-STAGE RENAL DISEASE.
Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum.
L Senolt, D Housa, Z Vernerova, T Jirasek, R Svobodova, D Veigl, K Anderlova, U Muller-Ladner, K Pavelka, and M Haluzik (2007)
Ann Rheum Dis
66, 458-463
|Abstract »|Full Text »|PDF »
Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase.
Plasma resistin levels correlate with determinants of the metabolic syndrome.
G D Norata, M Ongari, K Garlaschelli, S Raselli, L Grigore, and A L Catapano (2007)
Eur. J. Endocrinol.
156, 279-284
|Abstract »|Full Text »|PDF »
The in Vitro Effects of Resistin on the Innate Immune Signaling Pathway in Isolated Human Subcutaneous Adipocytes.
C. M. Kusminski, N. F. da Silva, S. J. Creely, F. M. Fisher, A. L. Harte, A. R. Baker, S. Kumar, and P. G. McTernan (2007)
J. Clin. Endocrinol. Metab.
92, 270-276
|Abstract »|Full Text »|PDF »
Adipose Tissue-Derived Factors: Impact on Health and Disease.
Brain Adipocytokine Action and Metabolic Regulation.
R. S. Ahima, Y. Qi, N. S. Singhal, M. B. Jackson, and P. E. Scherer (2006)
Diabetes
55, S145-S154
|Abstract »|Full Text »|PDF »
Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency.
Y. Qi, Z. Nie, Y.-S. Lee, N. S. Singhal, P. E. Scherer, M. A. Lazar, and R. S. Ahima (2006)
Diabetes
55, 3083-3090
|Abstract »|Full Text »|PDF »
Inhibition of Gluconeogenesis through Transcriptional Activation of EGR1 and DUSP4 by AMP-activated Kinase.
S. P. Berasi, C. Huard, D. Li, H. H. Shih, Y. Sun, W. Zhong, J. E. Paulsen, E. L. Brown, R. E. Gimeno, and R. V. Martinez (2006)
J. Biol. Chem.
281, 27167-27177
|Abstract »|Full Text »|PDF »
Normative data for adiponectin, resistin, interleukin 6, and leptin/receptor ratio in a healthy Spanish pediatric population: relationship with sex steroids.
G. A Martos-Moreno, V. Barrios, and J. Argente (2006)
Eur. J. Endocrinol.
155, 429-434
|Abstract »|Full Text »|PDF »
Improvement of Insulin Sensitivity after Peroxisome Proliferator-Activated Receptor-{alpha} Agonist Treatment Is Accompanied by Paradoxical Increase of Circulating Resistin Levels.
M. M. Haluzik, Z. Lacinova, M. Dolinkova, D. Haluzikova, D. Housa, A. Horinek, Z. Vernerova, T. Kumstyrova, and M. Haluzik (2006)
Endocrinology
147, 4517-4524
|Abstract »|Full Text »|PDF »
17{beta}-Estradiol Stimulates Resistin Gene Expression in 3T3-L1 Adipocytes via the Estrogen Receptor, Extracellularly Regulated Kinase, and CCAAT/Enhancer Binding Protein-{alpha} Pathways.
Y.-H. Chen, M.-J. Lee, H.-H. Chang, P.-F. Hung, and Y.-H. Kao (2006)
Endocrinology
147, 4496-4504
|Abstract »|Full Text »|PDF »
Obesity and the role of gut and adipose hormones in female reproduction.
G. G. Gosman, H. I. Katcher, and R. S. Legro (2006)
Hum. Reprod. Update
12, 585-601
|Abstract »|Full Text »|PDF »
Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance.
M. J. Bahr, J. Ockenga, K. H. W. Boker, M. P. Manns, and U. J. F. Tietge (2006)
Am J Physiol Endocrinol Metab
291, E199-E206
|Abstract »|Full Text »|PDF »
Heritability of Serum Resistin and Its Genetic Correlation with Insulin Resistance-Related Features in Nondiabetic Caucasians.
C. Menzaghi, A. Coco, L. Salvemini, R. Thompson, S. De Cosmo, A. Doria, and V. Trischitta (2006)
J. Clin. Endocrinol. Metab.
91, 2792-2795
|Abstract »|Full Text »|PDF »
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.
Telmisartan Prevents Obesity and Increases the Expression of Uncoupling Protein 1 in Diet-Induced Obese Mice.
K. Araki, T. Masaki, I. Katsuragi, K. Tanaka, T. Kakuma, and H. Yoshimatsu (2006)
Hypertension
48, 51-57
|Abstract »|Full Text »|PDF »
Liver Adenosine Monophosphate-Activated Kinase-{alpha}2 Catalytic Subunit Is a Key Target for the Control of Hepatic Glucose Production by Adiponectin and Leptin But Not Insulin.
F. Andreelli, M. Foretz, C. Knauf, P. D. Cani, C. Perrin, M. A. Iglesias, B. Pillot, A. Bado, F. Tronche, G. Mithieux, et al. (2006)
Endocrinology
147, 2432-2441
|Abstract »|Full Text »|PDF »
Glucose-induced repression of PPAR{alpha} gene expression in pancreatic {beta}-cells involves PP2A activation and AMPK inactivation..
K. Ravnskjaer, M. Boergesen, L. T Dalgaard, and S. Mandrup (2006)
J. Mol. Endocrinol.
36, 289-299
|Abstract »|Full Text »|PDF »
Increased Serum Resistin in Nonalcoholic Fatty Liver Disease Is Related to Liver Disease Severity and Not to Insulin Resistance.
C. Pagano, G. Soardo, C. Pilon, C. Milocco, L. Basan, G. Milan, D. Donnini, D. Faggian, M. Mussap, M. Plebani, et al. (2006)
J. Clin. Endocrinol. Metab.
91, 1081-1086
|Abstract »|Full Text »|PDF »
Differential Endocrine Responses to Rosiglitazone Therapy in New Mouse Models of Type 2 Diabetes.
E. H. Leiter, P. C. Reifsnyder, W. Zhang, H.-j. Pan, Q. Xiao, and J. Mistry (2006)
Endocrinology
147, 919-926
|Abstract »|Full Text »|PDF »
Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression.
F. Haugen, T. Ranheim, N. K. Harsem, E. Lips, A. C. Staff, and C. A. Drevon (2006)
Am J Physiol Endocrinol Metab
290, E326-E333
|Abstract »|Full Text »|PDF »
Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway.
H.-S. Liu, Y.-H. Chen, P.-F. Hung, and Y.-H. Kao (2006)
Am J Physiol Endocrinol Metab
290, E273-E281
|Abstract »|Full Text »|PDF »
Cross-Sectional Associations of Resistin, Coronary Heart Disease, and Insulin Resistance.
M. S. Burnett, J. M. Devaney, R. J. Adenika, R. Lindsay, and B. V. Howard (2006)
J. Clin. Endocrinol. Metab.
91, 64-68
|Abstract »|Full Text »|PDF »
Elevated Plasma Level of Visfatin/Pre-B Cell Colony-Enhancing Factor in Patients with Type 2 Diabetes Mellitus.
M.-P. Chen, F.-M. Chung, D.-M. Chang, J. C.-R. Tsai, H.-F. Huang, S.-J. Shin, and Y.-J. Lee (2006)
J. Clin. Endocrinol. Metab.
91, 295-299
|Abstract »|Full Text »|PDF »
X. Liang, T. Kanjanabuch, S.-L. Mao, C.-M. Hao, Y.-W. Tang, P. J. Declerck, A. H. Hasty, D. H. Wasserman, A. B. Fogo, and L.-J. Ma (2006)
Am J Physiol Endocrinol Metab
290, E103-E113
|Abstract »|Full Text »|PDF »
Resistin is secreted from macrophages in atheromas and promotes atherosclerosis.
H. S. Jung, K.-H. Park, Y. M. Cho, S. S. Chung, H. J. Cho, S. Y. Cho, S. J. Kim, S. Y. Kim, H. K. Lee, and K. S. Park (2006)
Cardiovasc Res
69, 76-85
|Abstract »|Full Text »|PDF »
Resistin-like Molecule {beta} Activates MAPKs, Suppresses Insulin Signaling in Hepatocytes, and Induces Diabetes, Hyperlipidemia, and Fatty Liver in Transgenic Mice on a High Fat Diet.
A. Kushiyama, N. Shojima, T. Ogihara, K. Inukai, H. Sakoda, M. Fujishiro, Y. Fukushima, M. Anai, H. Ono, N. Horike, et al. (2005)
J. Biol. Chem.
280, 42016-42025
|Abstract »|Full Text »|PDF »
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin.
R. J. Shaw, K. A. Lamia, D. Vasquez, S.-H. Koo, N. Bardeesy, R. A. DePinho, M. Montminy, and L. C. Cantley (2005)
Science
310, 1642-1646
|Abstract »|Full Text »|PDF »
Adipokines: implications for female fertility and obesity.
M Mitchell, D T Armstrong, R L Robker, and R J Norman (2005)
Reproduction
130, 583-597
|Abstract »|Full Text »|PDF »
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats.
M. M. Assifi, G. Suchankova, S. Constant, M. Prentki, A. K. Saha, and N. B. Ruderman (2005)
Am J Physiol Endocrinol Metab
289, E794-E800
|Abstract »|Full Text »|PDF »
Estrogen Regulation of Adiposity and Fuel Partitioning: EVIDENCE OF GENOMIC AND NON-GENOMIC REGULATION OF LIPOGENIC AND OXIDATIVE PATHWAYS.
T. M. D'Eon, S. C. Souza, M. Aronovitz, M. S. Obin, S. K. Fried, and A. S. Greenberg (2005)
J. Biol. Chem.
280, 35983-35991
|Abstract »|Full Text »|PDF »
Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men.
A. Tirosh, I. Shai, D. Tekes-Manova, E. Israeli, D. Pereg, T. Shochat, I. Kochba, A. Rudich, and the Israeli Diabetes Research Group (2005)
N. Engl. J. Med.
353, 1454-1462
|Abstract »|Full Text »|PDF »
Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.
E. Carvalho, K. Kotani, O. D. Peroni, and B. B. Kahn (2005)
Am J Physiol Endocrinol Metab
289, E551-E561
|Abstract »|Full Text »|PDF »
Mouse and Human Resistins Impair Glucose Transport in Primary Mouse Cardiomyocytes, and Oligomerization Is Required for This Biological Action.
C. Graveleau, V. G. Zaha, A. Mohajer, R. R. Banerjee, N. Dudley-Rucker, C. M. Steppan, M. W. Rajala, P. E. Scherer, R. S. Ahima, M. A. Lazar, et al. (2005)
J. Biol. Chem.
280, 31679-31685
|Abstract »|Full Text »|PDF »
Central administration of resistin promotes short-term satiety in rats.
S. Tovar, R. Nogueiras, L. Y C Tung, T. R Castaneda, M. J. Vazquez, A. Morris, L. M Williams, S. L Dickson, and C. Dieguez (2005)
Eur. J. Endocrinol.
153, R1-R5
|Abstract »|Full Text »|PDF »
Increased Serum Resistin in Adults with Prader-Willi Syndrome Is Related to Obesity and Not to Insulin Resistance.
C. Pagano, O. Marin, A. Calcagno, P. Schiappelli, C. Pilon, G. Milan, M. Bertelli, E. Fanin, G. Andrighetto, G. Federspil, et al. (2005)
J. Clin. Endocrinol. Metab.
90, 4335-4340
|Abstract »|Full Text »|PDF »
Overexpression of Glucose-6-Phosphate Dehydrogenase Is Associated with Lipid Dysregulation and Insulin Resistance in Obesity.
J. Park, H. K. Rho, K. H. Kim, S. S. Choe, Y. S. Lee, and J. B. Kim (2005)
Mol. Cell. Biol.
25, 5146-5157
|Abstract »|Full Text »|PDF »
Resistin expression and plasma concentration peak at different times during pregnancy in rats.
S. Caja, I. Martinez, M. Abelenda, and M. Puerta (2005)
J. Endocrinol.
185, 551-559
|Abstract »|Full Text »|PDF »
Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue.
H. Molina, J. Bunkenborg, G. H. Reddy, B. Muthusamy, P. J. Scheel, and A. Pandey (2005)
Mol. Cell. Proteomics
4, 637-650
|Abstract »|Full Text »|PDF »
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver.
M. Foretz, N. Ancellin, F. Andreelli, Y. Saintillan, P. Grondin, A. Kahn, B. Thorens, S. Vaulont, and B. Viollet (2005)
Diabetes
54, 1331-1339
|Abstract »|Full Text »|PDF »
Recombinant Human FIZZ3/Resistin Stimulates Lipolysis in Cultured Human Adipocytes, Mouse Adipose Explants, and Normal Mice.
T. Ort, A. A. Arjona, J. R. MacDougall, P. J. Nelson, M. E. Rothenberg, F. Wu, A. Eisen, and Y.-D. C. Halvorsen (2005)
Endocrinology
146, 2200-2209
|Abstract »|Full Text »|PDF »
IGF-I downregulates resistin gene expression and protein secretion.
Y.-H. Chen, P.-F. Hung, and Y.-H. Kao (2005)
Am J Physiol Endocrinol Metab
288, E1019-E1027
|Abstract »|Full Text »|PDF »
Adiponectin, Leptin, and Erythrocyte Sodium/Lithium Countertransport Activity, But Not Resistin, Are Related to Glucose Metabolism in Growth Hormone-Deficient Adults.
J. Svensson, H. Herlitz, P.-A. Lundberg, and G. Johannsson (2005)
J. Clin. Endocrinol. Metab.
90, 2290-2296
|Abstract »|Full Text »|PDF »
Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue.
C. Kurlawalla-Martinez, B. Stiles, Y. Wang, S. U. Devaskar, B. B. Kahn, and H. Wu (2005)
Mol. Cell. Biol.
25, 2498-2510
|Abstract »|Full Text »|PDF »
Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia.
J. H. Lee, J. W. Bullen Jr., V. L. Stoyneva, and C. S. Mantzoros (2005)
Am J Physiol Endocrinol Metab
288, E625-E632
|Abstract »|Full Text »|PDF »
Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality.
S. Fraser, P. Mount, R. Hill, V. Levidiotis, F. Katsis, D. Stapleton, B. E. Kemp, and D. A. Power (2005)
Am J Physiol Renal Physiol
288, F578-F586
|Abstract »|Full Text »|PDF »
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans.
M. P. Reilly, M. Lehrke, M. L. Wolfe, A. Rohatgi, M. A. Lazar, and D. J. Rader (2005)
Circulation
111, 932-939
|Abstract »|Full Text »|PDF »
Activation of SOCS-3 by Resistin.
C. M. Steppan, J. Wang, E. L. Whiteman, M. J. Birnbaum, and M. A. Lazar (2005)
Mol. Cell. Biol.
25, 1569-1575
|Abstract »|Full Text »|PDF »
Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid.
F. Haugen, N. Zahid, K. T. Dalen, K. Hollung, H. I. Nebb, and C. A. Drevon (2005)
J. Lipid Res.
46, 143-153
|Abstract »|Full Text »|PDF »
Adenovirus-Mediated High Expression of Resistin Causes Dyslipidemia in Mice.
N. Sato, K. Kobayashi, T. Inoguchi, N. Sonoda, M. Imamura, N. Sekiguchi, N. Nakashima, and H. Nawata (2005)
Endocrinology
146, 273-279
|Abstract »|Full Text »|PDF »
Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase Pathways.
P. Calabro, I. Samudio, J. T. Willerson, and E. T.H. Yeh (2004)
Circulation
110, 3335-3340
|Abstract »|Full Text »|PDF »
Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids: ECTOPIC EXPRESSION OF DESNUTRIN INCREASES TRIGLYCERIDE HYDROLYSIS.
J. A. Villena, S. Roy, E. Sarkadi-Nagy, K.-H. Kim, and H. S. Sul (2004)
J. Biol. Chem.
279, 47066-47075
|Abstract »|Full Text »|PDF »
Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians.
Metabolic Adaptations in the Absence of Perilipin: INCREASED {beta}-OXIDATION AND DECREASED HEPATIC GLUCOSE PRODUCTION ASSOCIATED WITH PERIPHERAL INSULIN RESISTANCE BUT NORMAL GLUCOSE TOLERANCE IN PERILIPIN-NULL MICE.
P. K. Saha, H. Kojima, J. Martinez-Botas, A. L. Sunehag, and L. Chan (2004)
J. Biol. Chem.
279, 35150-35158
|Abstract »|Full Text »|PDF »
Wnt10b Inhibits Development of White and Brown Adipose Tissues.
K. A. Longo, W. S. Wright, S. Kang, I. Gerin, S.-H. Chiang, P. C. Lucas, M. R. Opp, and O. A. MacDougald (2004)
J. Biol. Chem.
279, 35503-35509
|Abstract »|Full Text »|PDF »
The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate Treatment.
S. Mandard, F. Zandbergen, N. S. Tan, P. Escher, D. Patsouris, W. Koenig, R. Kleemann, A. Bakker, F. Veenman, W. Wahli, et al. (2004)
J. Biol. Chem.
279, 34411-34420
|Abstract »|Full Text »|PDF »
Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia.
S. M. Rangwala, A. S. Rich, B. Rhoades, J. S. Shapiro, S. Obici, L. Rossetti, and M. A. Lazar (2004)
Diabetes
53, 1937-1941
|Abstract »|Full Text »|PDF »
Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting.
M. W. Rajala, Y. Qi, H. R. Patel, N. Takahashi, R. Banerjee, U. B. Pajvani, M. K. Sinha, R. L. Gingerich, P. E. Scherer, and R. S. Ahima (2004)
Diabetes
53, 1671-1679
|Abstract »|Full Text »|PDF »
Adipose Tissue as an Endocrine Organ.
E. E. Kershaw and J. S. Flier (2004)
J. Clin. Endocrinol. Metab.
89, 2548-2556
|Abstract »|Full Text »|PDF »
Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function.
B. J. Goldstein and R. Scalia (2004)
J. Clin. Endocrinol. Metab.
89, 2563-2568
|Abstract »|Full Text »|PDF »
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones.
S. D. Patel, M. W. Rajala, L. Rossetti, P. E. Scherer, and L. Shapiro (2004)
Science
304, 1154-1158
|Abstract »|Full Text »|PDF »
Papers of Note.
(2004)
Sci. Aging Knowl. Environ.
2004, nw7-7
|Full Text »
To whom correspondence should be addressed: E-mail: 
