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Science 20 February 2004: Vol. 303. no. 5661, pp. 1157 - 1162 DOI: 10.1126/science.1093535
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Research Articles
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Tania Singer,1*
Ben Seymour,1
John O'Doherty,1
Holger Kaube,2
Raymond J. Dolan,1
Chris D. Frith1
Our ability to have an experience of another's pain is characteristic of empathy. Using functional imaging, we assessed brain activity while volunteers experienced a painful stimulus and compared it to that elicited when they observed a signal indicating that their loved onepresent in the same roomwas receiving a similar pain stimulus. Bilateral anterior insula (AI), rostral anterior cingulate cortex (ACC), brainstem, and cerebellum were activated when subjects received pain and also by a signal that a loved one experienced pain. AIand ACC activation correlated with individual empathy scores. Activity in the posterior insula/secondary somatosensory cortex, the sensorimotor cortex (SI/MI), and the caudal ACC was specific to receiving pain. Thus, a neural response in AIand rostral ACC, activated in common for "self" and "other" conditions, suggests that the neural substrate for empathic experience does not involve the entire "pain matrix." We conclude that only that part of the pain network associated with its affective qualities, but not its sensory qualities, mediates empathy.
1 Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK.
2 Headache Group, Institute of Neurology, University College of London, Queen Square, WC1N 3BG London, UK.
* To whom correspondence should be addressed. E-mail: t.singer{at}fil.ion.ucl.ac.uk
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57, 525-550
| Abstract »
| PDF »
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- J. M. Vivona (2009)
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57, 569-573
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- J. Fujiwara, P. N. Tobler, M. Taira, T. Iijima, and K.-I. Tsutsui (2009)
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| Full Text »
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| PDF »
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28, 10509-10516
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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56, 769-781
| PDF »
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Soc Cogn Affect Neurosci
3, 204-217
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- G. Knoblich and N. Sebanz (2008)
Phil Trans R Soc B
363, 2021-2031
| Abstract »
| Full Text »
| PDF »
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- C. D Frith (2008)
Phil Trans R Soc B
363, 2033-2039
| Abstract »
| Full Text »
| PDF »
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| Full Text »
| PDF »
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- C. McCabe, E. T. Rolls, A. Bilderbeck, and F. McGlone (2008)
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| Abstract »
| Full Text »
| PDF »
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- K. N. Ochsner, J. Zaki, J. Hanelin, D. H. Ludlow, K. Knierim, T. Ramachandran, G. H. Glover, and S. C. Mackey (2008)
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| Abstract »
| Full Text »
| PDF »
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320, 1092-1095
| Abstract »
| Full Text »
| PDF »
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- K. Preuschoff, S. R. Quartz, and P. Bossaerts (2008)
J. Neurosci.
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| Abstract »
| Full Text »
| PDF »
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- S. D. PRESTON and R. B. STANSFIELD (2008)
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| Abstract »
| PDF »
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- F. Benuzzi, F. Lui, D. Duzzi, P. F. Nichelli, and C. A. Porro (2008)
J. Neurosci.
28, 923-931
| Abstract »
| Full Text »
| PDF »
- Differential effects of tryptophan depletion on emotion processing according to face direction.
- J. H. G. Williams, D. I. Perrett, G. D. Waiter, and S. Pechey (2007)
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| Abstract »
| Full Text »
| PDF »
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- K. Fliessbach, B. Weber, P. Trautner, T. Dohmen, U. Sunde, C. E. Elger, and A. Falk (2007)
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318, 1305-1308
| Abstract »
| Full Text »
| PDF »
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104, 17825-17830
| Abstract »
| Full Text »
| PDF »
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- I. Bufalari, T. Aprile, A. Avenanti, F. Di Russo, and S. M. Aglioti (2007)
Cereb Cortex
17, 2553-2561
| Abstract »
| Full Text »
| PDF »
- Gender difference in neural response to psychological stress.
- J. Wang, M. Korczykowski, H. Rao, Y. Fan, J. Pluta, R. C. Gur, B. S. McEwen, and J. A. Detre (2007)
Soc Cogn Affect Neurosci
2, 227-239
| Abstract »
| Full Text »
| PDF »
- Empathy and Judging Other's Pain: An fMRI Study of Alexithymia.
- Y. Moriguchi, J. Decety, T. Ohnishi, M. Maeda, T. Mori, K. Nemoto, H. Matsuda, and G. Komaki (2007)
Cereb Cortex
17, 2223-2234
| Abstract »
| Full Text »
| PDF »
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- N. A. Harrison and H. D. Critchley (2007)
The British Journal of Psychiatry
191, 192-194
| Abstract »
| Full Text »
| PDF »
- Threatening a rubber hand that you feel is yours elicits a cortical anxiety response.
- H. H. Ehrsson, K. Wiech, N. Weiskopf, R. J. Dolan, and R. E. Passingham (2007)
PNAS
104, 9828-9833
| Abstract »
| Full Text »
| PDF »
- The Rooting of the Mind in the Body: New Links Between Attachment Theory and Psychoanalytic Thought.
- P. Fonagy and M. Target (2007)
J Am Psychoanal Assoc
55, 411-456
| Abstract »
| PDF »
- Embodiment and Our Immersion With Others: Commentary On Fonagy and Target.
- R. N. Emde (2007)
J Am Psychoanal Assoc
55, 485-492
| PDF »
- Caregivers' Responses to Pain in Their Children in the Emergency Department.
- R. W. Smith, V. Shah, R. D. Goldman, and A. Taddio (2007)
Arch Pediatr Adolesc Med
161, 578-582
| Abstract »
| Full Text »
| PDF »
- Embodying Emotion.
- P. M. Niedenthal (2007)
Science
316, 1002-1005
| Abstract »
| Full Text »
| PDF »
- Inner Experience of Pain: Imagination of Pain While Viewing Images Showing Painful Events Forms Subjective Pain Representation in Human Brain.
- Y. Ogino, H. Nemoto, K. Inui, S. Saito, R. Kakigi, and F. Goto (2007)
Cereb Cortex
17, 1139-1146
| Abstract »
| Full Text »
| PDF »
- Hypnosis and Surgery: Past, Present, and Future.
- A. H. K. Wobst (2007)
Anesth. Analg.
104, 1199-1208
| Abstract »
| Full Text »
| PDF »
- The social brain?.
- C. D Frith (2007)
Phil Trans R Soc B
362, 671-678
| Abstract »
| Full Text »
| PDF »
- Memory Traces of Pain in Human Cortex.
- M.-C. Albanese, E. G. Duerden, P. Rainville, and G. H. Duncan (2007)
J. Neurosci.
27, 4612-4620
| Abstract »
| Full Text »
| PDF »
- Learning to fear what others have feared before.
- K. Ochsner (2007)
Soc Cogn Affect Neurosci
2, 1-2
| Full Text »
| PDF »
- Intentional Attunement: Mirror Neurons and the Neural Underpinnings of Interpersonal Relations.
- V. Gallese, M. N. Eagle, and P. Migone (2007)
J Am Psychoanal Assoc
55, 131-175
| Abstract »
| PDF »
- The human mirror neuron system: A link between action observation and social skills.
- L. M. Oberman, J. A. Pineda, and V. S. Ramachandran (2007)
Soc Cogn Affect Neurosci
2, 62-66
| Abstract »
| Full Text »
| PDF »
- Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control.
- W. W. Seeley, V. Menon, A. F. Schatzberg, J. Keller, G. H. Glover, H. Kenna, A. L. Reiss, and M. D. Greicius (2007)
J. Neurosci.
27, 2349-2356
| Abstract »
| Full Text »
| PDF »
- Brain Activation during Sight Gags and Language-Dependent Humor.
- K. K. Watson, B. J. Matthews, and J. M. Allman (2007)
Cereb Cortex
17, 314-324
| Abstract »
| Full Text »
| PDF »
- Functional Magnetic Resonance Imaging Investigation of Overlapping Lateral Occipitotemporal Activations Using Multi-Voxel Pattern Analysis.
- P. E. Downing, A. J. Wiggett, and M. V. Peelen (2007)
J. Neurosci.
27, 226-233
| Abstract »
| Full Text »
| PDF »
- Altered Pain Processing in Veterans With Posttraumatic Stress Disorder.
- E. Geuze, H. G. M. Westenberg, A. Jochims, C. S. de Kloet, M. Bohus, E. Vermetten, and C. Schmahl (2007)
Arch Gen Psychiatry
64, 76-85
| Abstract »
| Full Text »
| PDF »
- The Compassionate Brain: Humans Detect Intensity of Pain from Another's Face.
- M. V. Saarela, Y. Hlushchuk, A. C. d. C. Williams, M. Schurmann, E. Kalso, and R. Hari (2007)
Cereb Cortex
17, 230-237
| Abstract »
| Full Text »
| PDF »
- Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain..
- M. N. Baliki, D. R. Chialvo, P. Y. Geha, R. M. Levy, R. N. Harden, T. B. Parrish, and A. V. Apkarian (2006)
J. Neurosci.
26, 12165-12173
| Abstract »
| Full Text »
| PDF »
- Emotional modulation of pain: is it the sensation or what we recall?.
- F. Godinho, M. Magnin, M. Frot, C. Perchet, and L. Garcia-Larrea (2006)
J. Neurosci.
26, 11454-11461
| Abstract »
| Full Text »
| PDF »
- Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women..
- S. E. Kennedy, R. A. Koeppe, E. A. Young, and J.-K. Zubieta (2006)
Arch Gen Psychiatry
63, 1199-1208
| Abstract »
| Full Text »
| PDF »
- Perceiving an opponent's loss: gender-related differences in the medial-frontal negativity.
- H. Fukushima and K. Hiraki (2006)
Soc Cogn Affect Neurosci
1, 149-157
| Abstract »
| Full Text »
| PDF »
- Imitating expressions: emotion-specific neural substrates in facial mimicry.
- T.-W. Lee, O. Josephs, R. J. Dolan, and H. D. Critchley (2006)
Soc Cogn Affect Neurosci
1, 122-135
| Abstract »
| Full Text »
| PDF »
- A role for the macaque anterior cingulate gyrus in social valuation..
- P. H. Rudebeck, M. J. Buckley, M. E. Walton, and M. F. S. Rushworth (2006)
Science
313, 1310-1312
| Abstract »
| Full Text »
| PDF »
- Is pain the price of empathy? The perception of others' pain in patients with congenital insensitivity to pain.
- N. Danziger, K. M. Prkachin, and J.-C. Willer (2006)
Brain
129, 2494-2507
| Abstract »
| Full Text »
| PDF »
- Enhanced Presynaptic Neurotransmitter Release in the Anterior Cingulate Cortex of Mice with Chronic Pain..
- M.-G. Zhao, S. W Ko, L.-J. Wu, H. Toyoda, H. Xu, J. Quan, J. Li, Y. Jia, M. Ren, Z. C. Xu, et al. (2006)
J. Neurosci.
26, 8923-8930
| Abstract »
| Full Text »
| PDF »
|
|