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Science 6 February 2004:
Vol. 303. no. 5659, pp. 853 - 856
DOI: 10.1126/science.1091162
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Reports

Selective D2 Receptor Actions on the Functional Circuitry of Working Memory

Min Wang,* Susheel Vijayraghavan, Patricia S. Goldman-Rakic{dagger}

Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.

Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.



{dagger} Deceased.

* To whom correspondence should be addressed. E-mail: min.wang{at}yale.edu

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