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TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Neil A. Bhowmick,1,4Anna Chytil,1David Plieth,2Agnieszka E. Gorska,1,4Nancy Dumont,2,4Scott Shappell,3,4M. Kay Washington,3,4Eric G. Neilson,2,4Harold L. Moses1,3,4*
Stromal cells can have a significant impact on the carcinogenicprocess in adjacent epithelia. The role of transforming growthfactor–ß (TGF-ß) signaling in suchepithelial-mesenchymal interactions was determined by conditionalinactivation of the TGF-ß type II receptor gene inmouse fibroblasts (Tgfbr2fspKO). The loss of TGF-ßresponsiveness in fibroblasts resulted in intraepithelial neoplasiain prostate and invasive squamous cell carcinoma of the forestomach,both associated with an increased abundance of stromal cells.Activation of paracrine hepatocyte growth factor (HGF) signalingwas identified as one possible mechanism for stimulation ofepithelial proliferation. Thus, TGF-ß signaling infibroblasts modulates the growth and oncogenic potential ofadjacent epithelia in selected tissues.
1 Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. 2 Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. 3 Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. 4 the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
* To whom correspondence should be addressed. E-mail: hal.moses{at}vanderbilt.edu.
Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis.
H. Tanjore, X. C. Xu, V. V. Polosukhin, A. L. Degryse, B. Li, W. Han, T. P. Sherrill, D. Plieth, E. G. Neilson, T. S. Blackwell, et al. (2009)
Am. J. Respir. Crit. Care Med.
180, 657-665
|Abstract »|Full Text »|PDF »
Autoimmune pancreatitis results from loss of TGF{beta} signalling in S100A4-positive dendritic cells.
C S Boomershine, A Chamberlain, P Kendall, A-R Afshar-Sharif, H Huang, M K Washington, W E Lawson, J W Thomas, T S Blackwell, and N A Bhowmick (2009)
Gut
58, 1267-1274
|Abstract »|Full Text »|PDF »
Differential Influence of Normal and Cancer-Associated Fibroblasts on the Growth of Human Epithelial Cells in an In vitro Cocultivation Model of Prostate Cancer.
N. Paland, I. Kamer, I. Kogan-Sakin, S. Madar, N. Goldfinger, and V. Rotter (2009)
Mol. Cancer Res.
7, 1212-1223
|Abstract »|Full Text »|PDF »
Progressive Tumor Formation in Mice with Conditional Deletion of TGF-{beta} Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway.
Y. Bian, A. Terse, J. Du, B. Hall, A. Molinolo, P. Zhang, W. Chen, K. C. Flanders, J. S. Gutkind, L. M. Wakefield, et al. (2009)
Cancer Res.
69, 5918-5926
|Abstract »|Full Text »|PDF »
Fibroblast Growth Factor Receptor 2-Positive Fibroblasts Provide a Suitable Microenvironment for Tumor Development and Progression in Esophageal Carcinoma.
C. Zhang, L. Fu, J. Fu, L. Hu, H. Yang, T.-H. Rong, Y. Li, H. Liu, S.-B. Fu, Y.-X. Zeng, et al. (2009)
Clin. Cancer Res.
15, 4017-4027
|Abstract »|Full Text »|PDF »
Quis Custodiet Ipsos Custodies: Who Watches the Watchmen?.
C. M. Ghajar, R. Meier, and M. J. Bissell (2009)
Am. J. Pathol.
174, 1996-1999
|Abstract »|Full Text »|PDF »
Homeostatic Role of Transforming Growth Factor-{beta} in the Oral Cavity and Esophagus of Mice and Its Expression by Mast Cells in These Tissues.
A. Vitsky, J. Waire, R. Pawliuk, A. Bond, D. Matthews, E. LaCasse, M. L. Hawes, C. Nelson, S. Richards, P. A. Piepenhagen, et al. (2009)
Am. J. Pathol.
174, 2137-2149
|Abstract »|Full Text »|PDF »
Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7.
M. Sakaguchi, K. Kataoka, F. Abarzua, R. Tanimoto, M. Watanabe, H. Murata, S. S. Than, K. Kurose, Y. Kashiwakura, K. Ochiai, et al. (2009)
J. Biol. Chem.
284, 14236-14244
|Abstract »|Full Text »|PDF »
The Linear No-Threshold Relationship Is Inconsistent with Radiation Biologic and Experimental Data.
M. Tubiana, L. E. Feinendegen, C. Yang, and J. M. Kaminski (2009)
Radiology
251, 13-22
|Full Text »|PDF »
No TGFBRII germline mutations in juvenile polyposis patients without SMAD4 or BMPR1A mutation.
L A A Brosens, W A van Hattem, M C E Kools, C Ezendam, F H Morsink, W W J de Leng, F M Giardiello, and G J A Offerhaus (2009)
Gut
58, 154-156
|Full Text »|PDF »
Modulated expression of WFDC1 during carcinogenesis and cellular senescence.
S. Madar, R. Brosh, Y. Buganim, O. Ezra, I. Goldstein, H. Solomon, I. Kogan, N. Goldfinger, H. Klocker, and V. Rotter (2009)
Carcinogenesis
30, 20-27
|Abstract »|Full Text »|PDF »
Wnt1 Expression Induces Short-Range and Long-Range Cell Recruitments That Modify Mammary Tumor Development and Are Not Induced by a Cell-Autonomous {beta}-Catenin Effector.
Y. C. Kim, R. J. Clark, E. A. Ranheim, and C. M. Alexander (2008)
Cancer Res.
68, 10145-10153
|Abstract »|Full Text »|PDF »
Perturbation of transforming growth factor (TGF)-ss1 association with latent TGF-{beta} binding protein yields inflammation and tumors.
K. Yoshinaga, H. Obata, V. Jurukovski, R. Mazzieri, Y. Chen, L. Zilberberg, D. Huso, J. Melamed, P. Prijatelj, V. Todorovic, et al. (2008)
PNAS
105, 18758-18763
|Abstract »|Full Text »|PDF »
Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis.
S.-Y. Sung, C.-L. Hsieh, A. Law, H. E. Zhau, S. Pathak, A. S. Multani, S. Lim, I. M. Coleman, L.-C. Wu, W. D. Figg, et al. (2008)
Cancer Res.
68, 9996-10003
|Abstract »|Full Text »|PDF »
Androgenic Control of Transforming Growth Factor-{beta} Signaling in Prostate Epithelial Cells through Transcriptional Suppression of Transforming Growth Factor-{beta} Receptor II.
K. Song, H. Wang, T. L. Krebs, S.-J. Kim, and D. Danielpour (2008)
Cancer Res.
68, 8173-8182
|Abstract »|Full Text »|PDF »
Reconstitution of Schwannian Stroma in Neuroblastomas Using Human Bone Marrow Stromal Cells.
W. Du, N. Hozumi, M. Sakamoto, J.-i. Hata, and T. Yamada (2008)
Am. J. Pathol.
173, 1153-1164
|Abstract »|Full Text »|PDF »
Macrophages define the invasive microenvironment in breast cancer.
Targeting the stromal androgen receptor in primary prostate tumors at earlier stages.
Y. Niu, S. Altuwaijri, S. Yeh, K.-P. Lai, S. Yu, K.-H. Chuang, S.-P. Huang, H. Lardy, and C. Chang (2008)
PNAS
105, 12188-12193
|Abstract »|Full Text »|PDF »
Dissecting out the genetic origins of Barrett's oesophagus.
Opposite Effects of Dihydrosphingosine 1-Phosphate and Sphingosine 1-Phosphate on Transforming Growth Factor-{beta}/Smad Signaling Are Mediated through the PTEN/PPM1A-dependent Pathway.
S. Bu, B. Kapanadze, T. Hsu, and M. Trojanowska (2008)
J. Biol. Chem.
283, 19593-19602
|Abstract »|Full Text »|PDF »
Stromal Fibroblasts Activated by Tumor Cells Promote Angiogenesis in Mouse Gastric Cancer.
X. Guo, H. Oshima, T. Kitmura, M. M. Taketo, and M. Oshima (2008)
J. Biol. Chem.
283, 19864-19871
|Abstract »|Full Text »|PDF »
Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched.
J. M. Garcia, V. Garcia, C. Pena, G. Dominguez, J. Silva, R. Diaz, P. Espinosa, M. J. Citores, M. Collado, and F. Bonilla (2008)
RNA
14, 1424-1432
|Abstract »|Full Text »|PDF »
Endocannabinoids in endocrine and related tumours.
M. Bifulco, A. M. Malfitano, S. Pisanti, and C. Laezza (2008)
Endocr. Relat. Cancer
15, 391-408
|Abstract »|Full Text »|PDF »
An Anti-Transforming Growth Factor {beta} Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments.
J.-S. Nam, M. Terabe, M. Mamura, M.-J. Kang, H. Chae, C. Stuelten, E. Kohn, B. Tang, H. Sabzevari, M. R. Anver, et al. (2008)
Cancer Res.
68, 3835-3843
|Abstract »|Full Text »|PDF »
Methylation Silencing of Transforming Growth Factor-{beta} Receptor Type II in Rat Prostate Cancers.
S. Yamashita, S. Takahashi, N. McDonell, N. Watanabe, T. Niwa, K. Hosoya, Y. Tsujino, T. Shirai, and T. Ushijima (2008)
Cancer Res.
68, 2112-2121
|Abstract »|Full Text »|PDF »
Transforming Growth Factor {beta} Controls the Directional Migration of Hepatocyte Cohorts by Modulating Their Adhesion to Fibronectin.
R. F. Hwang, T. Moore, T. Arumugam, V. Ramachandran, K. D. Amos, A. Rivera, B. Ji, D. B. Evans, and C. D. Logsdon (2008)
Cancer Res.
68, 918-926
|Abstract »|Full Text »|PDF »
Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer.
A. J. Trimboli, K. Fukino, A. de Bruin, G. Wei, L. Shen, S. M. Tanner, N. Creasap, T. J. Rosol, M. L. Robinson, C. Eng, et al. (2008)
Cancer Res.
68, 937-945
|Abstract »|Full Text »|PDF »
Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment.
H. Koyama, N. Kobayashi, M. Harada, M. Takeoka, Y. Kawai, K. Sano, M. Fujimori, J. Amano, T. Ohhashi, R. Kannagi, et al. (2008)
Am. J. Pathol.
172, 179-193
|Abstract »|Full Text »|PDF »
Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development.
Y. Bian, T. J. Knobloch, M. Sadim, V. Kaklamani, A. Raji, G.-Y. Yang, C. M. Weghorst, and B. Pasche (2007)
Hum. Mol. Genet.
16, 3128-3135
|Abstract »|Full Text »|PDF »
Androgen Receptor Regulation of the Versican Gene through an Androgen Response Element in the Proximal Promoter.
J. T. Read, M. Rahmani, S. Boroomand, S. Allahverdian, B. M. McManus, and P. S. Rennie (2007)
J. Biol. Chem.
282, 31954-31963
|Abstract »|Full Text »|PDF »
Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.
Y Vasilopoulos, V Gkretsi, M Armaka, V Aidinis, and G Kollias (2007)
Ann Rheum Dis
66, iii23-iii28
|Abstract »|Full Text »|PDF »
Tissue-Specific Consequences of Cyclin D1 Overexpression in Prostate Cancer Progression.
Y. He, O. E. Franco, M. Jiang, K. Williams, H. D. Love, I. M. Coleman, P. S. Nelson, and S. W. Hayward (2007)
Cancer Res.
67, 8188-8197
|Abstract »|Full Text »|PDF »
TGF-{beta} signaling is essential for joint morphogenesis.
A. Spagnoli, L. O'Rear, R. L. Chandler, F. Granero-Molto, D. P. Mortlock, A. E. Gorska, J. A. Weis, L. Longobardi, A. Chytil, K. Shimer, et al. (2007)
J. Cell Biol.
177, 1105-1117
|Abstract »|Full Text »|PDF »
Integrin {alpha}11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.
C.-Q. Zhu, S. N. Popova, E. R. S. Brown, D. Barsyte-Lovejoy, R. Navab, W. Shih, M. Li, M. Lu, I. Jurisica, L. Z. Penn, et al. (2007)
PNAS
104, 11754-11759
|Abstract »|Full Text »|PDF »
TGF-beta-neutralizing antibodies improve pulmonary alveologenesis and vasculogenesis in the injured newborn lung.
H. Nakanishi, T. Sugiura, J. B. Streisand, S. M. Lonning, and J. D. Roberts Jr (2007)
Am J Physiol Lung Cell Mol Physiol
293, L151-L161
|Abstract »|Full Text »|PDF »
Transforming Growth Factor-{beta} Signaling in Prostate Stromal Cells Supports Prostate Carcinoma Growth by Up-regulating Stromal Genes Related to Tissue Remodeling.
E. V. Verona, A. G. Elkahloun, J. Yang, A. Bandyopadhyay, I-T. Yeh, and L.-Z. Sun (2007)
Cancer Res.
67, 5737-5746
|Abstract »|Full Text »|PDF »
Interaction between Cancer Cells and Stromal Fibroblasts Is Required for Activation of the uPAR-uPA-MMP-2 Cascade in Pancreatic Cancer Metastasis.
Y. He, X.-d. Liu, Z.-y. Chen, J. Zhu, Y. Xiong, K. Li, J.-h. Dong, and X. Li (2007)
Clin. Cancer Res.
13, 3115-3124
|Abstract »|Full Text »|PDF »
Tumor-Specific Efficacy of Transforming Growth Factor-{beta}RI Inhibition in Eker Rats.
N. J. Laping, J. I. Everitt, K. S. Frazier, M. Burgert, M. J. Portis, C. Cadacio, L. I. Gold, and C. L. Walker (2007)
Clin. Cancer Res.
13, 3087-3099
|Abstract »|Full Text »|PDF »
Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium.
M. Ao, O. E. Franco, D. Park, D. Raman, K. Williams, and S. W. Hayward (2007)
Cancer Res.
67, 4244-4253
|Abstract »|Full Text »|PDF »
Role of Heat Shock Protein 47, a Collagen-Binding Chaperone, in Lacrimal Gland Pathology in Patients with cGVHD.
Y. Ogawa, M. S. Razzaque, K. Kameyama, G. Hasegawa, S. Shimmura, M. Kawai, S. Okamoto, Y. Ikeda, K. Tsubota, Y. Kawakami, et al. (2007)
Invest. Ophthalmol. Vis. Sci.
48, 1079-1086
|Abstract »|Full Text »|PDF »
Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis.
H. G. R. Thompson, J. D. Mih, T. B. Krasieva, B. J. Tromberg, and S. C. George (2006)
Am J Physiol Lung Cell Mol Physiol
291, L1277-L1285
|Abstract »|Full Text »|PDF »
Tgf{beta} signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development.
K. Jiao, M. Langworthy, L. Batts, C. B. Brown, H. L. Moses, and H. S. Baldwin (2006)
Development
133, 4585-4593
|Abstract »|Full Text »|PDF »
Transforming Growth Factor {beta} Receptor Type II Inactivation Induces the Malignant Transformation of Intestinal Neoplasms Initiated by Apc Mutation..
N. M. Munoz, M. Upton, A. Rojas, M. K. Washington, L. Lin, A. Chytil, E. G. Sozmen, B. B. Madison, A. Pozzi, R. T. Moon, et al. (2006)
Cancer Res.
66, 9837-9844
|Abstract »|Full Text »|PDF »
Transforming Growth Factor-{beta} Promotes Invasion in Tumorigenic but not in Nontumorigenic Human Prostatic Epithelial Cells.
M. Ao, K. Williams, N. A. Bhowmick, and S. W. Hayward (2006)
Cancer Res.
66, 8007-8016
|Abstract »|Full Text »|PDF »
Integrin-Mediated Transforming Growth Factor-{beta} Activation Regulates Homeostasis of the Pulmonary Epithelial-Mesenchymal Trophic Unit.
J. Araya, S. Cambier, A. Morris, W. Finkbeiner, and S. L. Nishimura (2006)
Am. J. Pathol.
169, 405-415
|Abstract »|Full Text »|PDF »
Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse..
Y. Teng, A.-N. Sun, X.-C. Pan, G. Yang, L.-L. Yang, M.-R. Wang, and X. Yang (2006)
Cancer Res.
66, 6972-6981
|Abstract »|Full Text »|PDF »
Inhibition of Transforming Growth Factor-{beta} Signaling in Human Cancer: Targeting a Tumor Suppressor Network as a Therapeutic Strategy..
S. Biswas, T. L. Criswell, S. E. Wang, and C. L. Arteaga (2006)
Clin. Cancer Res.
12, 4142-4146
|Full Text »|PDF »
Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-{beta} Type I Receptor Kinase In vivo..
R. Ge, V. Rajeev, P. Ray, E. Lattime, S. Rittling, S. Medicherla, A. Protter, A. Murphy, J. Chakravarty, S. Dugar, et al. (2006)
Clin. Cancer Res.
12, 4315-4330
|Abstract »|Full Text »|PDF »
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.
J.-H. Mao, E. F. Saunier, J. P. de Koning, M. M. McKinnon, M. N. Higgins, K. Nicklas, H.-T. Yang, A. Balmain, and R. J. Akhurst (2006)
PNAS
103, 8125-8130
|Abstract »|Full Text »|PDF »
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
A. Y. Khakoo, S. Pati, S. A. Anderson, W. Reid, M. F. Elshal, I. I. Rovira, A. T. Nguyen, D. Malide, C. A. Combs, G. Hall, et al. (2006)
J. Exp. Med.
203, 1235-1247
|Abstract »|Full Text »|PDF »
hTERT-Immortalized Prostate Epithelial and Stromal-Derived Cells: an Authentic In vitro Model for Differentiation and Carcinogenesis..
I. Kogan, N. Goldfinger, M. Milyavsky, M. Cohen, I. Shats, G. Dobler, H. Klocker, B. Wasylyk, M. Voller, T. Aalders, et al. (2006)
Cancer Res.
66, 3531-3540
|Abstract »|Full Text »|PDF »
Possible Regulation of Migration of Intrahepatic Cholangiocarcinoma Cells by Interaction of CXCR4 Expressed in Carcinoma Cells with Tumor Necrosis Factor-{alpha} and Stromal-Derived Factor-1 Released in Stroma.
S. Ohira, M. Sasaki, K. Harada, Y. Sato, Y. Zen, K. Isse, K. Kozaka, A. Ishikawa, K. Oda, Y. Nimura, et al. (2006)
Am. J. Pathol.
168, 1155-1168
|Abstract »|Full Text »|PDF »
Stromal and epithelial TGF-beta signaling in cancer..
H. L. Moses (2006)
AACR Meeting Abstracts
2006, 1362
|Abstract »
Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production.
M. Ormestad, J. Astorga, H. Landgren, T. Wang, B. R. Johansson, N. Miura, and P. Carlsson (2006)
Development
133, 833-843
|Abstract »|Full Text »|PDF »
The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms.
C. Bavik, I. Coleman, J. P. Dean, B. Knudsen, S. Plymate, and P. S. Nelson (2006)
Cancer Res.
66, 794-802
|Abstract »|Full Text »|PDF »
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies.
Long-Term Cultures of Polarized Airway Epithelial Cells from Patients with Cystic Fibrosis.
L. Wiszniewski, L. Jornot, T. Dudez, A. Pagano, T. Rochat, J. S. Lacroix, S. Suter, and M. Chanson (2006)
Am. J. Respir. Cell Mol. Biol.
34, 39-48
|Abstract »|Full Text »|PDF »
Context-Dependent Hormone-Refractory Progression Revealed through Characterization of a Novel Murine Prostate Cancer Cell Line.
P. A. Watson, K. Ellwood-Yen, J. C. King, J. Wongvipat, M. M. LeBeau, and C. L. Sawyers (2005)
Cancer Res.
65, 11565-11571
|Abstract »|Full Text »|PDF »
Effect of Smad7 Expression on Metastasis of Mouse Mammary Carcinoma JygMC(A) Cells.
H. Azuma, S. Ehata, H. Miyazaki, T. Watabe, O. Maruyama, T. Imamura, T. Sakamoto, S. Kiyama, Y. Kiyama, T. Ubai, et al. (2005)
J Natl Cancer Inst
97, 1734-1746
|Abstract »|Full Text »|PDF »
Mouse models of transforming growth factor {beta} impact in breast development and cancer.
Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer.
M. S. Joesting, S. Perrin, B. Elenbaas, S. E. Fawell, J. S. Rubin, O. E. Franco, S. W. Hayward, G. R. Cunha, and P. C. Marker (2005)
Cancer Res.
65, 10423-10430
|Abstract »|Full Text »|PDF »
Transforming Growth Factor-{beta} Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2.
M. C. Wilkes, H. Mitchell, S. G. Penheiter, J. J. Dore, K. Suzuki, M. Edens, D. K. Sharma, R. E. Pagano, and E. B. Leof (2005)
Cancer Res.
65, 10431-10440
|Abstract »|Full Text »|PDF »
Expression Signature of the Mouse Prostate.
I. M. Berquin, Y. Min, R. Wu, H. Wu, and Y. Q. Chen (2005)
J. Biol. Chem.
280, 36442-36451
|Abstract »|Full Text »|PDF »
Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress.
E Sivridis, A Giatromanolaki, and M I Koukourakis (2005)
J. Clin. Pathol.
58, 1033-1038
|Abstract »|Full Text »|PDF »
Angiotensin II Type 2 Receptor Gene Deficiency Attenuates Susceptibility to Tobacco-Specific Nitrosamine-Induced Lung Tumorigenesis: Involvement of Transforming Growth Factor-{beta}-Dependent Cell Growth Attenuation.
T. Kanehira, T. Tani, T. Takagi, Y. Nakano, E. F. Howard, and M. Tamura (2005)
Cancer Res.
65, 7660-7665
|Abstract »|Full Text »|PDF »
Tumour necrosis factor {alpha} confers an invasive, transformed phenotype on mammary epithelial cells.
R. Montesano, P. Soulie, J. A. Eble, and F. Carrozzino (2005)
J. Cell Sci.
118, 3487-3500
|Abstract »|Full Text »|PDF »
Regulation of Hepatocyte Activator Inhibitor-1 Expression by Androgen and Oncogenic Transformation in the Prostate.
B. S. Knudsen, J. M. Lucas, L. Fazli, S. Hawley, S. Falcon, I. M. Coleman, D. B. Martin, C. Xu, L. D. True, M. E. Gleave, et al. (2005)
Am. J. Pathol.
167, 255-266
|Abstract »|Full Text »|PDF »
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-{alpha} and TGF-{beta}.
C. H. Stuelten, S. D. Byfield, P. R. Arany, T. S. Karpova, W. G. Stetler-Stevenson, and A. B. Roberts (2005)
J. Cell Sci.
118, 2143-2153
|Abstract »|Full Text »|PDF »
Will cancer stem cells provide new therapeutic targets?.
Novel Function of Androgen Receptor-associated Protein 55/Hic-5 as a Negative Regulator of Smad3 Signaling.
H. Wang, K. Song, T. L. Sponseller, and D. Danielpour (2005)
J. Biol. Chem.
280, 5154-5162
|Abstract »|Full Text »|PDF »
Epithelial hedgehog signals pattern the intestinal crypt-villus axis.
B. B. Madison, K. Braunstein, E. Kuizon, K. Portman, X. T. Qiao, and D. L. Gumucio (2005)
Development
132, 279-289
|Abstract »|Full Text »|PDF »
Prostate Stem Cells and Prostate Cancer.
D.A. LAWSON, L. XIN, R. LUKACS, Q. XU, D. CHENG, and O.N. WITTE (2005)
Cold Spring Harb Symp Quant Biol
70, 187-196
|Abstract »|PDF »
Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes.
M.J. BISSELL, P.A. KENNY, and D.C. RADISKY (2005)
Cold Spring Harb Symp Quant Biol
70, 343-356
|Abstract »|PDF »
The Fibroblastic Coconspirator in Cancer Progression.
M. EGEBLAD, L.E. LITTLEPAGE, and Z. WERB (2005)
Cold Spring Harb Symp Quant Biol
70, 383-388
|Abstract »|PDF »
Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets.
K. Fukino, L. Shen, S. Matsumoto, C. D. Morrison, G. L. Mutter, and C. Eng (2004)
Cancer Res.
64, 7231-7236
|Abstract »|Full Text »|PDF »
Gene Expression Profiling of Tumor-Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts.
Differential Effects of Transforming Growth Factor-{beta}1 on Cellular Proliferation in the Developing Prostate.
D. C. Tomlinson, S. H. Freestone, O. C. Grace, and A. A. Thomson (2004)
Endocrinology
145, 4292-4300
|Abstract »|Full Text »|PDF »
Loss of metal transcription factor-1 suppresses tumor growth through enhanced matrix deposition.
Z. A. HAROON, K. AMIN, P. LICHTLEN, B. SATO, N. T. HUYNH, Z. WANG, W. SCHAFFNER, and B. J. MURPHY (2004)
FASEB J
18, 1176-1184
|Abstract »|Full Text »|PDF »
Differential Trafficking of Transforming Growth Factor-{beta} Receptors and Ligand in Polarized Epithelial Cells.
S. J. Murphy, J. J. E. Dore, M. Edens, R. J. Coffey, J. A. Barnard, H. Mitchell, M. Wilkes, and E. B. Leof (2004)
Mol. Biol. Cell
15, 2853-2862
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