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Originally published in Science Express on 15 January 2004
Science 30 January 2004:
Vol. 303. no. 5658, pp. 682 - 684
DOI: 10.1126/science.1092463
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Reports

EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle

Jy-Young Park, You-Qiang Su, Miyako Ariga, Evelyn Law, S.-L. Catherine Jin, Marco Conti*

Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.

Division of Reproductive Biology and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.

* To whom correspondence should be addressed. E-mail: marco.conti{at}stanford.edu

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Mol. Endocrinol. 19, 2591-2602
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Cyclic Adenosine 3',5'-Monophosphate-Dependent Activation of Mitogen-Activated Protein Kinase in Cumulus Cells Is Essential for Germinal Vesicle Breakdown of Porcine Cumulus-Enclosed Oocytes.
C.-G. Liang, L.-J. Huo, Z.-S. Zhong, D.-Y. Chen, H. Schatten, and Q.-Y. Sun (2005)
Endocrinology 146, 4437-4444
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The Art and Artifact of GDF9 Activity: Cumulus Expansion and the Cumulus Expansion-Enabling Factor.
S. A. Pangas and M. M. Matzuk (2005)
Biol Reprod 73, 582-585
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Multiple Signaling Defects in the Absence of RIP140 Impair Both Cumulus Expansion and Follicle Rupture.
J. M. A. Tullet, V. Pocock, J. H. Steel, R. White, S. Milligan, and M. G. Parker (2005)
Endocrinology 146, 4127-4137
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Impact of various endocrine and paracrine factors on in vitro culture of preantral follicles in rodents.
I Demeestere, J Centner, C Gervy, Y Englert, and A Delbaere (2005)
Reproduction 130, 147-156
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Effects of long-term in vitro exposure to phosphodiesterase type-3 inhibitors on follicle and oocyte development.
D Nogueira, R Cortvrindt, B Everaerdt, and J Smitz (2005)
Reproduction 130, 177-186
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Estrogen Receptor-{beta} Is Critical to Granulosa Cell Differentiation and the Ovulatory Response to Gonadotropins.
J. F. Couse, M. M. Yates, B. J. Deroo, and K. S. Korach (2005)
Endocrinology 146, 3247-3262
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Expression and regulation of Sprouty-2 in the granulosa-lutein cells of the corpus luteum.
R. Haimov-Kochman, A. Ravhon, D. Prus, C. Greenfield, Z. Finci-Yeheskel, D. S.Goldman-Wohl, S. Natanson-Yaron, R. Reich, S. Yagel, and A. Hurwitz (2005)
Mol. Hum. Reprod. 11, 537-542
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Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women.
R. T Chatterton Jr, E. T Mateo, N. Hou, A. W Rademaker, S. Acharya, V C. Jordan, and M. Morrow (2005)
J. Endocrinol. 186, 77-84
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Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos.
K. Kawamura, N. Kawamura, S. M. Mulders, M. D. Sollewijn Gelpke, and A. J. W. Hsueh (2005)
PNAS 102, 9206-9211
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Premature ovarian aging in mice deficient for Gpr3.
C. Ledent, I. Demeestere, D. Blum, J. Petermans, T. Hamalainen, G. Smits, and G. Vassart (2005)
PNAS 102, 8922-8926
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Role of Oocyte-Secreted Growth Differentiation Factor 9 in the Regulation of Mouse Cumulus Expansion.
R. A. Dragovic, L. J. Ritter, S. J. Schulz, F. Amato, D. T. Armstrong, and R. B. Gilchrist (2005)
Endocrinology 146, 2798-2806
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Mitogen-Activated Protein Kinase Mediates Luteinizing Hormone-Induced Breakdown of Communication and Oocyte Maturation in Rat Ovarian Follicles.
S. Sela-Abramovich, E. Chorev, D. Galiani, and N. Dekel (2005)
Endocrinology 146, 1236-1244
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