Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Originally published in Science Express on 11 December 2003
Science 16 January 2004:
Vol. 303. no. 5656, pp. 359 - 363
DOI: 10.1126/science.1092436
Prev | Table of Contents | Next

Reports

Defining the Epithelial Stem Cell Niche in Skin

Tudorita Tumbar, Geraldine Guasch, Valentina Greco, Cedric Blanpain, William E. Lowry, Michael Rendl, Elaine Fuchs*

Many adult regenerative cells divide infrequently but have high proliferative capacity. We developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion. We used this method to purify the label-retaining cells (LRCs) that mark the skin stem cell (SC) niche. We found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit. We determined their transcriptional profile, which, when compared to progeny and other SCs, defines the niche. Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment.

Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA.

* To whom correspondence should be addressed. E-mail: fuchslb{at}rockefeller.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4+ T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia.
M. M. A. Rahim, P. Chrobak, C. Hu, Z. Hanna, and P. Jolicoeur (2009)
J. Virol. 83, 11830-11846
   Abstract »    Full Text »    PDF »
Proliferation and Migration of Label-Retaining Cells of the Kidney Papilla.
J. A. Oliver, A. Klinakis, F. H. Cheema, J. Friedlander, R. V. Sampogna, T. P. Martens, C. Liu, A. Efstratiadis, and Q. Al-Awqati (2009)
J. Am. Soc. Nephrol. 20, 2315-2327
   Abstract »    Full Text »    PDF »
A review of tissue-engineered skin bioconstructs available for skin reconstruction.
R. V. Shevchenko, S. L. James, and S. E. James (2009)
J R Soc Interface
   Abstract »    Full Text »    PDF »
Necl2 regulates epidermal adhesion and wound repair.
A. Giangreco, K. B. Jensen, Y. Takai, J. Miyoshi, and F. M. Watt (2009)
Development 136, 3505-3514
   Abstract »    Full Text »    PDF »
Basal cells as stem cells of the mouse trachea and human airway epithelium.
J. R. Rock, M. W. Onaitis, E. L. Rawlins, Y. Lu, C. P. Clark, Y. Xue, S. H. Randell, and B. L. M. Hogan (2009)
PNAS 106, 12771-12775
   Abstract »    Full Text »    PDF »
Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells.
N. Golestaneh, E. Beauchamp, S. Fallen, M. Kokkinaki, A. Uren, and M. Dym (2009)
Reproduction 138, 151-162
   Abstract »    Full Text »    PDF »
Change in gene expression of mouse embryonic stem cells derived from parthenogenetic activation.
S. P. Gong, H. Kim, E. J. Lee, S. T. Lee, S. Moon, H.-J. Lee, and J. M. Lim (2009)
Hum. Reprod. 24, 805-814
   Abstract »    Full Text »    PDF »
The Molecular Regulation of Muscle Stem Cell Function.
M.A. Rudnicki, F. Le Grand, I. McKinnell, and S. Kuang (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin.
A. Haegebarth and H. Clevers (2009)
Am. J. Pathol. 174, 715-721
   Abstract »    Full Text »    PDF »
Bone Marrow-Derived Cells Are Not the Origin of the Cancer Stem Cells in Ultraviolet-Induced Skin Cancer.
S. Ando, R. Abe, M. Sasaki, J. Murata, D. Inokuma, and H. Shimizu (2009)
Am. J. Pathol. 174, 595-601
   Abstract »    Full Text »    PDF »
Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells.
L. Yang, L. Wang, and X. Yang (2009)
Mol. Biol. Cell 20, 882-890
   Abstract »    Full Text »    PDF »
Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma.
M. A. Harris, H. Yang, B. E. Low, J. Mukherje, A. Guha, R. T. Bronson, L. D. Shultz, M. A. Israel, and K. Yun (2008)
Cancer Res. 68, 10051-10059
   Abstract »    Full Text »    PDF »
Stem Cells, Their Niches and the Systemic Environment: An Aging Network.
D. Drummond-Barbosa (2008)
Genetics 180, 1787-1797
   Abstract »    Full Text »    PDF »
Stem Cell Biology in the Lung and Lung Cancers: Employing Pulmonary Context and Classic Approaches.
D.M. Raiser, S.J. Zacharek, R.R. Roach, S.J. Curtis, K.W. Sinkevicius, D.W. Gludish, and C.F. Kim (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Very Long-term Self-renewal of Small Intestine, Colon, and Hair Follicles from Cycling Lgr5+ve Stem Cells.
N. Barker, J.H. van Es, V. Jaks, M. Kasper, H. Snippert, R. Toftgard, and H. Clevers (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Building Epithelial Tissues from Skin Stem Cells.
E. Fuchs and J.A. Nowak (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
White Fat Progenitor Cells Reside in the Adipose Vasculature.
W. Tang, D. Zeve, J. M. Suh, D. Bosnakovski, M. Kyba, R. E. Hammer, M. D. Tallquist, and J. M. Graff (2008)
Science 322, 583-586
   Abstract »    Full Text »    PDF »
Hedgehog Signaling, Keratin 6 Induction, and Sebaceous Gland Morphogenesis: Implications for Pachyonychia Congenita and Related Conditions.
L.-H. Gu and P. A. Coulombe (2008)
Am. J. Pathol. 173, 752-761
   Abstract »    Full Text »    PDF »
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics.
P. P. Szotek, H. L. Chang, K. Brennand, A. Fujino, R. Pieretti-Vanmarcke, C. Lo Celso, D. Dombkowski, F. Preffer, K. S. Cohen, J. Teixeira, et al. (2008)
PNAS 105, 12469-12473
   Abstract »    Full Text »    PDF »
The intestinal stem cell.
N. Barker, M. van de Wetering, and H. Clevers (2008)
Genes & Dev. 22, 1856-1864
   Abstract »    Full Text »    PDF »
One more reason to save your hair.
D. Scholz and S. Ergun (2008)
Cardiovasc Res 79, 1-2
   Full Text »    PDF »
Contractile smooth muscle cells derived from hair-follicle stem cells.
J. Y. Liu, H. F. Peng, and S. T. Andreadis (2008)
Cardiovasc Res 79, 24-33
   Abstract »    Full Text »    PDF »
Melanoma Stem Cells: The Dark Seed of Melanoma.
S. E. Zabierowski and M. Herlyn (2008)
J. Clin. Oncol. 26, 2890-2894
   Abstract »    Full Text »    PDF »
Label-retaining cells of the bladder: candidate urothelial stem cells.
E. A. Kurzrock, D. K. Lieu, L. A. deGraffenried, C. W. Chan, and R. R. Isseroff (2008)
Am J Physiol Renal Physiol 294, F1415-F1421
   Abstract »    Full Text »    PDF »
Limbal Epithelial Crypt: A Model for Corneal Epithelial Maintenance and Novel Limbal Regional Variations.
A. M.-H. Yeung, U. Schlotzer-Schrehardt, B. Kulkarni, N. L. Tint, A. Hopkinson, and H. S. Dua (2008)
Arch Ophthalmol 126, 665-669
   Abstract »    Full Text »    PDF »
Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile.
D. Larouche, X. Tong, J. Fradette, P. A. Coulombe, and L. Germain (2008)
FASEB J 22, 1404-1415
   Abstract »    Full Text »    PDF »
Maintenance and Repair of the Bronchiolar Epithelium.
B. R. Stripp and S. D. Reynolds (2008)
Proceedings of the ATS 5, 328-333
   Abstract »    Full Text »    PDF »
Skin and hair: models for exploring organ regeneration.
B. D. Yu, A. Mukhopadhyay, and C. Wong (2008)
Hum. Mol. Genet. 17, R54-R59
   Abstract »    Full Text »    PDF »
More than one way to skin . . ..
E. Fuchs and V. Horsley (2008)
Genes & Dev. 22, 976-985
   Abstract »    Full Text »    PDF »
Stem Cell Niche: Microenvironment and Beyond.
J. Zhang and L. Li (2008)
J. Biol. Chem. 283, 9499-9503
   Full Text »    PDF »
Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation.
K. M. Osorio, S. E. Lee, D. J. McDermitt, S. K. Waghmare, Y. V. Zhang, H. N. Woo, and T. Tumbar (2008)
Development 135, 1059-1068
   Abstract »    Full Text »    PDF »
Activation of Cardiac Progenitor Cells Reverses the Failing Heart Senescent Phenotype and Prolongs Lifespan.
A. Gonzalez, M. Rota, D. Nurzynska, Y. Misao, J. Tillmanns, C. Ojaimi, M. E. Padin-Iruegas, P. Muller, G. Esposito, C. Bearzi, et al. (2008)
Circ. Res. 102, 597-606
   Abstract »    Full Text »    PDF »
The longest telomeres: a general signature of adult stem cell compartments.
I. Flores, A. Canela, E. Vera, A. Tejera, G. Cotsarelis, and M. A. Blasco (2008)
Genes & Dev. 22, 654-667
   Abstract »    Full Text »    PDF »
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-{beta} and IL-6 signaling.
Y. Tang, K. Kitisin, W. Jogunoori, C. Li, C.-X. Deng, S. C. Mueller, H. W. Ressom, A. Rashid, A. R. He, J. S. Mendelson, et al. (2008)
PNAS 105, 2445-2450
   Abstract »    Full Text »    PDF »
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties.
M. Rendl, L. Polak, and E. Fuchs (2008)
Genes & Dev. 22, 543-557
   Abstract »    Full Text »    PDF »
Skin stem cells: rising to the surface.
E. Fuchs (2008)
J. Cell Biol. 180, 273-284
   Abstract »    Full Text »    PDF »
Stem cell myths.
T. Magnus, Y. Liu, G. C Parker, and M. S Rao (2008)
Phil Trans R Soc B 363, 9-22
   Abstract »    Full Text »    PDF »
Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells.
P. B Dirks (2008)
Phil Trans R Soc B 363, 139-152
   Abstract »    Full Text »    PDF »
Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential.
K. J.L Fernandes, J. G Toma, and F. D Miller (2008)
Phil Trans R Soc B 363, 185-198
   Abstract »    Full Text »    PDF »
The hematopoietic stem cell and its niche: a comparative view.
J. A. Martinez-Agosto, H. K.A. Mikkola, V. Hartenstein, and U. Banerjee (2007)
Genes & Dev. 21, 3044-3060
   Abstract »    Full Text »    PDF »
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
F. B. Furnari, T. Fenton, R. M. Bachoo, A. Mukasa, J. M. Stommel, A. Stegh, W. C. Hahn, K. L. Ligon, D. N. Louis, C. Brennan, et al. (2007)
Genes & Dev. 21, 2683-2710
   Abstract »    Full Text »    PDF »
Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells.
C. F. Kim (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1092-L1098
   Abstract »    Full Text »    PDF »
Dual Role of {alpha}6beta4 Integrin in Epidermal Tumor Growth: Tumor-suppressive Versus Tumor-promoting Function.
K. Raymond, M. Kreft, J.-Y. Song, H. Janssen, and A. Sonnenberg (2007)
Mol. Biol. Cell 18, 4210-4221
   Abstract »    Full Text »    PDF »
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.
I. Siegl-Cachedenier, I. Flores, P. Klatt, and M. A. Blasco (2007)
J. Cell Biol. 179, 277-290
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-{beta} Can Suppress Tumorigenesis through Effects on the Putative Cancer Stem or Early Progenitor Cell and Committed Progeny in a Breast Cancer Xenograft Model.
B. Tang, N. Yoo, M. Vu, M. Mamura, J.-S. Nam, A. Ooshima, Z. Du, P.-Y. Desprez, M. R. Anver, A. M. Michalowska, et al. (2007)
Cancer Res. 67, 8643-8652
   Abstract »    Full Text »    PDF »
Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells.
T. Rubinek, V. Chesnokova, I. Wolf, K. Wawrowsky, G. Vlotides, and S. Melmed (2007)
Am J Physiol Cell Physiol 293, C1082-C1092
   Abstract »    Full Text »    PDF »
Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture.
S. Estrach, J. Legg, and F. M. Watt (2007)
J. Cell Sci. 120, 2944-2952
   Abstract »    Full Text »    PDF »
Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging.
H. Liu, M. M Fergusson, R. M. Castilho, J. Liu, L. Cao, J. Chen, D. Malide, I. I. Rovira, D. Schimel, C. J. Kuo, et al. (2007)
Science 317, 803-806
   Abstract »    Full Text »    PDF »
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
G. Wei, S. Ku, G. K. Ma, S. Saito, A. A. Tang, J. Zhang, J.-H. Mao, E. Appella, A. Balmain, and E. J. Huang (2007)
PNAS 104, 13040-13045
   Abstract »    Full Text »    PDF »
C/EBP{delta} regulates cell cycle and self-renewal of human limbal stem cells.
V. Barbaro, A. Testa, E. Di Iorio, F. Mavilio, G. Pellegrini, and M. De Luca (2007)
J. Cell Biol. 177, 1037-1049
   Abstract »    Full Text »    PDF »
Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineages.
L. Crigler, A. Kazhanie, T.-J. Yoon, J. Zakhari, J. Anders, B. Taylor, and V. M. Virador (2007)
FASEB J 21, 2050-2063
   Abstract »    Full Text »    PDF »
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.
K. Kobielak, N. Stokes, J. de la Cruz, L. Polak, and E. Fuchs (2007)
PNAS 104, 10063-10068
   Abstract »    Full Text »    PDF »
Vitamin D receptor is essential for normal keratinocyte stem cell function.
L. Cianferotti, M. Cox, K. Skorija, and M. B. Demay (2007)
PNAS 104, 9428-9433
   Abstract »    Full Text »    PDF »
CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice.
C. S. Trempus, R. J. Morris, M. Ehinger, A. Elmore, C. D. Bortner, M. Ito, G. Cotsarelis, J. G.W. Nijhof, J. Peckham, N. Flagler, et al. (2007)
Cancer Res. 67, 4173-4181
   Abstract »    Full Text »    PDF »
Epidermal stem cells arise from the hair follicle after wounding.
V. Levy, C. Lindon, Y. Zheng, B. D. Harfe, and B. A. Morgan (2007)
FASEB J 21, 1358-1366
   Abstract »    Full Text »    PDF »
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.
M. Tscharntke, R. Pofahl, A. Chrostek-Grashoff, N. Smyth, C. Niessen, C. Niemann, B. Hartwig, V. Herzog, H. W. Klein, T. Krieg, et al. (2007)
J. Cell Sci. 120, 1480-1490
   Abstract »    Full Text »    PDF »
Evidence for a stem cell hierarchy in the adult human breast.
R. Villadsen, A. J. Fridriksdottir, L. Ronnov-Jessen, T. Gudjonsson, F. Rank, M. A. LaBarge, M. J. Bissell, and O. W. Petersen (2007)
J. Cell Biol. 177, 87-101
   Abstract »    Full Text »    PDF »
Notch signaling controls germline stem cell niche formation in the Drosophila ovary.
X. Song, G. B. Call, D. Kirilly, and T. Xie (2007)
Development 134, 1071-1080
   Abstract »    Full Text »    PDF »
p63 induces key target genes required for epidermal morphogenesis.
M. I. Koster, D. Dai, B. Marinari, Y. Sano, A. Costanzo, M. Karin, and D. R. Roop (2007)
PNAS 104, 3255-3260
   Abstract »    Full Text »    PDF »
Mice cloned from skin cells.
J. Li, V. Greco, G. Guasch, E. Fuchs, and P. Mombaerts (2007)
PNAS 104, 2738-2743
   Abstract »    Full Text »    PDF »
Kruppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells.
Y. Yang, B. G. Goldstein, H. Nakagawa, and J. P. Katz (2007)
FASEB J 21, 543-550
   Abstract »    Full Text »    PDF »
Transcriptional profiling of epidermal differentiation.
N. Radoja, A. Gazel, T. Banno, S. Yano, and M. Blumenberg (2007)
Physiol Genomics 27, 65-78
   Abstract »    Full Text »    PDF »
Uterine stem cells: What is the evidence?.
C.E. Gargett (2007)
Hum. Reprod. Update 13, 87-101
   Abstract »    Full Text »    PDF »
Derivation of oocyte-like cells from a clonal pancreatic stem cell line.
S. Danner, J. Kajahn, C. Geismann, E. Klink, and C. Kruse (2007)
Mol. Hum. Reprod. 13, 11-20
   Abstract »    Full Text »    PDF »
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.
C. de Guzman Strong, P. W. Wertz, C. Wang, F. Yang, P. S. Meltzer, T. Andl, S. E. Millar, I-C. Ho, S.-Y. Pai, and J. A. Segre (2006)
J. Cell Biol. 175, 661-670
   Abstract »    Full Text »    PDF »
Repression of Nanog Gene Transcription by Tcf3 Limits Embryonic Stem Cell Self-Renewal.
L. Pereira, F. Yi, and B. J. Merrill (2006)
Mol. Cell. Biol. 26, 7479-7491
   Abstract »    Full Text »    PDF »
Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase.
S. Pankow, C. Bamberger, A. Klippel, and S. Werner (2006)
J. Cell Sci. 119, 4033-4046
   Abstract »    Full Text »    PDF »
Global Transcriptome Analysis of Genetically Identified Neurons in the Adult Cortex.
M. J. Rossner, J. Hirrlinger, S. P. Wichert, C. Boehm, D. Newrzella, H. Hiemisch, G. Eisenhardt, C. Stuenkel, O. von Ahsen, and K.-A. Nave (2006)
J. Neurosci. 26, 9956-9966
   Abstract »    Full Text »    PDF »
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.
I. Sur, B. Rozell, V. Jaks, A. Bergstrom, and R. Toftgard (2006)
J. Cell Sci. 119, 3593-3601
   Abstract »    Full Text »    PDF »
Side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells.
R. P. Redvers, A. Li, and P. Kaur (2006)
PNAS 103, 13168-13173
   Abstract »    Full Text »    PDF »
Restricted epithelial proliferation by lacritin via PKC{alpha}-dependent NFAT and mTOR pathways.
J. Wang, N. Wang, J. Xie, S. C. Walton, R. L. McKown, R. W. Raab, P. Ma, S. L. Beck, G. L. Coffman, I. M. Hussaini, et al. (2006)
J. Cell Biol. 174, 689-700
   Abstract »    Full Text »    PDF »
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.
K. B. Jensen and F. M. Watt (2006)
PNAS 103, 11958-11963
   Abstract »    Full Text »    PDF »
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes..
M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. (2006)
Mol. Cell. Biol. 26, 6283-6298
   Abstract »    Full Text »    PDF »
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells.
J. G. W. Nijhof, K. M. Braun, A. Giangreco, C. van Pelt, H. Kawamoto, R. L. Boyd, R. Willemze, L. H. F. Mullenders, F. M. Watt, F. R. de Gruijl, et al. (2006)
Development 133, 3027-3037
   Abstract »    Full Text »    PDF »
Transcriptional Profiling of Enriched Populations of Stem Cells Versus Transient Amplifying Cells: A COMPARISON OF LIMBAL AND CORNEAL EPITHELIAL BASAL CELLS.
M. Zhou, X.-m. Li, and R. M. Lavker (2006)
J. Biol. Chem. 281, 19600-19609
   Abstract »    Full Text »    PDF »
A hierarchy of proliferative cells exists in mouse lens epithelium: implications for lens maintenance..
M. Zhou, J. Leiberman, J. Xu, and R. M. Lavker (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2997-3003
   Abstract »    Full Text »    PDF »
Epithelial stem cells of the lung: privileged few or opportunities for many?.
E. L. Rawlins and B. L. M. Hogan (2006)
Development 133, 2455-2465
   Abstract »    Full Text »    PDF »
The regenerative nidi of the locust midgut as a model to study epithelial cell differentiation from stem cells.
I. Illa-Bochaca and L. M. Montuenga (2006)
J. Exp. Biol. 209, 2215-2223
   Abstract »    Full Text »    PDF »
Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles.
H. Yu, D. Fang, S. M. Kumar, L. Li, T. K. Nguyen, G. Acs, M. Herlyn, and X. Xu (2006)
Am. J. Pathol. 168, 1879-1888
   Abstract »    Full Text »    PDF »
Normal Stem Cells and Cancer Stem Cells: The Niche Matters..
L. Li and W. B. Neaves (2006)
Cancer Res. 66, 4553-4557
   Abstract »    Full Text »    PDF »
Molecular Properties of Adult Mouse Gastric and Intestinal Epithelial Progenitors in Their Niches.
M. Giannakis, T. S. Stappenbeck, J. C. Mills, D. G. Leip, M. Lovett, S. W. Clifton, J. E. Ippolito, J. I. Glasscock, M. Arumugam, M. R. Brent, et al. (2006)
J. Biol. Chem. 281, 11292-11300
   Abstract »    Full Text »    PDF »
Stem cells and their niches..
K. A. Moore and I. R. Lemischka (2006)
Science 311, 1880-1885
   Abstract »    Full Text »    PDF »
Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma.
J. D. Raman, N. P. Mongan, L. Liu, S. K. Tickoo, D. M. Nanus, D. S. Scherr, and L. J. Gudas (2006)
Carcinogenesis 27, 499-507
   Abstract »    Full Text »    PDF »
The hair cycle.
L. Alonso and E. Fuchs (2006)
J. Cell Sci. 119, 391-393
   Full Text »    PDF »
Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity.
N. D. Theise (2006)
Am J Physiol Gastrointest Liver Physiol 290, G189-G193
   Abstract »    Full Text »    PDF »
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1.
A. Gebhardt, M. Frye, S. Herold, S. A. Benitah, K. Braun, B. Samans, F. M. Watt, H.-P. Elsasser, and M. Eilers (2006)
J. Cell Biol. 172, 139-149
   Abstract »    Full Text »    PDF »
Expression of RNA-Binding Protein Musashi in Hair Follicle Development and Hair Cycle Progression.
Y. Sugiyama-Nakagiri, M. Akiyama, S. Shibata, H. Okano, and H. Shimizu (2006)
Am. J. Pathol. 168, 80-92
   Abstract »    Full Text »    PDF »
Molecular characterization of melanocyte stem cells in their niche.
M. Osawa, G. Egawa, S.-S. Mak, M. Moriyama, R. Freter, S. Yonetani, F. Beermann, and S.-I. Nishikawa (2005)
Development 132, 5589-5599
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)