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Originally published in Science Express on 26 November 2003
Science 16 January 2004:
Vol. 303. no. 5656, pp. 343 - 348
DOI: 10.1126/science.1090701
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Research Articles

ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

Gaku Mizuguchi,* Xuetong Shen,*{dagger} Joe Landry,* Wei-Hua Wu,{ddagger} Subhojit Sen,{ddagger} Carl Wu§

The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. These findings define a previously unknown role for the adenosine triphosphate–dependent chromatin remodeling machinery.

Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6068, Bethesda, MD 20892–4255, USA.



Note added in proof: The subunits of the SWR1 complex—Vps72, Swc1, God1, Aor1, and Vps71— have been renamed Swc2, Swc3, Swc4, Swc5, and Swc6, respectively, by agreement with the laboratories of J. Greenblatt, H. Madhani, and J. Rine.

* These authors contributed equally to this work.

{dagger} Present address: Department of Carcinogenesis, MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA.

{ddagger} These authors contributed equally to this work.

§ To whom correspondence should be addressed. E-mail: carlwu{at}helix.nih.gov

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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T. Furman, J. Bryce, T. Rooney, B. Hanan, G. Yirgu, and D. Ayalew (2006)
Geological Society, London, Special Publications 259, 95-119
   Abstract »    PDF »
Changes in Attitude, Changes in Latitude: Nuclear Receptors Remodeling Chromatin to Regulate Transcription.
J. Chen, H. K. Kinyamu, and T. K. Archer (2006)
Mol. Endocrinol. 20, 1-13
   Abstract »    Full Text »    PDF »
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling.
B. Li, S. G. Pattenden, D. Lee, J. Gutierrez, J. Chen, C. Seidel, J. Gerton, and J. L. Workman (2005)
PNAS 102, 18385-18390
   Abstract »    Full Text »    PDF »
The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
D. J. Dilworth, A. J. Tackett, R. S. Rogers, E. C. Yi, R. H. Christmas, J. J. Smith, A. F. Siegel, B. T. Chait, R. W. Wozniak, and J. D. Aitchison (2005)
J. Cell Biol. 171, 955-965
   Abstract »    Full Text »    PDF »
A Mammalian Chromatin Remodeling Complex with Similarities to the Yeast INO80 Complex.
J. Jin, Y. Cai, T. Yao, A. J. Gottschalk, L. Florens, S. K. Swanson, J. L. Gutierrez, M. K. Coleman, J. L. Workman, A. Mushegian, et al. (2005)
J. Biol. Chem. 280, 41207-41212
   Abstract »    Full Text »    PDF »
Dynamic regulation of replication independent deposition of histone H3 in fission yeast.
E. S. Choi, J. A Shin, H. S. Kim, and Y. K. Jang (2005)
Nucleic Acids Res. 33, 7102-7110
   Abstract »    Full Text »    PDF »


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