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A C. elegans CLIC-like Protein Required for Intracellular Tube Formation and Maintenance
Katherine L. Berry,1Hannes E. Bülow,1David H. Hall,2Oliver Hobert1*
The Caenorhabditis elegans excretory canal is composed of asingle elongated and branched cell that is tunneled by an innerlumen of apical character. Loss of the exc-4 gene causes a cysticenlargement of this intracellular tube. exc-4 encodes a memberof the chloride intracellular channel (CLIC) family of proteins.EXC-4 protein localizes to various tubular membranes in distinctcell types, including the lumenal membrane of the excretorytubes. A conserved 55–amino acid domain enables EXC-4translocation from the cytosol to the lumenal membrane. Thetubular architecture of this membrane requires EXC-4 for bothits formation and maintenance.
1 Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA. 2 Department of Neuroscience, Center for C. elegans Anatomy, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
* To whom correspondence should be addressed. E-mail: or38{at}columbia.edu
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