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Originally published in Science Express on 13 November 2003
Science 5 December 2003:
Vol. 302. no. 5651, pp. 1760 - 1765
DOI: 10.1126/science.1088417
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Reports

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Michelle L. Monje, Hiroki Toda, Theo D. Palmer*

Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.

Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305–5487, USA.

* To whom correspondence should be addressed. E-mail: tpalmer{at}stanford.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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A.-M. Samuelsson, E. Jennische, H.-A. Hansson, and A. Holmang (2006)
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   Abstract »    Full Text »    PDF »
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A. Belmadani, P. B. Tran, D. Ren, and R. J. Miller (2006)
J. Neurosci. 26, 3182-3191
   Abstract »    Full Text »    PDF »
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L. Deleyrolle, S. Marchal-Victorion, C. Dromard, V. Fritz, M. Saunier, J.-C. Sabourin, C. Tran Van Ba, A. Privat, and J.-P. Hugnot (2006)
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   Abstract »    Full Text »    PDF »
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P. Thored, A. Arvidsson, E. Cacci, H. Ahlenius, T. Kallur, V. Darsalia, C. T. Ekdahl, Z. Kokaia, and O. Lindvall (2006)
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   Abstract »    Full Text »    PDF »
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A.-L. Siren, K. Radyushkin, S. Boretius, D. Kammer, C.-C. Riechers, O. Natt, D. Sargin, T. Watanabe, S. Sperling, T. Michaelis, et al. (2006)
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   Abstract »    Full Text »    PDF »
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G. L. Hermes, L. Rosenthal, A. Montag, and M. K. McClintock (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R273-R282
   Abstract »    Full Text »    PDF »
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A. Buffo, M. R. Vosko, D. Erturk, G. F. Hamann, M. Jucker, D. Rowitch, and M. Gotz (2005)
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   Abstract »    Full Text »    PDF »
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W. S. Sheng, S. Hu, H. T. Ni, T. N. Rowen, J. R. Lokensgard, and P. K. Peterson (2005)
J. Leukoc. Biol. 78, 1233-1241
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. Aharoni, R. Arnon, and R. Eilam (2005)
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   Abstract »    Full Text »    PDF »
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G. P. Marshall II, E. W. Scott, T. Zheng, E. D. Laywell, and D. A. Steindler (2005)
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   Abstract »    Full Text »    PDF »
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E. K. de Jong, I. M. Dijkstra, M. Hensens, N. Brouwer, M. van Amerongen, R. S. B. Liem, H. W. G. M. Boddeke, and K. Biber (2005)
J. Neurosci. 25, 7548-7557
   Abstract »    Full Text »    PDF »
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M. Kohwi, N. Osumi, J. L. R. Rubenstein, and A. Alvarez-Buylla (2005)
J. Neurosci. 25, 6997-7003
   Abstract »    Full Text »    PDF »
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R.-S. Ge, Q. Dong, C. M. Sottas, H. Chen, B. R. Zirkin, and M. P. Hardy (2005)
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   Abstract »    Full Text »    PDF »
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M. Dateki, T. Horii, Y. Kasuya, R. Mochizuki, Y. Nagao, J. Ishida, F. Sugiyama, K. Tanimoto, K.-i. Yagami, H. Imai, et al. (2005)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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P. M. Wise, D. B. Dubal, S. W. Rau, C. M. Brown, and S. Suzuki (2005)
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   Abstract »    Full Text »    PDF »
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D. N. Abrous, M. Koehl, and M. Le Moal (2005)
Physiol Rev 85, 523-569
   Abstract »    Full Text »    PDF »
Increased Neurogenesis in Dentate Gyrus of Long-Lived Ames Dwarf Mice.
L. Y. Sun, M. S. Evans, J. Hsieh, J. Panici, and A. Bartke (2005)
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   Abstract »    Full Text »    PDF »
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S. W. Suh, Y. Fan, S. M. Hong, Z. Liu, Y. Matsumori, P. R. Weinstein, R. A. Swanson, and J. Liu (2005)
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   Abstract »    Full Text »    PDF »
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J. Imitola, K. Raddassi, K. I. Park, F.-J. Mueller, M. Nieto, Y. D. Teng, D. Frenkel, J. Li, R. L. Sidman, C. A. Walsh, et al. (2004)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. B. Rock, G. Gekker, S. Hu, W. S. Sheng, M. Cheeran, J. R. Lokensgard, and P. K. Peterson (2004)
Clin. Microbiol. Rev. 17, 942-964
   Abstract »    Full Text »    PDF »
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A. F. Schinder and F. H. Gage (2004)
Physiology 19, 253-261
   Abstract »    Full Text »    PDF »
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K. Jin, V. Galvan, L. Xie, X. O. Mao, O. F. Gorostiza, D. E. Bredesen, and D. A. Greenberg (2004)
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   Abstract »    Full Text »    PDF »


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