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Science 5 December 2003:
Vol. 302. no. 5651, pp. 1757 - 1760
DOI: 10.1126/science.1091422
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Reports

The Needle Length of Bacterial Injectisomes Is Determined by a Molecular Ruler

Laure Journet, Céline Agrain, Petr Broz, Guy R. Cornelis*

Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.

Biozentrum, Universität Basel, 4056 Basel, Switzerland.

* To whom correspondence should be addressed: E-mail: guy.cornelis{at}unibas.ch

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