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Science 5 December 2003:
Vol. 302. no. 5651, pp. 1704 - 1709
DOI: 10.1126/science.1092053
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Review

Cell Migration: Integrating Signals from Front to Back

Anne J. Ridley,1 Martin A. Schwartz,2 Keith Burridge,5 Richard A. Firtel,6 Mark H. Ginsberg,7 Gary Borisy,8 J. Thomas Parsons,3 Alan Rick Horwitz4

Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.

1 Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.
2 Departments of Microbiology and Biomedical Engineering, Cardiovascular Research Center and Mellon Prostate Cancer Research Institute; University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
3 Department of Microbiology; University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
4 Department of Cell Biology; University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
5 Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
6 Section of Cell and Developmental Biology, Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0634, USA.
7 Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
8 Department of Cellular and Molecular Biology, Northwestern University, School of Medicine, Chicago, IL 60611, USA.

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Analysis of WASp function during the wound inflammatory response - live-imaging studies in zebrafish larvae.
A. Cvejic, C. Hall, M. Bak-Maier, M. V. Flores, P. Crosier, M. J. Redd, and P. Martin (2008)
J. Cell Sci. 121, 3196-3206
   Abstract »    Full Text »    PDF »
Therapeutic IMC-C225 Antibody Inhibits Breast Cancer Cell Invasiveness via Vav2-Dependent Activation of RhoA GTPase.
P. R. Molli, L. Adam, and R. Kumar (2008)
Clin. Cancer Res. 14, 6161-6170
   Abstract »    Full Text »    PDF »
Nonmuscle myosin II is responsible for maintaining endothelial cell basal tone and stress fiber integrity.
Z. M. Goeckeler, P. C. Bridgman, and R. B. Wysolmerski (2008)
Am J Physiol Cell Physiol 295, C994-C1006
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor-induced Enhancement of Glioblastoma Cell Migration in 3D Arises from an Intrinsic Increase in Speed But an Extrinsic Matrix- and Proteolysis-dependent Increase in Persistence.
H.-D. Kim, T. W. Guo, A. P. Wu, A. Wells, F. B. Gertler, and D. A. Lauffenburger (2008)
Mol. Biol. Cell 19, 4249-4259
   Abstract »    Full Text »    PDF »
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors.
M. Ouyang, J. Sun, S. Chien, and Y. Wang (2008)
PNAS 105, 14353-14358
   Abstract »    Full Text »    PDF »
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors.
S. Antoku, K. Saksela, G. M. Rivera, and B. J. Mayer (2008)
J. Cell Sci. 121, 3071-3082
   Abstract »    Full Text »    PDF »
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
M. A. West, A. R. Prescott, K. M. Chan, Z. Zhou, S. Rose-John, J. Scheller, and C. Watts (2008)
J. Cell Biol. 182, 993-1005
   Abstract »    Full Text »    PDF »
ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65.
B. Bisel, Y. Wang, J.-H. Wei, Y. Xiang, D. Tang, M. Miron-Mendoza, S.-i. Yoshimura, N. Nakamura, and J. Seemann (2008)
J. Cell Biol. 182, 837-843
   Abstract »    Full Text »    PDF »
Sphingosine 1-Phosphate Potentiates Human Lung Fibroblast Chemotaxis through the S1P2 Receptor.
M. Hashimoto, X. Wang, L. Mao, T. Kobayashi, S. Kawasaki, N. Mori, M. L. Toews, H. J. Kim, D. R. Cerutis, X. Liu, et al. (2008)
Am. J. Respir. Cell Mol. Biol. 39, 356-363
   Abstract »    Full Text »    PDF »
Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1.
S. W. Moore, J. P. Correia, K. Lai Wing Sun, M. Pool, A. E. Fournier, and T. E. Kennedy (2008)
Development 135, 2855-2864
   Abstract »    Full Text »    PDF »


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