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Originally published in Science Express on 25 September 2003
Science 14 November 2003:
Vol. 302. no. 5648, pp. 1218 - 1222
DOI: 10.1126/science.1086507
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The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Kyeong-Hee Lee,1,2* Aaron R. Dinner,3*{ddagger} Chun Tu,1 Gabriele Campi,5 Subhadip Raychaudhuri,4 Rajat Varma,5 Tasha N. Sims,5 W. Richard Burack,1 Hui Wu,1 Julia Wang,1 Osami Kanagawa,1 Mary Markiewicz,1 Paul M. Allen,1 Michael L. Dustin,5{dagger} Arup K. Chakraborty,3,4,6{dagger} Andrey S. Shaw1{dagger}

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

1 Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA.
2 Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA.
3 Department of Chemistry, University of California, Berkeley, CA 94720, USA.
4 Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.
5 Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA.
6 Physical Biosciences and Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.



* These authors contributed equally to this work.

{ddagger} Present address: Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.

{dagger} To whom correspondence should be addressed: E-mail: shaw{at}pathbox.wustl.edu (A.S.S.), arup{at}uclink.berkeley.edu (A.K.C.), and dustin{at}saturn.med.nyu.edu (M.L.D.)

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